Dihydrofolate PowerPoint PPT Presentations

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Dihydrofolate Reductase as a Paradigm of Rational Drug Design PowerPoint PPT Presentation
Dihydrofolate Reductase as a Paradigm of Rational Drug Design - Dihydrofolate Reductase as a Paradigm of Rational Drug Design ... the steric effect and greater the density, the smaller the steric effect (the ...
Dihydrofolate Reductase as a Paradigm of Rational Drug Design ... the steric effect and greater the density, the smaller the steric effect (the ...
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Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Design and High-Throughput Synthesis and Screening PowerPoint PPT Presentation
Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Design and High-Throughput Synthesis and Screening - ... nosocomial infections, pneumonia ... Goal and methods Design novel DHFR ... Diversity-based library design Known potent compounds had high molecular ...
... nosocomial infections, pneumonia ... Goal and methods Design novel DHFR ... Diversity-based library design Known potent compounds had high molecular ...
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Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Design and High-Throughput Synthesis and Screening PowerPoint PPT Presentation
Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Design and High-Throughput Synthesis and Screening - Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Design and High-Throughput Synthesis and Screening Pierre C. Wyss, Paul Gerber, Peter ...
Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Design and High-Throughput Synthesis and Screening Pierre C. Wyss, Paul Gerber, Peter ...
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Synthesis, Molecular Modeling, and Dihydrofolate Reductase Inhibition Activity of Some New 43Hquinaz PowerPoint PPT Presentation
Synthesis, Molecular Modeling, and Dihydrofolate Reductase Inhibition Activity of Some New 43Hquinaz - DHFR functions as a catalyst for the reduction of dihydrofolate to tetrahydrofolate. ... Bovine liver DHFR was used for the assay. It is 70% homologous to hDHFR. ...
DHFR functions as a catalyst for the reduction of dihydrofolate to tetrahydrofolate. ... Bovine liver DHFR was used for the assay. It is 70% homologous to hDHFR. ...
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?????????Alimta????? PowerPoint PPT Presentation
?????????Alimta????? - ... Dihydrofolate reductase ...
... Dihydrofolate reductase ...
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Enseignements Dirig PowerPoint PPT Presentation
Enseignements Dirig - ... Cas clinique n 2 M thotrexate ( Novatrex) : Inhibiteur de la dihydrofolate r ductase, effet immunomodulateur puissant Utilis faible dose ...
... Cas clinique n 2 M thotrexate ( Novatrex) : Inhibiteur de la dihydrofolate r ductase, effet immunomodulateur puissant Utilis faible dose ...
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Protein Purification: From industrial enzymes to cancer therapy PowerPoint PPT Presentation
Protein Purification: From industrial enzymes to cancer therapy - ... protein expression and purification for biomanufacturing Dihydrofolate reductase Affinity purification Perform affinity chromatography Perform size exclusion ...
... protein expression and purification for biomanufacturing Dihydrofolate reductase Affinity purification Perform affinity chromatography Perform size exclusion ...
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Biosynthesis of Nucleotides and Nucleic Acids PowerPoint PPT Presentation
Biosynthesis of Nucleotides and Nucleic Acids - cells have a requirement for the synthesis of new DNA. ... Thymidylate synthase and dihydrofolate reductase, enzymes critical for ...
cells have a requirement for the synthesis of new DNA. ... Thymidylate synthase and dihydrofolate reductase, enzymes critical for ...
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ReadingChapter 14 PowerPoint PPT Presentation
ReadingChapter 14 - HMG-CoA reductase inhibitor. Lowers LDL cholesterol. Celecoxib (Celebrex) COX-2 inhibitor ... Inhibits dihydrofolate reductase. Anticancer agent (leukemia) ...
HMG-CoA reductase inhibitor. Lowers LDL cholesterol. Celecoxib (Celebrex) COX-2 inhibitor ... Inhibits dihydrofolate reductase. Anticancer agent (leukemia) ...
