Principles%20of%20Immunology%20Tumor%20Immunology%204/25/06

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Principles of ImmunologyTumor Immunology4/25/06
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Word/Terms List

• AFP
• Benign
• Carcinoma
• CEA
• Leukemia
• Lymphoma
• Malignant
• Metastasis
• Neoplasm
• Oncogene
• Sarcoma
• Transformation
• TSTA

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Tumor Immunology

• Benign vs. malignant tumors
• Types of neoplasms
• Carcinomas
• Leukemias/lymphomas
• Sarcomas

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Cell Transformation

• Characteristics
• Nutritional changes
• Lack of contact inhibition
• Immortality

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Chemicals and Cancer

• Mitogens
• Mutagens
• Carcinogens

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Genes and Cancer

• Oncogenes
• Proto-oncogenes

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Tumor-specific Transplantation Antigens

• Origin of TSTAs
• Point mutations
• Expressed by germ line cells
• Expressed by specific cell types
• Over expressed
• Post translation changes
• Viral oncogenes

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Oncofetal Antigens

• Alpha fetoprotein (AFP)
• Carcinoembryonic antigen (CEA)

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Tumors of the Immune System

• Leukemias
• ALL
• AML
• CLL
• CML
• Lymphomas

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Tumors and Viruses

• Hepatitis B
• Human papilloma virus(HPV)
• Epstein Barr Virus

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Tumors and Evasion of the Immune System

• Low immunogenicity
• Modulation by antibodies
• Tumor secreted suppressors

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Immune Response to Tumors

• Cells
• NK
• CTLs
• Macrophages
• Cytokines
• Interferon
• TNF

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Immunotherapy Against Tumors

• ADCC
• Toxin conjugation
• Radionuclide conjugation