CELLULAR MECHANISMS OF ALLORECOGNITION

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CELLULAR MECHANISMS OF ALLORECOGNITION
MHC Class II
TCR


ADCC
CD4

Donor


Inactivation
IL-2

T Cell

Cell
a
-IFN
g
Receipient antigen presenting cell

CD4

Recipient

Antigen
T Cell


Killing
Presenting
b
Cell
CD8

Cytotoxic

T Cell

B

Antibodies
Cell
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DIRECT ALLORECOGNITION
INDIRECT ALLORECOGNITION
INDIRECT ALLORECOGNITION
DIRECT ALLORECOGNITION

Donor MHC peptides


Donor MHC peptides


Intact donor MHC molecules

Limited TCR usage

Limited TCR usage

Diversity of TCR specificities

Diversity of TCR specificities

High precursor frequency

oligospecific response


High precursor frequency

oligospecific response


Poorly inhibited by Cyclosporin A

Inhibited by Cyclosporin A

Poorly inhibited by Cyclosporin A

Inhibited by Cyclosporin A
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