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Regulation of gene expression PowerPoint PPT Presentation
Regulation of gene expression - Mechanisms by which expression of genes is regulated in prokaryotes and eukaryotes
Mechanisms by which expression of genes is regulated in prokaryotes and eukaryotes
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One Carbon Pool By Folate PowerPoint PPT Presentation
One Carbon Pool By Folate - Folic Acid. HMDB00121. ONE CARBON POOL BY FOLATE. In Homo sapiens ... 5,10- methenyl THF. HMDB01354. Phosphoribosylglycinamide. formyltransferase. A8KA32 ...
Folic Acid. HMDB00121. ONE CARBON POOL BY FOLATE. In Homo sapiens ... 5,10- methenyl THF. HMDB01354. Phosphoribosylglycinamide. formyltransferase. A8KA32 ...
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Enzyme Inhibition PowerPoint PPT Presentation
Enzyme Inhibition - Enzymology
Enzymology
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26' Deoxyribonucleotide biosynthesis and nucleotide catabolism drug design and testing PowerPoint PPT Presentation
26' Deoxyribonucleotide biosynthesis and nucleotide catabolism drug design and testing - 26. Deoxyribonucleotide biosynthesis and nucleotide catabolism; drug design and testing ... Enzymes of nucleotide biosynthesis provide targets for cancer ...
26. Deoxyribonucleotide biosynthesis and nucleotide catabolism; drug design and testing ... Enzymes of nucleotide biosynthesis provide targets for cancer ...
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The%20Practical%20Side%20of%20Nucleotide%20Metabolism PowerPoint PPT Presentation
The%20Practical%20Side%20of%20Nucleotide%20Metabolism - Finish up Tuesday's Leftovers. Brief Explanation of how dUMP is converted to dTMP. Some clinically relevant treatments based on these pathways that are used to combat: ...
Finish up Tuesday's Leftovers. Brief Explanation of how dUMP is converted to dTMP. Some clinically relevant treatments based on these pathways that are used to combat: ...
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SULFONAMIDES PowerPoint PPT Presentation
SULFONAMIDES - ADVERSE EFFECTS Hypersensitivity reactions -common allergic rashes ... (sulfadoxine) THERAPEUTIC USES Parasitic diseases (combined with other antimicrobials ...
ADVERSE EFFECTS Hypersensitivity reactions -common allergic rashes ... (sulfadoxine) THERAPEUTIC USES Parasitic diseases (combined with other antimicrobials ...
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b-???? PowerPoint PPT Presentation
b-???? - Title: PowerPoint Author: VAIO Last modified by: pharm Created Date: 10/3/2003 1:43:49 AM Document presentation format:
Title: PowerPoint Author: VAIO Last modified by: pharm Created Date: 10/3/2003 1:43:49 AM Document presentation format:
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Enzymes%20as%20diagnostic%20 PowerPoint PPT Presentation
Enzymes%20as%20diagnostic%20 - (Use in alzheimer disease, glaucoma) ... Statins inhibit this enzyme, ... Clinical Enzymology Author: Haiza Last modified by:
(Use in alzheimer disease, glaucoma) ... Statins inhibit this enzyme, ... Clinical Enzymology Author: Haiza Last modified by:
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21' Deoxyribonucleotide biosynthesis and nucleotide catabolism PowerPoint PPT Presentation
21' Deoxyribonucleotide biosynthesis and nucleotide catabolism - Thymidylate synthase oxidizes N5,N10-methylenetetrahydrofolate to ... Fish and most terrestrial mammals oxidize uric acid further before excreting the ...
Thymidylate synthase oxidizes N5,N10-methylenetetrahydrofolate to ... Fish and most terrestrial mammals oxidize uric acid further before excreting the ...
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Molecular%20Methods%20of%20cell%20culture%20I PowerPoint PPT Presentation
Molecular%20Methods%20of%20cell%20culture%20I - Title: Author: CS907 Last modified by: Jamie Created Date: 11/24/1999 2:01:16 AM Document presentation format: (4:3)
Title: Author: CS907 Last modified by: Jamie Created Date: 11/24/1999 2:01:16 AM Document presentation format: (4:3)
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Purine PowerPoint PPT Presentation
Purine - Asparate Ribose 5-phosphate PRPP Phosphoribosyl amine IMP ... Nucleotidases Nucleoside phosphorylases Deaminases Xanthine oxidases 3. the final common ...
