Adcc PowerPoint PPT Presentations

Infrastructure@ADCC Technical Expertise Our Areas of Expertise Web solutions GIS Messaging solutions Business mobility BPO/ITES Delivery Models Clientele Delivery ...

SCID mice received 106 HMy2 MM cells by intraperitoneal injection on day 0. ... At day 36 surviving mice were sacrificed and inspected for ... surviving mouse ...

C mediated Ab response. ADCC. CTLs. DTH. Compatibility Tests. ABO. Microcytotoxicity. Pre existing Ab. C mediated. Mixed lymphocyte reaction ...

Bispecific Antibody (BsAb) are antibodies that can simultaneously bind two separate and unique antigens (or different epitopes of the same antigen). The primary application of BsAb has been to redirect cytotoxic immune effector cells for the enhanced killing of tumor cells by antibody-dependent cell-mediated cytotoxicity (ADCC) and other cytotoxic mechanisms mediated by the effector cells.

Removal of Ig-coated organisms (opsonization) or cells (ADCC) ... Hydrogen peroxide. Heightened microbicidal state. IFN- induces expression of FcR on M ...

With the antibody Fc region that triggers antibody dependent cellular cytotoxicity (ADCC) or complement dependent cytotoxicity (CDC) and the cytotoxicity of the ADC payload drug, some ADCs exert a “two-fold” killing efficacy towards targeted cancer cells. Due to their unique nature, ADC in vivo evaluation is of crucial importance since this process provides information regarding their efficacy and safety, which serves as a prerequisite and a guideline for clinical trial design.

The Air Training Corps History of the ATC Origins of the Air Training Corps In 1938 the Air Defence Cadet Corps (ADCC) was formed by a retired RAF Officer; The aim of ...

C lulas con funci n ADCC (citotoxicidad celular dependiente de anticuerpo) ... o timo-dependiente. Nodulos primarios: Grupos esfericos de c lulas. Fol culos ...

Immunoglobulins and Antibody: Structure and Function. January 30, 2001. Outline ... Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) NK cells bind Ag/Ab ...

mature B cell: ... Antibody-dependent cell-mediated cytotoxicity (ADCC) ... Established cell lines (hybridomas) that secrete any antibody that can be raised ...

Provides innate immune system with high degree of ... Defect in IgE-triggered anaphylaxis. No ADCC by NK cells. Signaling cascade - ITAM. New FcR: Fc ...

As the new generation of immunotherapy, ADCs are meticulously constituted bio-macromolecules with high potential in the treatment of cancer and various other diseases. The information gathered from in vitro analysis provides a guideline for ADC optimization and the downstream in vivo ADC assessment. https://www.creative-biolabs.com/adc/adc-in-vitro-analysis.htm

Provides innate immune system with high degree of specificity (Fab portion) ... Defect in IgE-triggered anaphylaxis. No ADCC by NK cells. Fc RIV = Fc RIIIA (h) ...

Recent collaboration with other Arctic Programs ... In 2004, ADCC will be transferring from JOSS, ATLAS and ITEX data sets, to be ...

C lulas, receptores y mecanismos de la Inmunidad Innata. 10.1 Los linfocitos NK: Fenotipo. Funci n. 10.2 Mecanismos de activaci n de las c lulas NK. ADCC ...

National Snow and Ice Data Center (NSIDC) ADCC. NSF. Funding and Organizational Chart ... dichtl@nsidc.org. 5-7 March 2003. 21. Blank. SBI-2 PI Meeting, Miami ...

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viry) nebo nesouc ch abnorm ln intracelul tn proteiny ada funk n odli n ch subpopulac : th1, th2, th17, tfh, treg, tc, nkt, gdt ...

Anti-HIV Cellular Mediated Immunity. Guido Ferrari, MD. Dept. of Surgery. Early Ag: Tat, ... Functional Characterization of cellular mediated immune responses ...

Last modified by: Created Date: 10/8/2000 10:38:51 PM Document presentation format: Company: XXMC Other titles: Times New Roman ...

Humoral Immunity and Complement Robert Beatty MCB150 Humoral Immunity Transfer of non-cell components of blood-- antibodies, complement Humoral immunity = antibody ...

Immunotherapies Vaccines (toxoid, ... [TGF-b] Immunosuppressive agents Corticosteroids (block cellular infiltration, ... treatment of acute graft rejection: ...

BACTERIA CAUSE DISEASE BY SECRETING TOXINS. High Affinity IgG and IgA Can Neutralize Toxins ... Ig Can Block Adherence of Bacteria. IgA at mucosal surfaces. IgG ...

