PARAMYXOVIRIDAE

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PARAMYXOVIRIDAE

• PETER H. RUSSELL, BVSc, PhD, FRCPath, MRCVS
• Department of Pathology and Infectious Diseases,
  The Royal Veterinary College,
• Royal College Street,
• London NW1 OTU.
• E-mail Web site

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ObjectiveStudents should be able to

• describe the importance of fusion protein for
  virus penetration and vaccination.
• realise that respiratory syncytial virus is
  still a primary virus of calf pneumonia
• describe how distemper virus causes disease in
  dogs and how it is controlled.

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Introduction
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Classification

• 3 Genera Paramyxovirus Pneumoviruses
  Morbilliviruses.

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Structure
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Cultivation and cytopathic effect

• HA in eggs, syncytia in tissue culture.

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Cell tropism in vivo
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Genus PARAMYXOVIRUS

• NEWCASTLE DISEASE VIRUS, (AVIAN PARAMYXOVIRUS 1)

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MURINE PARAINFLUENZA-1

• (SENDAI VIRUS)

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BOVINE PARAINFLUENZA -3 (PI -3)
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BOVINE PARAINFLUENZA -3 (PI -3)

• (cont.)

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PARAINFLUENZA-5 (PI-5)
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Genus PNEUMOVIRUS,BOVINE RESPIRATORY SYNCYTIAL
VIRUS (BRSV)
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Genus PNEUMOVIRUS,BOVINE RESPIRATORY SYNCYTIAL
VIRUS (BRSV)

• (cont.)

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Genus MORBILLIVIRUS

• DISTEMPER VIRUS (CDV)

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Genus MORBILLIVIRUS

• DISTEMPER VIRUS (CDV)
• (cont.)

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Genus MORBILLIVIRUS

• DISTEMPER VIRUS (CDV)
• (cont.)

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RINDERPEST

• (Cattle plague)

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RINDERPEST

• (Cattle plague)
• (cont.)

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PESTE DE PETIT RUMINANT
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EQUID PARAMYXOVIRUS

• ( alias Hendra virus Hendra is a suburb of
  Brisbane)

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NIPAH VIRUS
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Summary

• 3 genera of paramyxoviridae occur para-,
  morbilli- and pneumo- viruses
• The isolates are monotypic because they have an
  unsegmented genome and conserved antigens on the
  fusion protein.
• NDV is a serious notifiable disease of poultry.
• BRSV is the most common cause of calf pneumonia.
  Vaccines limit disease but do not prevent
  infection and some exacerbate disease by immune
  complex disease.
• CDV was the major pathogen of dogs but has been
  controlled in the UK by vaccination.
• A variety of unexpected infections of man and
  wildlife have occurred.