Histology for Pathology Male Genital Tract

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Histology for PathologyMale Genital Tract

• Theresa Kristopaitis, MD
• Associate Professor
• Director of Mechanisms of Human Disease
• Kelli A. Hutchens, MD, FCAP
• Assistant Professor
• Assistant Director of Mechanisms of Human Disease
• Loyola Stritch School of Medicine

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Male Reproductive System Histology Objectives

• Describe the pathway for sperm conduction through
  the genital ducts.
• Testis
• On a cross section of testis identify
  seminiferous tubules and interstitial connective
  tissue.
• Name the two types of cells in the seminiferous
  tubules - spermatogenic (germ) and supporting
  (Sertoli cells).
• Explain the function of Sertoli cells.
• On an HE stained section, identify interstitial
  cells of Leydig and explain their function.
• Prostate Gland
• On a section of the prostate, identify prostate
  glands and stroma.
• Identify corpora amylacea (prostatic secretions)
  and explain their significance.
• On a high power view of the prostate describe the
  epithelium that lines the glands.
• Penis
• On a cross section of the penis identify the
  corpora cavernosa, corpora spongiosum, urethra
  and epidermis.

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• Spermatozoa leave the seminiferous tubules via
  the tubuli recti
• From the tubuli recti to the rete testis and
  efferent ductules which lead to the
  extratesticular ducts
• Ductus epididymis
• Ductus / Vas deferens
• Ejaculatory ducts of the prostate
• Urethra

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Seminiferous Tubules

• Consist of germinal epithelium and basement
  membrane
• Epithelium contains various stages of
  spermatogenic cells and supporting cells
  Sertoli Cells
• Sertoli cells provide blood-testis barrier,
  secrete fructose, androgen binding protein,
  anti-Mullerian hormone, inhibin, and activin
• Connective tissue in between tubules contains
  tubuli recti, vessels, and Leydig cells
• Leydig / interstitial cells secrete testosterone

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Seminiferous tubule
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Germinal Epithelium
Sertoli Cell
Leydig cell
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Prostate
Composed of branched tubuloalveolar
glands Lumens often contain prostatic secretions
corpora amylacea
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Corpora amylacea
High power view of gland with its simple columnar
epithelium that is highly folded creating an
irregular lumen.
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Penis
Full cross section image University of Michigan
Medical School Histology website
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urethra
Corpora spongiosum
Corpora Cavernosa
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Corpora Cavernosa of the Penis