Asparate Ribose 5-phosphate PRPP Phosphoribosyl amine IMP ... Nucleotidases Nucleoside phosphorylases Deaminases Xanthine oxidases 3. the final common ...
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Michaelis-Menten kinetics PowerPoint PPT Presentation
Michaelis-Menten kinetics - is low (close to zero time) Michaelis-Menten Equation. E S ES E P. Michaelis-Menten Model ... [P] is low (close to zero. time), hence, V0 for. initial ...
is low (close to zero time) Michaelis-Menten Equation. E S ES E P. Michaelis-Menten Model ... [P] is low (close to zero. time), hence, V0 for. initial ...
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MECHANISMS OF ACTION OF ANTIBIOTICS PowerPoint PPT Presentation
MECHANISMS OF ACTION OF ANTIBIOTICS - MECHANISMS OF ACTION OF ANTIBIOTICS BACTERIOSTATIC AGENTS Sulfonamides Drugs inhibiting protein synthesis except aminoglycosides (macrolides, chloramphenicol ...
MECHANISMS OF ACTION OF ANTIBIOTICS BACTERIOSTATIC AGENTS Sulfonamides Drugs inhibiting protein synthesis except aminoglycosides (macrolides, chloramphenicol ...
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Niacin Vitamin B3 PowerPoint PPT Presentation
Niacin Vitamin B3 - 0. 4-Methyl-5-hydroxyethyl-thiazole. Methylene bridge. THIAMIN (VITAMIN B1) ... synthesis ??? catabolism ??? amino acids. ??? enzyme glycogen phosphorylase ?? ...
0. 4-Methyl-5-hydroxyethyl-thiazole. Methylene bridge. THIAMIN (VITAMIN B1) ... synthesis ??? catabolism ??? amino acids. ??? enzyme glycogen phosphorylase ?? ...
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Antifolates, DNA gyrase inhibitors, Novel lipopeptides PowerPoint PPT Presentation
Antifolates, DNA gyrase inhibitors, Novel lipopeptides - Title: Sulfonamides,Trimethoprim and Quinolones Last modified by: Sushike Created Date: 5/26/2003 11:39:43 PM Document presentation format ...
Title: Sulfonamides,Trimethoprim and Quinolones Last modified by: Sushike Created Date: 5/26/2003 11:39:43 PM Document presentation format ...
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Anti-parasitic%20Agents PowerPoint PPT Presentation
Anti-parasitic%20Agents - Used to treat intestinal helminth infections, especially those caused by nematodes and cestodes ... used in China for over 200 years to treat fever and chills ...
Used to treat intestinal helminth infections, especially those caused by nematodes and cestodes ... used in China for over 200 years to treat fever and chills ...
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Exercises in protein structure PowerPoint PPT Presentation
Exercises in protein structure - How many atoms from each subunit are involved (distance 7 ) ... (1L17), what do you predict will happen if L121 is mutated to an arginine? What about R96-- L? ...
How many atoms from each subunit are involved (distance 7 ) ... (1L17), what do you predict will happen if L121 is mutated to an arginine? What about R96-- L? ...
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The Practical Side of Nucleotide Metabolism PowerPoint PPT Presentation
The Practical Side of Nucleotide Metabolism - Anti-Viral Therapies. HIV- Human Immunodeficiency Virus. HSV- Herpesvirus ... Acyclovir as an Anti-HSV Agent. Acyclovar (acycloguanosine)- purine analog ...
Anti-Viral Therapies. HIV- Human Immunodeficiency Virus. HSV- Herpesvirus ... Acyclovir as an Anti-HSV Agent. Acyclovar (acycloguanosine)- purine analog ...
