Presentazione di PowerPoint

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SAPUVETNET
BOTULISM Research of an outbreak of Botulism type
A in Argentina.

Case study
Epidemiological paper based on Jeanette
K.Stehr-Green, CDC, Atlanta (USA) work and the
Villar and colleagues publishing (1999) Outbreak
of Type A Botulism and Development of a Botulism
Surveillance and Antitoxin Release System in
Argentina. JAMA, 281 1334-1340.
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What is Botulism?

• Neuro paralytic disease, frequently fatal. It
  results from the ingestion of the botulinum toxin
  developed by the bacterium Clostridium botulinum
  and other bacteria.
• This microrganism is strictly anaerobic and its
  spores are widely distributed among animal
  intestines, soil and river and sea banks.
• The botulinum toxin is a powerful poison and is
  also termolabil.

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Background

• It is told that the outbreak affected bus drivers
  which had eaten matambre (rolled beef with
  vegetables and boiled egg).
• On January, 10 bus drivers got sick with
  diarrheic symptoms, blurred vision, dysphagia,
  double vision, motor weakness, one of them showed
  shortness of breath...
• (cont.)

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• cont. ...
• A cohort study was performed for 22 company
  drivers, 11 of them, had eaten matambre.
• Type A toxin was found on 3 of the analysed
  patients.
• All patients received the anti toxin provided by
  the CDC.

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...the CDC intervention

• By the time the anti toxin is required the
  Centers for Disease Control and Prevention (CDC),
  Atlanta, Ga. USA, participate in the outbreak
  investigation.
• The research is done by an epidemiological team
  which included epidemiologists, microbiologists,
  food, sanitation and environmental experts.
• Critical points are identified for contamination,
  survival and microbial growth and next steps are
  discussed.

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Epidemiological exercise

• Based on this material, Jeanette K. Stehr-Green
  from the CDC along with a support team prepared a
  thorough, detailed and extended case study where
  they describe the procedures and policies on the
  outbreak research and on the prevention and
  control measures set up.

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SAPUVETNET

• Based on the fact told on this papers and
  modifying and simplifying the data for didactical
  reasons, we have re formulated the problem and
  have prepared a case study adapted to SAPUVETNET
  goals.
• The main goals of this job (SAPUVETNET case
  study)
• Understand the sanitary importance of botulism
  outbreaks.
• Take immediate control and prevention measures in
  order to avoid the spreading of the outbreak.
• cont

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SAPUVETNET

• (cont.)
• Identify all food involved, all deficiencies that
  allow the outbreak and the critical points to
  take into consideration in order to prevent
  future incidents.
• Apply the research methodology for outbreak
  investigation.
• Emphasize the importance of sanitary and feeding
  education at all levels.
  

Case study developed by a member of SAPUVETNET II
University of Salvador, Pilar-Buenos Aires
(Argentina)
Contact Dora Dobosch E-mail ddobosch_at_pccp.com.ar