Poxviridae

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Poxviridae
Variola (Smallpox) Vaccina
Orf (sheep)
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Herpesviridae
Bovine herpesvirus Herpes simplex virus
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Adenoviridae
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Parvoviridae
Canine Parvovirus in feces
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Retroviridae
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Myxo and Paramyxoviridae
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Rhabdoviridae Coronaviridae
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A Helical nucleocapsid Tobacco Mosaic Virus
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An Icosahedron One of 5 Platonic solids
Tetrahedron, Cube, Octahedron Icoshedron,
Dodecahedron 12 vertices 20 faces, 30 edges In
theory, the faces can be subdivided into
triangles Triangulation number T h2 hk
k2, where h and k are 0 or integers T
1,3,4,7,9,12,13,16,25
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An Icosahedral subunit or capsomere which
theoretically could occupy an identical position
on the icosahedron
The eight stranded anti-parallel double
beta-pleated sheet (or sandwich) Viruses are
similar but not identical to icosahedra Instead
of perfect T numbers some icosahedron-like viral
capsids have P numbers or pseudo T numbers The
capsomeres occupy Quasi-equivilent positions
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Triangulation number
Capsomeres (T) X 60
T1 T4 T9
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An Icosahedral subunit or capsomere which
theoretically could occupy an identical position
on the icosahedron
Polio virus T3 virus
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Examples of ribbon structures of Capsomeres
Similar 8 stranded beta sheet structure
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Actual 3D structures Note 5-fold vertices
T16 But here is a 6-fold structure
P7
T13 or 7 and T1 (2?) (Double
shelled) T4 T3 or P3
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Non-identity of positions of subunits or
capsomeres
P7 T3 Polio Papilloma T25 Adeno
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The Canyon hypothesis of Picornaviruses
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Phages, Bacteriophages Complex Structures
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Enveloped Virus StructuresHerpesviridae ds DNA
Togaviridae ssRNA Flaviridae
ssRNACoronaviridae ssRNARetroviruses
ssRNANegative Strand viruses
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Family Togaviridae Ross River, Sindbis T4 inner
icosahedron 4 x 60 240 capsomeres
T4 Glycoprotein Arrangement 240 spikes
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Family Togaviridae Ross River, Sindbis
Note 1) the trimeric nature of the glycoprotein
spike 2) The transmembrane region that links to
the icoshedron
T4 Glycoprotein Arrangement (E1 E2)3
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Family Flaviviridae Dengue, WNV T3 inner
icosahedron
Note 1) the trimeric nature of the glycoprotein
spike changes 2) No transmembrane region links
to the icoshedron
No icoshedral or Glycoprotein Triangulation
number Arrangement matures to (prM E)3 ? E2
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Toga E1
Similar structure and genes Both have fusion
peptide regions
Flavi E
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The Negative Strand Enveloped Viruses
Pleomorphic Have Spikes Peplomers
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The Negative Strand Enveloped Viruses
Gycoproteins Form Spikes Exist in multimers
(HA1 HA2)3 NA4 Have functions in viral
attachment, and/or fusion, and/or release
antibodies neutralize when bound.