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Arvutid ravimiarenduses PowerPoint PPT Presentation
Arvutid ravimiarenduses - Arvutid ravimiarenduses Mati Karelson RAVIMIARENDUSE KRONOLOOGIA Ravimiarenduse tee M ratakse haigus Isoleeritakse haigusega seotud valk (2-5 aastat) Leitakse ...
Arvutid ravimiarenduses Mati Karelson RAVIMIARENDUSE KRONOLOOGIA Ravimiarenduse tee M ratakse haigus Isoleeritakse haigusega seotud valk (2-5 aastat) Leitakse ...
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Roselyn A. Naranjo PowerPoint PPT Presentation
Roselyn A. Naranjo - Physicochemical Properties of Drugs in relation to Drug Action Roselyn A. Naranjo USPF, College of Pharmacy www.roselynnaranjo.vze.com roselean@gmail.com
Physicochemical Properties of Drugs in relation to Drug Action Roselyn A. Naranjo USPF, College of Pharmacy www.roselynnaranjo.vze.com roselean@gmail.com
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Protein Purification: From industrial enzymes to cancer therapy PowerPoint PPT Presentation
Protein Purification: From industrial enzymes to cancer therapy - Protein Expression and Purification Series Instructors Protein Expression and Purification Series Workshop Timeline Introduction Recombinant protein expression and ...
Protein Expression and Purification Series Instructors Protein Expression and Purification Series Workshop Timeline Introduction Recombinant protein expression and ...
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BIOCHEMISTRY OF FOLATE PowerPoint PPT Presentation
BIOCHEMISTRY OF FOLATE - biochemistry of folate and vitamin b12: ... dna synthesis requires vit b12 cycle #1 cycle #2 folate provides methyl groups by two different cycles methylene-thf: ...
biochemistry of folate and vitamin b12: ... dna synthesis requires vit b12 cycle #1 cycle #2 folate provides methyl groups by two different cycles methylene-thf: ...
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Acquired Specific Immunity PowerPoint PPT Presentation
Acquired Specific Immunity - Each one recognizes only one site of the ... Why not fuse them? ... Fuse the spleen and myeloma cells and you'll find survivors in HAT tissue culture media. ...
Each one recognizes only one site of the ... Why not fuse them? ... Fuse the spleen and myeloma cells and you'll find survivors in HAT tissue culture media. ...
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Antimetabolites ( Sulfonamides ) PowerPoint PPT Presentation
Antimetabolites ( Sulfonamides ) - Mechanisms of resistance to sulfa: - permeability of bacteria to sulfa - production of PABA - Altered dihydropteroate synthase enzyme - Obtained folate by ...
Mechanisms of resistance to sulfa: - permeability of bacteria to sulfa - production of PABA - Altered dihydropteroate synthase enzyme - Obtained folate by ...
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Nucleic Acid Metabolism PowerPoint PPT Presentation
Nucleic Acid Metabolism - Nucleic Acid Metabolism Nucleotides Essential for all cells Carriers of activated intermediates in carbohydrate, lipids and proteins CoA FAD NAD NADP
Nucleic Acid Metabolism Nucleotides Essential for all cells Carriers of activated intermediates in carbohydrate, lipids and proteins CoA FAD NAD NADP
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The%20performance%20of%20NAMD%20on%20a%20large%20Power4%20system PowerPoint PPT Presentation
The%20performance%20of%20NAMD%20on%20a%20large%20Power4%20system - The performance of NAMD on a large Power4 system
The performance of NAMD on a large Power4 system
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Prof. Mohammad Alhumayyd Department of Pharmacology PowerPoint PPT Presentation
Prof. Mohammad Alhumayyd Department of Pharmacology - ... Staphylococcus Saprophyticus Chlamydia trachomatis ,Mycoplasma & N. gonorrhea (limited to urethra, unlike E.coli may be sexually transmitted) ...
... Staphylococcus Saprophyticus Chlamydia trachomatis ,Mycoplasma & N. gonorrhea (limited to urethra, unlike E.coli may be sexually transmitted) ...
