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La scienza delle misure chimiche e qualità della
vita Mario Gallorini I.N.R.I.M Unità di
Radiochimica e Spettroscopia c/o Università degli
Studi di Pavia
Torino - 25 Gennaio 2007
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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EUROTERVIT - JRC- Ispra 1990-2000
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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1.3

120

2.1

Ce

25

80

87

Co

3.7

25

80

Cr

50

3200

312

Cs

0.7

1.3

17.2

Fe

170
0

30000

2640000

Hg

lt 10

17

90

Ir

0.02

0.02

0.2

Ni

135

450

600

Rb

37

140

4775

Sb

22

35

230

Ta

2

14

13

Zn

lt30

120

12130

INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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The application of the Neutron Activation
Analysis for trace metals determination in human
brain tissues and substantia nigra neuromelanin
In human brain many transition metals are
necessary for important biological processes, and
alterations in their homeostasis can produce
neurotoxic effects. Toxicity pathways frequently
involve oxidative stress through an increase of
free radicals production (redox- reactions). The
subsequent damages or death of cells can lead to
neurodegenerative diseases, such as Parkinsons
Disease (PD) and Alzheimer Disease (AD)
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Trace metals and human health Parkinson disease
Trace elements analysis in human brain tissues is
an important step in understanding the PD
pathogenesis. Thanks to a controlled separation
procedure, NM was isolated from SN with no metal
contamination. NM showed a great ability to bind
large amounts of metals, especially Fe,
suggesting that NM can play a protective role for
brain neurons against the free toxic radicals
deriving from redox active metal ions. Fe and Cu
concentrations in brain tissues increase along
with aging in normal subjects.
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Human substantia nigra in parkinsonian (A) and in
normal subject (B)
A
B
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Substantia nigra pars compacta of normal (A)
and parkinsonian subjects (B)
A
B
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Trace metals in human brain tissues and their
neuromelanines
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Biochemical Pharmacology, Aug 166(3),
pp.489-94, (2003). Pigment Cell Res.,
17(6)610-7., Dec (2004).
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Fe
Cu
SN
LC
LC
LC
LC
LC
LC
Cu
SN
Proc Natl Acad Sci U S A.101(26)9843-8. Epub
Jun 21, (2004)
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Radiotracers in vivo experiments
Nuclear reaction p, xn Nat Ti 48 V
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Toxic metals in the environment - K and P
comparison of CCQM IAWG (2006)
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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As in shellfish
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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FOOD ANALYSIS TRACE METALS DETERMINATION IN
TOMATO PASTE
Analytical techniques and procedures for
Cadmiun determination
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
 
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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with PM10 concentration more than 75 mg/m3
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Air particulate matter collected onto filters
Stage 1 (6.0-9.0 ?m)
Stage 5 (1.08-2.15 ?m)
Total Suspended Particle (TSP)
Stage 8 (0-0.41 ?m)
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Reference Materials for life science Trace
elements in air particulate matter PM 2.5
NIST 2783 Air Particulate on Filter
Media
Lab. 7 IMGC Lab.12 NIST
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Reference Materials for life science Trace
elements in air particulate matter PM 2.5
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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Gaithersburg, MD 20899 Certificate Issue Date
2 January 2002
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia
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YES !!
INRIM Unit of Radiochemistry and Spectroscopy c/o
University of Pavia