Title: Toxoplasma Gondii
1Toxoplasma Gondii
2Classification toxoplasma gondii Phylum -
Protozoa Class - Sporozoa Order - Eimeriina
Family - Toxoplasmatidae Genus - Toxoplasma
gondii
3- Introduction
- Toxoplasma gondii is an intestinal coccidium
that parasitizes members of the cat family as
definitive hosts and has a wide range of
intermediate hosts. Infection is common in many
warm-blooded animals, including humans. In most
cases infection is asymptomatic, but devastating
disease can occur.
4Morphology and life cycle
1-Trophozoite - 2- Cyst -
In Intermediate hosts
3- Oocyst - 4- Schizonte - 5-
Gametogenic-
In Definitive hosts
5FIGURE -1- Trophozoite
6FIGURE -2- Sexual states of Tgondii
7Figure-3- Toxoplasma gondii is transmitted.
8-
Cysts ingested by cat -
-
- Oocyst in feces
- In feces
-
Sporoblast -
sporocyst -
Sporozoites - oocust
- Development
- Mutureoocyst
- Zygote
- Reproduction (endodyogeny)
-
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9Pathogenesis Congenitally A- Intra cerebral
calci fication ???? ???? ???? B- Chorioretinitis
?????? ???????? ???????? C- Hydro cephalus ????
????? ?? ????? D- Encephalitis ??????
?????? Acquired A- Lymphodenitis ( ??? ???
?? ?????? ??? ???? ????? ) ?????? ?????? B-
Acute infection Example - Encephalomyelitis????
?? ???????
Pneumonitis ?????? ?????
Nyo carditis
?????? ?????? ??????? C- Chronic Toxoplasmosis
(????-????? ?????-??? ????)
10Diagnosis Diagnosis is based on
serology by - Inhibition Fluorecent anti
body test . ELISA test
Indirect haemaglutination test And on
histologic examination of tissue . Treatment
- 1-Pyrimethamine 25mg every day (3-4) weaks
. 2- Sulfonamides . 3- Sulfadiazine . 4-
Sulfamethazine and sulfamerazine
11Figure-4- Girl with hydrocephalus due to
congenital toxoplasmosis.
12Figure-5- Girl with hydrocephalus due to
congenital toxoplasmosis.