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E. coli as a host PowerPoint PPT Presentation
E. coli as a host - E. coli as a host PROs: Easy, flexible, high tech, fast, cheap; . . . . . . but problems CONs Folding (can misfold) Sorting - can form inclusion bodies
E. coli as a host PROs: Easy, flexible, high tech, fast, cheap; . . . . . . but problems CONs Folding (can misfold) Sorting - can form inclusion bodies
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Nucleotide Metabolism PowerPoint PPT Presentation
Nucleotide Metabolism - 9. AICAR transformylase. 10. IMP synthase. Glu, PPi. Gln. PRPP ... (AICAR) (FAICAR) Trifunctional enzyme. Potent inhibitors of purine nucleotide synthesis ...
9. AICAR transformylase. 10. IMP synthase. Glu, PPi. Gln. PRPP ... (AICAR) (FAICAR) Trifunctional enzyme. Potent inhibitors of purine nucleotide synthesis ...
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Malaria pathogenesis PowerPoint PPT Presentation
Malaria pathogenesis - Malaria pathogenesis * * * * * * * * * * * * * * * * * * * * * * Resistance to chloroquine Genetic studies have shown that resistance is linked to the transporter ...
Malaria pathogenesis * * * * * * * * * * * * * * * * * * * * * * Resistance to chloroquine Genetic studies have shown that resistance is linked to the transporter ...
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Diapositive 1 PowerPoint PPT Presentation
Diapositive 1 - Title: Diapositive 1 Author: HP, Client autoris Last modified by: HP, Client autoris Created Date: 2/22/2005 9:47:23 AM Document presentation format
Title: Diapositive 1 Author: HP, Client autoris Last modified by: HP, Client autoris Created Date: 2/22/2005 9:47:23 AM Document presentation format
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Nitrogen fixation and assimilation PowerPoint PPT Presentation
Nitrogen fixation and assimilation - Amino acids are glucogenic, ketogenic, or both. Table 15.2 ... Aromatic amino acids: glucogenic (alanine or fumarate) and ketogenic amino acids (acetoacetate) ...
Amino acids are glucogenic, ketogenic, or both. Table 15.2 ... Aromatic amino acids: glucogenic (alanine or fumarate) and ketogenic amino acids (acetoacetate) ...
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SAR Antidiabetic Agents PowerPoint PPT Presentation
SAR Antidiabetic Agents - SAR Antidiabetic Agents X = O, S, or N
SAR Antidiabetic Agents X = O, S, or N
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Learning Objectives PowerPoint PPT Presentation
Learning Objectives - Title: PowerPoint Presentation Author: karlm Last modified by: Emaneini Created Date: 11/25/2002 2:35:13 AM Document presentation format: On-screen Show (4:3)
Title: PowerPoint Presentation Author: karlm Last modified by: Emaneini Created Date: 11/25/2002 2:35:13 AM Document presentation format: On-screen Show (4:3)
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Pyrimidine Lecture PowerPoint PPT Presentation
Pyrimidine Lecture - To ribose phosphate. Precursors are Glutamine (NH2), Bicarbonate (C) ... Common side effects of DNA inhibitor chemotherapeutics: Gastrointestinal disturbances ...
To ribose phosphate. Precursors are Glutamine (NH2), Bicarbonate (C) ... Common side effects of DNA inhibitor chemotherapeutics: Gastrointestinal disturbances ...
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Protocol for Generation of Stable Cell Lines PowerPoint PPT Presentation
Protocol for Generation of Stable Cell Lines - Protocol for Generation of Stable Cell Lines
Protocol for Generation of Stable Cell Lines
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Wrap up antimalarial treatment PowerPoint PPT Presentation
Wrap up antimalarial treatment - Wrap up antimalarial treatment
Wrap up antimalarial treatment
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Anti-bacteria Medicine PowerPoint PPT Presentation
Anti-bacteria Medicine - Anti-bacteria Medicine Anti-bacteria medicine Antibiotics: The substance derived from fungi and bacteria which can selectively kill or inhibit bacteria growth Anti ...
