???? ??? Hafnia alvei ??? 1? ???, ???, ???, ??? ????? ???? ???????

1
???? ??? Hafnia alvei ??? 1????, ???, ???,
???????? ???? ???????

• ?? Hafnia alvei? ???? ?? ????? ????????,
  Enterobacteriaceae ?? ???. ?? ??, ??, ??? ? ???
  ?? (?? ?)? ??? ???? ??? ???? ??? ? ??. ???? ?? ??
  ??? ??? ???, ?? ???? ??? ????. ????? ????,
  ????????, ???? ?? ????? ?? ???? ?? ????. ??,
  ????, ???, ????, ???, ??, ?????? ?? ??? ???? ???
  ????? ?? ??? ?? ??. ???? ?? ? ?? ??? ??? ???? ???
  H. alvei? ?????? ????? ??.
• ?? ??? 1?? ?? ??? ?? ? ? ???? ?????, ?? 3????
  ?? ??? ????? ?? ?????. ????? ??? 10.7 g/dL, ????
  23,800/µL (??? 90, ??? 7, ?? 3), ????
  261,000/µL??? ???? ??????(AST / ALT / LD / ALP /
  GGT, 592 / 586 / 2412 / 721 / 198 U/L)? ?????. ??
  ?? ??? ??? 3?? ?????? ?? ? ??? ??? ?????. ? ??
  MacConkey ???? ??? ??? ???, ???? ??? ??????
  oxidase ??, TSI ???? ?? ???, ?? ??, ?? ???, H2S
  ?????, ??? ??, indole ??, ornithine
  decarboxylase? lysine decarboxylase ??, citrate
  ?????. Vitek GNI card (bioMerieux, Hazelwood, Mo,
  USA)? ??? ?? 99 H. alvei? ?????. Vitek GNS-433
  card? ??? ??????????? cefazolin? ????? ??? ??
  ?????(amikacin, ampicillin, ampicillin-sulbactam,
  aztreonam, cefepime, cefoxitin, ceftriaxone,
  ciprofloxacin, gentamicin, imipenem,
  piperacillin-tazobactam, tobramycin,
  cotrimoxazole)? ??????. ??? ?? ???? ???
  cefotaxime?? ?????? ?? 4? ? ????? ?????.
• Table 1. Biochemical reactions of Hafnia alvei
  isolates
• --------------------------------------------------
  --------------------------------------------------
  ---
• Test
  positive of H. alvei
  Isolates
• --------------------------------------------------
  --------------------------------------------------
  ---
• Oxidase, Kovacs
  0
  -
• Lysine decarboxylase
  100
  
• Ornithine decarboxylase
  98
  
• Lactose fermentation
  5
  -
• Glucose fermentation
  100
  
• Gas, glucose
  98
  
• Indole
  0
  -
• Urease
  4
  -
• Voges-Proskauer
  85
  
• Citrate, Simmons
  10
  -
• H2S
  0
  -

• Table 2. Clinical features of 82 patients with
  extraintestinal infection caused by Hafnia alvei
  (literature review)
• --------------------------------------------------
  ---------------
• Characteristics No.
  () of patients
• --------------------------------------------------
  ---------------
• MaleFemale
  32 (39)/50 (61)
• Specimen Respiratory tract 42
  (51)
• Intraabdomen
  13 (16)
• Urogenital tract
  10 (12)
• Blood
  11 (13)
• Others
  6 (8)
• Underlying condition Malignancy 24 (29)
• Surgery
  23 (28)
• Trauma
  10 (12)
• 
  Pancreatitis 4 (5)
• COPD
  5 (6)
• AIDS
  3 (4)
• Others
  5 (6)