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A MICELLAR LIQUID CHROMATOGRAPHIC METHOD FOR
QUALITY CONTROL OF PHARMACEUTICAL PREPARATIONS
CONTAINING TRICYCLIC ANTIDEPRESSANTS GAMM
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INTRODUCTION Tricyclic antidepressants (TCAs) are
drugs used in the treatment of depression and
other kinds of disorders such as phobias,
obsessive syndromes, crisis of anguish, states of
anxiety, etc. The proposed method that uses
micellar solutions of cetyltrimethylammonium
bromide (CTAB) as mobile phase and UV-detection
is rapid and reproducible. Samples preparation
only required solution and adequate dilution with
the mobile phase before injection into the
chromatographic system.
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Procedure
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Figure 1. Chromatograms of some of the
pharmaceutical preparations analyzed a)
Survector , b) Nobritol , c) Tryptizol , d)
Mutabase , e) Anafranil (injection solution),
g) Sinequan , h) Tofranil, i) Deanxit and j)
Tropargal .
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Cont.
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