Mekanisme Kerja Hormon

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Mekanisme Kerja Hormon

• dr. Susila Sastri M.Biomed
• Biokimia FK-Unand

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Hormone
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Struktur Kimia Hormon

• Polipeptida
• Insulin
• Glucagon
• Derivat asam amino (amin)
• Epineprin
• Serotonin
• Tyroxin

• 3. Steroid (derivat kolesterol)
• Aldosteron
• Cortisol
• Retinoic acid
• 4. Eicosanoid (polyunsaturated
• acid, (20atom C)
• Prostadglandin E
• Thromboxane A2

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Simple Intracellular Extracelluler Signaling
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Hormon Action
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Hypophise Anterior
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Neurohormone
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Cell Communication

GAS MOLECULE
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Second messenger
Small molecules synthesized in cells in
response to an external signal are the second
messengers, which are responsible for
intracellular signal transduction Ca2, DG,
Cer, IP3, cAMP, cGMP
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Receptor
Receptors specific membrane proteins, which
are able to recognize and bind to corresponding
ligand molecules, become activated, and transduce
signal to next signaling molecules A.
Membran B. Intra Sel Glycoprotein or
Lipoprotein
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Kelenjer-Hormon-Target Sel
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1. Membrane receptors
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Signal transduction mediated by membrane receptor

• cAMP dependent-protein kinase A pathway
• cGMP dependent PKG pathway
• Ca2 dependent PK pathway
• Tyrosine protein Kinase pathway
• NF-?B pathway
• TGF- ßpathway

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Membrane Receptor
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Cyclic AMP
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Mekanisme Signal Tranduksi

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Hormon-2nd Massengger- Enzim
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Inositol triphosphate System
PLC phospholipase C PIP2 phosphoinositol DAGdia
cylgliserol IP3inositol triphosphat PKC
phosphokinase C
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Intracellular receptor (DNA transcription
regulated receptor)

• Steroid Hormone, VD3, Thyroxine
• Cytosolic R glycocorticosteroid H
• Nuclear R thyroxine, estrogen,
  androgen, progesterone

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Hormon - Receptor

• highly specificity
• highly affinity
• saturation
• reversible binding
• special function model

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Control of receptor activity

• Phosphorylation or dephosphorylation of R
• Phospholipid of membrane
• Enzyme catalyzed hydrolysis
• G protein regulation

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Thyroid Mechanism of Action
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Adrenaline Mechanism of action
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ACTH Mechanism of Action
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Aldosteron Mechanism of Action
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Estrogen Mechanism of Action
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Androgen Mechanism of Action
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Insulin Receptor
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Insulin Action
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Glucagon
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GH/ STH
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