A' DipPen Nanolithography DPN

1
Northwestern University MRSECNovel Developments
in Nanolithography

• A. Dip-Pen Nanolithography (DPN)
• DPN was developed by Chad Mirkin and co-workers1
  to deliver collections of molecules to a
  substrate using an atomic force microscope tip.
• Molecules are deposited via ink chemisorption
  with a resolution of tens of nanometers.
• Applications for DPN include
• - functionalization of nanoscale devices
• patterning protein and DNA onto surfaces
• fabricating conducting polymer nanostructures
• A start-up company, Nanoink, resulted from the
  discovery and development of this novel
  technology.

Fig. 1. Schematic representation of DPN
1. R.D. Piner, J. Zhu, F. Zu, S. Hong, C.A.
Mirkin, Nature 1999, 283, 661.
Fig. 2. Lateral force microscopy of polypyrrole
on a cleaned surface
2
Northwestern University MRSECNovel Developments
in Nanolithography

• B. Multilayer Nanosphere Lithography
• Nanosphere lithography was developed by Richard
• Van Duyne and co-workers1 to allow for
  inexpensive,
• massively parallel nanostructure fabrication that
  is
• flexible in nanoparticle size, shape, and
  spacing.
• Using multilayers of nanospheres, it is possible
  to
• design asymmetric nanoparticles of various
  nanoscale
• sizes and geometries.2
• A novel, robust glucose sensor has been
• developed relying on surface
• enhanced Raman scattering (SERS)
• from the asymmetric nanoparticles
• obtained by this method.3

Fig. 3. AFM image if a period nanoparticle array
of silver resulting from multilayer nanosphere
lithography. Nanoparticles are triangular and
less than 125 nm in dimension.
1. Hulteen, Van Duyne, J. Vac. Sci. Technol.A
1995, 13, 1153. 2. Haynes, Van Duyne, J. Phys.
Chem. B 2001, 105, 5599.3. Shafer-Peltier,
Haynes, Clucksberg, Van Duyne, J. Am. Chem. Soc.
2003, 125, 588.
Fig. 4. left Glucose molecules interacting with
nanoparticles. right SERS Spectrum of A)
Decanethiol, B) Decanethiol Glucose, C)
Spectrum B Spectrum A, D) Crystalline Glucose