The price trend for Valsartan API in the North American region followed an increasing path in the second quarter of 2022. Healthy downstream pharmaceutical demand with lessened supply and reduced stocks with the suppliers affected the cost of Valsartan API further. During the second quarter, the market was volatile also due to protracted port congestion and a disrupted supply chain from China. Also, the trading activities were disrupted from various exporting countries resulting in higher freight charges and rerouting activity, positively impacting the price of Valsartan API. Also, manufacturing costs have risen in tandem with rising energy costs because of the recent rise in crude oil prices. Towards the end of the quarter, Valsartan prices were assessed at USD 143000/MT for CFR New York in June 2022.
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Valsartan (Angiotan or Diovan) is an angiotensin II receptor antagonist (more commonly called an ARB, or angiotensin receptor blocker), with particularly high affinity for the type I (AT1) angiotensin receptor. In December 1996, Valsartan was approved by FDA.
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Neprilysin inhibitors hereby cause an increase in natriuretic peptides, which are mainly important for maintaining fluid as well as sodium balance through natriuresis, diuresis, and vasodilation. This lowers blood pressure and effectively treats heart failure. Neprilysin can be used in combination with other medications to improve treatment for heart failure. Therefore, anti-neprilysin drugs are used to treat high blood pressure, heart failure, kidney disease, and others. Sacubitril / Valsartan is used instead of an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) and in conjunction with treatment when it does not work in patients with heart disease. The inhibition of neprilysin helps increase the level of natriuretic peptides. Neprilysin inhibitors help lower the risk of heart failure and lower blood pressure. The COVID-19 pandemic has significantly increased the demand for several dru.
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