Creating RDF Representations of Patient Data

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Creating RDF Representations of Patient Data
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Diabetes Patient Data

• 54-year-old man with diabetes was referred to the
  Hypertension Clinic in Jichi Medical School
  Hospital with symptoms of dizziness and
  orthostatic intolerance. In 2002, he started
  insulin therapy (Hemoglobin A1c 9 ), and in
  2004, he was started on a once daily dose of
  valsartan 80 mg for hypertension. He sometimes
  complained of dizziness and fainting while
  standing. On 13 February 2005, he fell down while
  riding a bicycle. As the clinic BP was 84/60 mm
  Hg on 14 March, and the valsartan was stopped. He
  was referred to otolaryngology and neurology, but
  no significant abnormalities were detected.

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URI
subject? or has_symptom?
age?
Collection of Symptoms
54 years
_2
_1
Dizziness
Orthostatic Intolerance
maps_to
maps_to
Snomed URI2
Snomed URI1
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Design Choices

• What are the nodes of this graph?
• What are the types of the nodes of this graphs
  (RDF(S)/OWL Classes)?
• What are the labels of the edges of this graph?
• How do we decide the classes and instances?
• How do we deal with Industry Standards such as
  RIM/CDA/SDTM/DCM Snomed/NCI Thesaurus etc.?
• Can node types and edge labels be derived from
  these standards?
• Can we have specialized edge (maps_to) to link
  nodes in this graph with Snomed/NCI Thesaurus
  concepts?
• How do we choose these to ensure interoperability
  across multiple standards?
• How do we represent temporal data and
  information?
• How do we capture abstractions such as a clinical
  event, a patient encounter?

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Name Space Issues

• Proposal Create Namespaces for each of the
  standards
• hl7rim HL7/RIM
• dcm Detailed Clinical Models
• cda Clinical Documentation Architecture
• sdtm Study Data Tabulation Model
• snomed Snomed
• ncit NCI Thesaurus

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How do we scope this effort?
Systolic Blood Pressure
Known head injury
Suspected head injury
Pregnancy
Type 2 diabetes
FPG
HbA1c
Women of childbearing potential
Type 1 diabetes
Ketacidosis
History of ltCondition/Diagnosisgt
Severe Diabetic Neuropathy
Autonomic Neuropathy
Gastroporesis
Lower Limb Ulceration
Lower Limb Amputation
Intentional Weight Loss
Period of time for Weight Loss
Serum creatinine
eGFR
Chronic Kidney Disease Stage 3
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Proposed Tasks/Groups

• HL7/RIM Helen, Vipul, Dan
• DCM Tom Oniki, Stan Huff
• Realist Approach Kerstin, Bo, Alan
• SDTM Rachel, Jennifer
• POMR Vipul

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Examples of Eligibility Criteria
Example Patient Data
Various Standards HL7, CDISC, etc.
RDF/OWL Graphs