Title: PowerPoint Author: Billgates Last modified by: lwy Created Date: 3/24/2004 8:31:44 AM Document presentation format:

Protein glycosylation Adds another layerof structure and specificity to proteins Can enhance the function of a protein Can extend the lifetime of a protein

Receipient antigen presenting cell. Intact donor MHC molecules. High precursor frequency ... Poorly inhibited by Cyclosporin A. Poorly inhibited by Cyclosporin ...

Tumor Immunology 1. 2. 3.

Monoclonal Antibodies (mAbs) Antibodies (Abs). Also known as immunoglobulins (Ig). Comprised of 2 heavy chains and 2 light chains Monoclonal Abs bind specifically to ...

Title: Author: immun Last modified by: xiaowuhong Created Date: 11/10/2000 8:34:25 AM Document presentation format:

Bio 328 Immunology Immunoglobulins: structure and Function How do Antibodies kill Cancer Cells? Binding to cell surface receptors and preventing their activation.

Bound NK cells release granules with a protein that forms pores on the target ... (Medarex, Abgenix, Kirin) Breedveld, Lancet 2000 355:9205 ...

Title: TK IL-2 RAR Author: hkgh Last modified by: Your User Name Created Date: 3/27/2002 7:02:31 AM Document presentation ...

Hemolytic disease of the newborn is caused primarily by clearance of fetal Rh+ red blood cells that have bound maternal Rh IgG. Cytotoxic clearance of the IgG bound ...

Type IV Delayed Hypersensitivity. Antigen : Chemical , Bacteria , Virus ,Fungus. Antibody : ... Cell death ( tissue necrosis ) Lymphokines * Chemotactic factor ...

Monoclonal Abs bind specifically to a single site (epitope) on a ... (Medarex, Abgenix, Kirin) Breedveld, Lancet 2000 355:9205. 18. 26.02.2004. Antineoplastic ...

Passive Antibody (IVIG, humanized monoclonal antibodies or immunotoxins) ... Recombinant antibodies are less immunogenic and induce less allergic reactions. ...

Mike Bolger KSC CIO ASUS Data Collection The ASUS Project collects Enterprise IT Security Data: Patch Management 80,000+ devices Software Inventory 80,000 ...

A rat myeloma cell line does produce MAb with the bisecting NAcG. Hypothesis: Expression of the rat enzyme in a CHO cell line will add a bisecting ...

Title: PowerPoint Last modified by: Created Date: 4/22/2003 12:01:04 AM Document presentation format:

Physiological state. No. of sites depends on 3-D structure of protein ... glycosylation states. in various mutants. 17. Umana et al. ...

Metastasis. Neoplasm. Oncogene. Sarcoma. Transformation. TSTA. Tumor Immunology ... Expressed by germ line cells. Expressed by specific cell types. Over expressed ...

Hypersensitivity reactions Hypersensitivity reactions excessive undesirable (damaging, discomfort producing and sometimes fatal) reactions produced by the normal ...

Title: Antibody production Author: Your User Name Last modified by: acadpm01 Created Date: 11/7/2006 6:45:15 AM Document presentation format: On-screen Show (4:3)

Title: Kuby Immunology 6/e Author: Kindt, Goldsby, Osborne Last modified by: sb Created Date: 12/24/2002 1:08:46 AM Document presentation format: On-screen Show (4:3)

... transfectants of BHK cells (BHK = baby hamster kidney) Works: ... Mouse and hamster cell lines used for commercial ... data available for Chinese hamster ...

Risposta immunitaria ai tumori Immunosorveglianza: i tumori possono esprimere proteine nuove che possono essere riconosciute dal nostro sistema immunitario in quanto ...

A subsequent exposure to the same allergen cross links the cell-bound IgE and ... Intradermal skin test with multiple positive allergen responses ...

Title: Author: Wang Hui Last modified by: Created Date: 10/6/2000 8:09:19 AM Document presentation format

Purpose: to see in vivo the effect of loss of. a particular function in the body ... In vivo assays. Graft-vs-host. If graft is immunocompetent and injected into ...

some antiserum was first incubated with. ovalbumin and then electrophoresed; ... Monomer in serum, multimer elsewhere. helps protect portals of entry in body ...

... (ITAM), activating receptor -KLR(killer lectin-like receptor): Heterodimer of CD94 & NKG2 (C type lectin) CD94: short cytoplastic region, no signal ...

Mouse and hamster cell lines used for commercial production lack the ... Chinese hamster ovary cell mutants with multiple glycosylation ...

Herceptin (trastuzumab) 1 target 4 mechanisms of action HER2: role in breast cancer Human epidermal growth factor receptor 2 (HER2) is a transmembrane protein and ...

Title: yjl Last modified by: Created Date: 1/1/1601 12:00:00 AM Document presentation format: Other titles: Arial ...