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Toxoplasma Gondii

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Title: Toxoplasma Gondii


1
Toxoplasma Gondii
2
Classification toxoplasma gondii Phylum -
Protozoa Class - Sporozoa Order - Eimeriina
Family - Toxoplasmatidae Genus - Toxoplasma
gondii
3
  • Introduction
  • Toxoplasma gondii is an intestinal coccidium
    that parasitizes members of the cat family as
    definitive hosts and has a wide range of
    intermediate hosts. Infection is common in many
    warm-blooded animals, including humans. In most
    cases infection is asymptomatic, but devastating
    disease can occur.

4
Morphology and life cycle
1-Trophozoite - 2- Cyst -
In Intermediate hosts
3- Oocyst - 4- Schizonte - 5-
Gametogenic-
In Definitive hosts
5
FIGURE -1- Trophozoite
6
FIGURE -2- Sexual states of Tgondii
7
Figure-3- Toxoplasma gondii is transmitted.
8

  • Cysts ingested by cat


  • Oocyst in feces
  • In feces

  • Sporoblast

  • sporocyst


  • Sporozoites
  • oocust
  • Development
  • Mutureoocyst
  • Zygote
  • Reproduction (endodyogeny)




  • ???? ????
  • ??

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9
Pathogenesis Congenitally A- Intra cerebral
calci fication ???? ???? ???? B- Chorioretinitis
?????? ???????? ???????? C- Hydro cephalus ????
????? ?? ????? D- Encephalitis ??????
?????? Acquired A- Lymphodenitis ( ??? ???
?? ?????? ??? ???? ????? ) ?????? ?????? B-
Acute infection Example - Encephalomyelitis????
?? ???????
Pneumonitis ?????? ?????
Nyo carditis
?????? ?????? ??????? C- Chronic Toxoplasmosis
(????-????? ?????-??? ????)
10
Diagnosis Diagnosis is based on
serology by - Inhibition Fluorecent anti
body test . ELISA test
Indirect haemaglutination test And on
histologic examination of tissue . Treatment
- 1-Pyrimethamine 25mg every day (3-4) weaks
. 2- Sulfonamides . 3- Sulfadiazine . 4-
Sulfamethazine and sulfamerazine
11
Figure-4- Girl with hydrocephalus due to
congenital toxoplasmosis.
12
Figure-5- Girl with hydrocephalus due to
congenital toxoplasmosis.
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