Anti-bacteria Medicine Anti-bacteria medicine Antibiotics: The substance derived from fungi and bacteria which can selectively kill or inhibit bacteria growth Anti ...
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Pharmacology Summary notes PowerPoint PPT Presentation
Pharmacology Summary notes - Pharmacology Summary notes. Unit 9. 4MedStudents.com. R.E.A. Cytochrom P450. 2D6. - Blockers ... Drugs metabolized by UDP Glucuronyl-Tansferease. ...
Pharmacology Summary notes. Unit 9. 4MedStudents.com. R.E.A. Cytochrom P450. 2D6. - Blockers ... Drugs metabolized by UDP Glucuronyl-Tansferease. ...
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Slayt 1 PowerPoint PPT Presentation
Slayt 1 - Title: Slayt 1 Author: aa Last modified by: m Created Date: 5/19/2006 2:52:13 PM Document presentation format: Ekran G sterisi Other titles: Arial Times Times New ...
Title: Slayt 1 Author: aa Last modified by: m Created Date: 5/19/2006 2:52:13 PM Document presentation format: Ekran G sterisi Other titles: Arial Times Times New ...
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Chapter 6 Protein Function : Enzymes Part 1 PowerPoint PPT Presentation
Chapter 6 Protein Function : Enzymes Part 1 - Chapter 6Protein Function : Enzymes Part 1. This part will get into Enzyme nomenclature and kinetics (rates of catalysis).
Chapter 6Protein Function : Enzymes Part 1. This part will get into Enzyme nomenclature and kinetics (rates of catalysis).
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Antibiotic Resistance PowerPoint PPT Presentation
Antibiotic Resistance - Antibiotic Resistance, its various causes, bacterial mechanisms and possible solutions are discussed in this presentation. All the mechanisms behind each action are explained in schematic representations for easy understandings.
Antibiotic Resistance, its various causes, bacterial mechanisms and possible solutions are discussed in this presentation. All the mechanisms behind each action are explained in schematic representations for easy understandings.
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Department of Biochemistry and Molecular Biology, New Jersey Medical School PowerPoint PPT Presentation
Department of Biochemistry and Molecular Biology, New Jersey Medical School - Irreversible inhibitors bind at the active site of the enzyme and form a ... Doxycycline. competitive inhibitor of collagenase- control of periodontal disease ...
Irreversible inhibitors bind at the active site of the enzyme and form a ... Doxycycline. competitive inhibitor of collagenase- control of periodontal disease ...
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Protein structural element PowerPoint PPT Presentation
Protein structural element - Protein structural element. Yun-Ru (Ruby) Chen ??? Ph.D. The ... Aliphatic. pKa=13.6. cis-trans Isomerization (trans:cis) Non-proyl (1000:1) X-proyl bond (4:1) ...
Protein structural element. Yun-Ru (Ruby) Chen ??? Ph.D. The ... Aliphatic. pKa=13.6. cis-trans Isomerization (trans:cis) Non-proyl (1000:1) X-proyl bond (4:1) ...
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Antifolates, DNA gyrase inhibitors, Novel lipopeptides PowerPoint PPT Presentation
Antifolates, DNA gyrase inhibitors, Novel lipopeptides - Antifolates, DNA gyrase inhibitors, Novel lipopeptides Pawitra Pulbutr M.Sc. In Pharm (Pharmacology) ...
Antifolates, DNA gyrase inhibitors, Novel lipopeptides Pawitra Pulbutr M.Sc. In Pharm (Pharmacology) ...
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Disease PowerPoint PPT Presentation
Disease - Disease
Disease
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DRUG RECEPTORS AND PHARMACODYNAMICS PowerPoint PPT Presentation
DRUG RECEPTORS AND PHARMACODYNAMICS - DRUG RECEPTORS AND PHARMACODYNAMICS graded dose-response relationship In this relationship; percentage of a maximal response is plotted against the log dose of the ...
DRUG RECEPTORS AND PHARMACODYNAMICS graded dose-response relationship In this relationship; percentage of a maximal response is plotted against the log dose of the ...
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