Prsentation PowerPoint

1
Advanced Detection of Bone Quality (ADOQ)   For
a better detection and investigation of
osteoporosis
Osteoporosis Facts and Figures

• A public health issue (WHO figures for the
  European Union, 2001)
• A fracture every 30 seconds
• 20 to 30 of postmenopausal women, 50 of women
  over 60 years old and 13 of men over 50 years
  old
• Second most important public health problem for
  women after breast cancer.
• Induced hospital costs estimated to 23 Billion
  Euros.
• It is shocking that many Europeans at high risk
  of fragility of fractures remain undetected and
  are missing out on preventive therapies with
  proven efficacies. (Mel Read MEP, chair of the
  European Parliament Osteoporosis Interest Group)

Osteoporosis and space During space flights,
astronauts can lose up to 1 of bone mass per
month mainly in the weight-bearing bones. This
remains a major limiting factor for long duration
space flights and the space environment can be
used as a fast and reversible model of
osteoporosis.
Images of bone architecture in the lumbar spine
(local thickness in color code red 14 voxels
200 µm)
Currently, up to 95 of patients suffering a
fragility fracture are discharged without
adequate investigation for osteoporosis.
(Extracted from Osteoporosis in the Community,
Action Plan)
24 year old woman
84 year old woman
ADOQ objectives

• Overall objectives
• To demonstrate the contribution of bone
  structure and bone quality to assess the fracture
  risk and the evolution of osteoporosis
• To show the potential of the analysis of bone
  quality based on 3 Dimensional peripheral
  Computed Tomography (3DpQCT) for a better
  prevention of the risks, for an earlier detection
  and for a better monitoring of bone loss.
• To allow this new technology to be used
  effectively in clinical diagnostic practice and
  to be compared for its potential usefulness
  against the currently used technology (DEXA).

• Five clinical centres (UK, CH, D, F)
• Other objectives
• To collect reference data of 3DpQCT measurements
  on a population aged from 18
• To evaluate the effects of different physical
  exercises on bone architecture as a prevention
  mean in young people
• To assess the effects of decreased physical
  activity on bone structure
• To identify thresholds based on architectural
  and densitometric parameters to better detect
  patients at higher risk of osteoporosis or at
  higher risk of fracture
• To collect reference data on a population
  representative of astronauts and make
  measurements on astronauts pre and post flight to
  assess the potential of the technique to better
  monitor the bone loss of astronauts.

• XtremeCT 3DpQCT developed by SCANCO
• assess both bone density as well as bone
  structure.
• due to the high reproducibility of the system
  as well as the sophisticated evaluation SW, the
  system can even be used to follow structural
  changes.
• In vivo system for human extremities (Radius
  and Tibia)
• Resolution 100 µm

Project ID

• 5th framework programme, Quality of life and
  management of living resources, 6th key action
  The ageing population and disabilities
• Co-funding European Commission, European Space
  Agency, Swiss funding
• Duration 36 months, started on 01/01/2003

Contact (coordinator) Audrey Berthier -
MEDES-IMPS BP4404 - 31405 Toulouse cedex
4 France E-mail audrey.berthier_at_medes.fr Tel
33 (0)5 34 31 96 03 / Fax [phone]