AntiHIV Cellular Mediated Immunity

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Anti-HIV Cellular Mediated Immunity
Guido Ferrari, MD Dept. of Surgery
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HIV-1 Life Cycle and Immune Response
Early Ag Tat, Rev, Nef
Late Ag Pol, Gag, Env

CTL killing None ADCC activity Neut-Ab activity
CTL killing No virus release Highly effective
CTL killing Decrease virus release Partially
effective ADCC activity
CTL killing Too late Neut-Ab activity
Adapted from A. McMichael Ann. Rev. Imm. 1997
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• Activities
• Functional Characterization of cellular mediated
  immune responses in vaccinees (HIV Vaccine Trial
  Network and RO1), in acutely infected
  individuals, and role of co-pathogens in HIV
  infection CAPRISA, Dr C. Gray ISAAC, Dr J.
  Bartlett
• Assay standardization (ELISPOT, ADCC) and
  development (ICS and LPA) for clinical trials
  HIV Vaccine Trial Network
• Training programs for Developing Countries
  (ELISPOT and ICS workshop) NIAID/NIH and WHO

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Antibody Dependent Cellular Cytotoxicity