MHC??

1
????????????
2

• ??????????????????????,???????????????????????????
  ???
• ???????????????????,????????????

3

• ??? ?????????????????
• ????????????
• ??
• MHC??
• ??????
• ????

4
??????????

• ?? ??????????????????????????????,???????????????
  
• ???????????????????,?????????????????????????????
  ??(GPI)????,????????????????????????

5

• ??????????????????,????????????IgSF?CKRF?C-Lectin
  SF???????TNFSF?TNFRSF
• CD ???????????????,?????????????????????????CD

6
???CD??(?)?T???????????????CD???
7

• CD3 CD3?T??????TCR / CD3???,???T???????????,?TC
  R?????????????

8

• CD3?????d?e??(zeta)??(eta)?????

9

• CD3?d?e???IgSF,?????????????TCRaß?TCR?d???????????
  ???,????TCR-CD3????CD3?????????????????????,????
  ???

10

• CD4 ????????,??????IgSF??,??4????,CD4???????????
  ??MHCII??????????????V?????HIV????
• CD4?T??TCR-CD3?????????,??????APC?????MHCII?????,?
  ????p56lck?????,???????
• CD4 T??????T??(Th)

11

• CD8 ??aß?????????????,???????IgSF?
• a?V???MHC I???????a3????,?????p56lck?????,??T?????
  ????????
• CD8?????T???CD8??T???????,?????????-MHC???????????
  

12

• CD2 ????????????2(LFA-2),CD2????????CD58(LFA-3)?
• ?????????????????
• CD2?CD58??,??T??????????,??????T???APC?????????,??
  CD2??????????

13

• CD58 ??LFA3,?????APC???????CD2????,??T??????????
• CD28 ?????????????,CD28?????????????????CD28??CD
  4T???50 CD8 T????????????B???CD28????B7-1?B7-2?
  B7?????B???APC????

14

• CTLA-4 ??CD152,??????T??,????T??????????B7??,??T?
  ?????????????CD28??T?????,?????,?CTLA-4??????,????
  ????????????
• CD40L ?CD154,????????CD4 T?????CD8
  T????dT??,?B?????CD40??????B?????

15
(?)?B?????????????CD??

• CD79a/CD79ß ??Iga/Igß,????????B?????????,?B?????
  ????BCR??Iga/Igß -BCR???,???????????????????B?????
  ???SH2???,?????BCR????????

16

• CD19 ?????????B???????????,?B????????CD19?CD19/CD
  21/CD81???????????,????????,??B?????
• CD21 ??CR2?EB????,??????B??????????,???????????,?
  B????????CD21?iC3b?C3d??,??B????????????????

17

• CD80/CD86 ?B7-1/B7-2,????????????CD80??CD86?,??T?
  B??????????CD80/86?CD28???T????????????????(co-sti
  mulating signal)
• CD40 ?????B??????????????????????????????????????
  ??CD40L-CD40????B?????????????????

18
(?)?????Fc???

• CD64 Fc?RI,?????-????????????????IgGFc?????ADCC
  ?IC????????????????IL-1?IL-6?TNF-a????
• CD32 Fc?RII, ????,??????IgGFc???????????????????
  ?????????? Fc?RII-B???????

19

• CD16 Fc?RIII,??????IgGFc??,????IgG1?IgG3?
  ????ADCC???
• CD89 ?FcaR,?????????????????????,??T?B??????????
  ??????????????????ADCC?
• FceRI ?IgE??????,??I??????

20

• CD23 FceRII,???sCD23,???B???????,?IgE????????CD2
  3??IgE?IgE????,???B???IgE???sCD23?B??CD21?????IgE
  ???

21
??? ????

• ???????????????????????????????
• ???????-???????????,????????????????????????????
• ????????????????????????????????????????????

22
???????

• ?aß?????????????????
• ??14?a????8?ß???,?ß????????????8???
• ?????????????,????????????????????????????????????
  ??

23
??????????

• ???????????????????,???Ig???????,???1????IgV??C???
  ??????????????????

24
???????

• ?????????????,??C????(CL)????EGF??????????????????
  CL??????????????
• ?L?P?E????????
• ???????????

25
????????

• ??????????????????????????????????????????????????
  ????

26
????????

• PNAd
• CLA
• CD44

27
(No Transcript)
28
?????????

• ???????????????????
• ?????????????????
• ??????

29
??? CD???????????????????

• ??????
• ?????????
• ????????????

30
???

• 1 ??????????CD????????????
• 2 ??????????????
• 3 ??CD?????????????????