Title: rhodos vortrag
1Inflammation and nose
2Exposure group Bitumen workers
3Reference group outdoor construction workers
4Characteristics of the study population
High exposure
Low exposure
High exposure
Low exposure
References
Exposed (total)
References
Exposed (total)
gt10 mg/m
?10 mg/m
?10 mg/m
?10 mg/m
3
3
3
3
Attribute
Attribute
n55
n30
n172
n202
n55
n30
n172
n202
Exposure to fumes
Exposure to fumes of
and aerosols of
16.7
(10.2
-
41.7)
3.0 (0.1
-
9.8)
3.7 (0.1
-
41.7)
16.7
(10.2
-
41.7)
3.0 (0.1
-
9.8)
3.7 (0.1
-
41.7)
bitumen (mg/m
3
)
bitumen (mg/m
3
)
?
-
(median range)
(median range)
Age (years)
Age (years)
37 (19
-
61)
40.5 (17
-
52)
40 (18
-
63)
40 (17
-
63)
37 (19
-
61)
40.5 (17
-
52)
40 (18
-
63)
40 (17
-
63)
(median range)
(median range)
Current smoking
Current smoking
23 (
41.8
)
20 (66.7)
113 (65.7)
132 (
65.7
)
23 (
41.8
)
20 (66.7)
113 (65.7)
132 (
65.7
)
n ()
n ()
German nationality
German nationality
48 (
87.3
)
15 (50.0)
121 (70.8)
136 (
67.7
)
48 (
87.3
)
15 (50.0)
121 (70.8)
136 (
67.7
)
n ()
n ()
Duration of work in
Duration of work in
the current
the current
company (years)
company (years)
6.5 (3
-
10)
6.5 (2
-
16)
8 (3
-
14)
8 (3
-
14
)
6.5 (3
-
10)
6.5 (2
-
16)
8 (3
-
14)
8 (3
-
14
)
(median
(median
interquartile range)
interquartile range)
5Collection of nasal lavage fluids (NALF)
Analysis cellular and humoral parameters
(e.g. IL-8, IL-1b, TNF-a, IL-6, NO, albumin)
6Neutrophils in NALF pre-/post-shift-compari
son in the three exposure groups
60
55
50
45
p0.023
p0.010
40
Neutrophils in NALF
35
p0.020
p0.0002
30
25
20
15
pre-shift
post-shift
reference group
low exposure group
high exposure group
7IL-8-determination in NALF
pre-/post-shift-comparison in the three exposure
groups
350
300
250
200
n.s.
IL-8-concentration in NALF pg/ml
150
n.s.
100
50
0
pre-shift
post-shift
reference group
low exposure group
high exposure group
8Conclusion NALF
- Small increase of neutrophils after high airborne
bitumen exposure during shift in nasal lavage - Although no direct comparison was made,
irritative effects can possibly be differentiated
from allergic effects