Title: Pharmacology Summary notes
1Pharmacology Summary notes
4MedStudents.com
R.E.A
2Cytochrom P450
Prof. Petroianu
3A4
- Substrates
- Macrolide Antibiotics
- BZD
- Immune Modulators (cyclosporine)
- Statin
- Ca channel Blockers
- Activators
- Barbiturates
- Carbamazepine
- Glucocorticioids
- Phenytoin
- Rifampin
- St.Johns worts
- Inhibitors
- Azole Antifungals
- Cimetidime
- Ciprofloxacin
- Erythromycin
- Grape fruit
3N-Acetyle- Transferase (NAT)
Prof. Petroianu
- Hydralazine
- Side effects
- Lupus like Syndrome
- Neuropathy
- Isoniazid
- Side effects
- - Neuropathy ( Vitamin B6)
- Seizures ( GABA)
- Lactic Acidosis
- Lactic acid Pyruvate
- Palagra dermatitis, diarrhea, dementia, death)
- Lupus like Syndrom
- Procaine-Amide
- Side effects
- Lupus like Syndrome
- Torsades de pointes
- CNSpsychotic reactions
- Sulfa Drugs
- Side effects
- Stevens Johnson Syndrome
- Epidermal necrolysis
Drugs Metabolized by N-Acetyle Transferase
4UDP Glucuronyl-Transferase
Prof. Petroianu
Irinotecan
Acetaminophen Paracetamol
Drugs metabolized by UDP Glucuronyl-Tansferease.
If UDP Glucuronyl-Tansferease was genetically
defected it will lead to hepatotoxicity.
5G6PD
Prof. Petroianu
Sulfa Drugs
Anti-malarias drugs primaquine
Anti-Microbial drugs chloramphenicol
G6PD protects the RBC from oxidative stress,
deficiency of G6PD will cause distribution of RBC
Anemia Drug s that causes Oxidative
stress in G6PD deficiency
6Thio-Purine-Methyl-Transferase
Prof. Petroianu
6-mercaptopurine
6- Thioguanine
Azatthiopine
Drugs metabolized by Thio-Purine-Methyl-Tansfera
se. TPMT deficient patients can develop
hematological toxicity
7Glutathione-S-Transferase
Prof. Petroianu
- Inhibitors
- ethacrynic Acid
- Sulfa drugs
- Anti-malaria drugs (Qunine)
Is an enzyme that will help reduce toxicity
8Dihydro-Pyrimidine-Dehydrogenase
Prof. Petroianu
Capecitabine
5-Fluorouracil
5- deoxy Fluorouracil
Drugs metabolized by Dihyro-Pyrimidine-Dehydroge
nase
9ChemotherapyCytotoxic Drugs
Prof. Adem
- Anti-Metabolites- Methotrexate (
Dihydrofolate reductase) - Flurouracil
- Cytarabine
- Mercaptopurine
- Plant alkaloid
- Vincristine inhibit mitosis at metaphase
- Etoposide ( Topoisomerase II)
- Alkylating Agents
- (Cause Cross link)
- Cyclophosphamide
- Lomustine
- Cisplatin
Hormones
- Drugs inhibit sex hormone release
- Formestain
- aminoglutathmide
- Breast tumors
Glucocoticoids Leukaemia lymphoma
Oestrogen Prostate tumors
Tamoxifen (anti-oeastrogen) Prostate tumors
- GTRH analogues
- Leuprolide
- geserline
- Prostate tumors breast tumor
Flutamide ( Anti-androgens) Prostate cancer