Back

1
?????
?????????????
??? ????(?)(9?12)

• ??
• ??
• ?????

2
?????
?????????????
Back
3
?????
?????????????
Back
4
?????
?????????????

• ??????
• ????
• (1)??????(PRR)
• (??????)
• ???????????(PAMP)

Back
5
?????
?????????????

• PRR
• ?????(MR)
• ?????(SR)
• Toll???(TLR)

Back
6
?????
?????????????
Back
7
?????
?????????????
Back
8
?????
?????????????
Back
9
?????
?????????????
(2) ????? FcR CR
Back
10
?????
?????????????

• 2. ??????????????
• ????????
• ?????????
• ?????????

Back
11
?????
?????????????
3. ?? (1)?????? M?IL-1?IL-6?TNF (2)?????????
???? ????TNF-????? ADCC Ab??
12
?????
?????????????
(3) ??????? (4)????
13
?????
?????????????
???????(dendritic cell,DC) ??
?? ????DC(MDC)?DC1
???DC(LDC)?DC2
Back
14
?????
?????????????
Back
15
?????
?????????????
Back
16
?????
?????????????

• DC??
• ??????,??????
• ????

Back
17
?????
?????????????
18
?????
?????????????
????????(Natural killer cell,NK??)
?? 10 ???????????? ?? CD16??(CD3) ??????????? ?
??????(LGL) ??IFN-??TGF-ß,????
Back
19
?????
?????????????
Back
20
?????
?????????????

• ??
• ?????
• ??ADCC
• ????

21
?????
?????????????

• 2. ????
• (1)?????
• ??MHC I???
• KIR KIR2DL?3DL(ITIM)
• KLR CD94-NKG2A
• ??????
• ???????

22
?????
?????????????
Back
23
?????
?????????????
Back
24
?????
?????????????
25
?????
?????????????
(2)???? ???MHC I???
KIR2DS-DAP12(ITAM) NKG2D-DAP10( ITAM )
????????(NCR) NKP46.30CD3??
NKP44DAP12 ( ITAM )
26
?????
?????????????
3. NK??????? perforin?cytolysis granzyme?TNF-?
?apoptosis FasL ?apoptosis
27
?????
?????????????

• ??NKT??
• NK1.1?CD4-?CD8-
• ?????
• ????

28
?????
?????????????
???????? ????? ????????????? I ?????
29
(No Transcript)