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Pharmacology Summary notes

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Title: Pharmacology Summary notes


1
Pharmacology Summary notes
4MedStudents.com
  • Unit 9

R.E.A
2
Cytochrom P450
Prof. Petroianu
3A4
  • Substrates
  • Macrolide Antibiotics
  • BZD
  • Immune Modulators (cyclosporine)
  • Statin
  • Ca channel Blockers
  • Activators
  • Barbiturates
  • Carbamazepine
  • Glucocorticioids
  • Phenytoin
  • Rifampin
  • St.Johns worts
  • Inhibitors
  • Azole Antifungals
  • Cimetidime
  • Ciprofloxacin
  • Erythromycin
  • Grape fruit

3
N-Acetyle- Transferase (NAT)
Prof. Petroianu
  • Hydralazine
  • Side effects
  • Lupus like Syndrome
  • Neuropathy
  • Isoniazid
  • Side effects
  • - Neuropathy ( Vitamin B6)
  • Seizures ( GABA)
  • Lactic Acidosis
  • Lactic acid Pyruvate
  • Palagra dermatitis, diarrhea, dementia, death)
  • Lupus like Syndrom
  • Procaine-Amide
  • Side effects
  • Lupus like Syndrome
  • Torsades de pointes
  • CNSpsychotic reactions
  • Sulfa Drugs
  • Side effects
  • Stevens Johnson Syndrome
  • Epidermal necrolysis

Drugs Metabolized by N-Acetyle Transferase
4
UDP Glucuronyl-Transferase
Prof. Petroianu
Irinotecan
Acetaminophen Paracetamol
Drugs metabolized by UDP Glucuronyl-Tansferease.
If UDP Glucuronyl-Tansferease was genetically
defected it will lead to hepatotoxicity.
5
G6PD
Prof. Petroianu
Sulfa Drugs
Anti-malarias drugs primaquine
Anti-Microbial drugs chloramphenicol
G6PD protects the RBC from oxidative stress,
deficiency of G6PD will cause distribution of RBC
Anemia Drug s that causes Oxidative
stress in G6PD deficiency
6
Thio-Purine-Methyl-Transferase
Prof. Petroianu
6-mercaptopurine
6- Thioguanine
Azatthiopine
Drugs metabolized by Thio-Purine-Methyl-Tansfera
se. TPMT deficient patients can develop
hematological toxicity
7
Glutathione-S-Transferase
Prof. Petroianu
  • Activators
  • Broccoli
  • Inhibitors
  • ethacrynic Acid
  • Sulfa drugs
  • Anti-malaria drugs (Qunine)

Is an enzyme that will help reduce toxicity
8
Dihydro-Pyrimidine-Dehydrogenase
Prof. Petroianu
Capecitabine
5-Fluorouracil
5- deoxy Fluorouracil
Drugs metabolized by Dihyro-Pyrimidine-Dehydroge
nase
9
ChemotherapyCytotoxic Drugs
Prof. Adem
  • Anti-Metabolites- Methotrexate (
    Dihydrofolate reductase)
  • Flurouracil
  • Cytarabine
  • Mercaptopurine
  • Plant alkaloid
  • Vincristine inhibit mitosis at metaphase
  • Etoposide ( Topoisomerase II)
  • Alkylating Agents
  • (Cause Cross link)
  • Cyclophosphamide
  • Lomustine
  • Cisplatin

Hormones
  • Drugs inhibit sex hormone release
  • Formestain
  • aminoglutathmide
  • Breast tumors

Glucocoticoids Leukaemia lymphoma
Oestrogen Prostate tumors
Tamoxifen (anti-oeastrogen) Prostate tumors
  • GTRH analogues
  • Leuprolide
  • geserline
  • Prostate tumors breast tumor

Flutamide ( Anti-androgens) Prostate cancer
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