???????????18.6 kPa (140mmHg)/12.6kPa(90mmHg) - PowerPoint PPT Presentation

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Title:

???????????18.6 kPa (140mmHg)/12.6kPa(90mmHg)

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Title: 22 Author: USER Last modified by: jb Created Date: 8/26/2003 11:04:48 AM Document presentation format: – PowerPoint PPT presentation

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Title: ???????????18.6 kPa (140mmHg)/12.6kPa(90mmHg)


1
?????
?????
2
  • ???????????18.6 kPa (140mmHg)/12.6kPa(90m
    mHg)
  • ???90
  • ???10
  • ?? ????????, ????, ????, ??, ??, ???,

3
??? ????????
  • ????????????????????? ???,????, a-????
  • ??????????,???
  • ??????????????????,???
  • ?????????????a1 ,????a1 ????ß????a?ß?
  • ??????????????????????
  • ?????????????????????
  • ???,???????
  • ????-??????????,?????????????????

4
(No Transcript)
5
??? ???????
??????????????
??? clonidine (???????)
6
??? ???????
??????????????
????????????,?????,?????????,????????????,????????
?????,??????????,??????????a1????(???a2 gt a1
),???????????,????????????a2???????,??????????????
?,???????????????
??? clonidine (???????)
??
a2?????,
????????
  • ????????????a2??,????????????,????,????,?????
  • ?????????????a2??,???????,????????? NA ??????
  • ?????????a2??,????????,?????????
  • ????????????,?? NA??????????

7
????
????????,??????,?????????????,???????????
????????????????????
????
  • ???????????????
  • ?????????
  • ????? ????,????????????????,?????????????????????
    ???,?????? a????????

???????
8
  • ????
  • ????????????
  • a-????( a-methyldopa)
  • ??????a-????????,??a2??,?????????????
  • ???????,??????????
  • ????????????????????????????????,?????????????????
    ??????

9
????????
???( mecamylunine) ??? ( trimethaphan
camphorsulfonate) ?????????????????,?????
?????????????????????????????????????????????
10
??????????????
??????,???????????????,???????????????????????,???
????,?????????
???(reserpine,???)
????
1.????????????????? l????,23??????,???????34???
?l h???????? 2. ?????????????????,????????????
11
????
???? ????????(??? Mg2-ATP?????????)??,???????????
??????????( MAO)??????????????,? NA??(??)??,
???????????
????
(1)????????,?????????????,????????????,??????,????
??? (2)????????????,?????,????????????,?????
12
????
????????? ? ????????????? ????,?????????,??????
????????? ? ?????????????????????????????????????
?,????????????
13
???(guanethidine)
????
  • ????? ?????????,???????,??????
  • ???? ??????,???????
  • ????????????????????????,? NA???????

14
?????
????????,??24h??,23??????,??????? l
2????????????,?????,????????????????????,????????
??,????????????
???????????????
????
  • ???????? ??????????,?????,?????????????
  • ???????????,40?
  • ????????????????????????

15
????????????
(?)a1????? ???(prazosin, ??? )
16
????????????
(?)a1????? ???(prazosin, ??? )
????
  • ????????
  • ???????????a1??,
  • ?????? a2?????????,???????,????????????????????

????
(1)???????????????? (2)CHF????,??????,???????
?????????????????????????????????????????,??????
????
????
??????????(terazosin)?????(
doxagosin),????( trimagosin)??
17
(?) ß?????
????( propranolol)
???????????,??23????????,?????????????????????,?
?????,???????????????????,????????????
?????????
( l) ???? ß1??,?????,??????,??????,????? (2)
????ß2??,??????,????-?????-???(
RAA)??,????????,?????,????? (3)
????????????ß2??,????????,??NA??? (4)
????????ß??,??????????,?????????????
18
????
  • ?????????,??????????????????
  • ??????????????????????????????????????
  • ?????????,????????
  • ???????????,?????????

??ß??????????????? ????????????????????
19
(?) a? ß?????
  • ????1abetolol(?????)
  • ??a1?ß??,ßgta?
  • ??????,???????????????,??????????,??????????

20
???????
??? hydralazine(????,???)
????
  • ??????????,?????????????
  • ???????????????????? Ca 2???????Ca 2????
  • ???????????,???????????,??????,????????????,??????
    ???????????????,????????????????

21
  • ????
  • ?????,????? ß????????????,???????
  • ????
  • ??,?????????????? ???????????
  • ???????
  • ????????????
  • ???????? ????

22
???sodium nitroprusside (???????)
?????
  • ????????
  • ?????????
  • ?????,???????
  • ?????????
  • ??????????????????????????????,????,??????????????
    ???????,???????????????????

23
?? ????
  • ???????????, ?????Ca2?????, ????????????Ca2?????
    ??????????????????????, ??????????????????????????
    ?????????II?????, ????????????

24
?? ????
????nifedipine(????????)
  • ??????? Ca2??????????
  • ??????????,???????,???????????????
  • ?????????????,????????????
  • ?????????,???????
  • ?ß??????????????????,????????

???? (amlodipine,???) ?????( felodipine) ?????(
nitrendipine)?????( nicardipine)???????
25
?????
????????????????
????( hydrochlorothiazide,?????)
  • ?????? ????
  • ???? ?????
  • ???????,??ß????????
  • ????????????????,??????

26
??????-??????????
RAS ??????????ACE?AT????
??RAS ?????????????? ??RAS ????????????????????
???.
27
ACE?? ??ATI?ATII ?????
BK????? ?????A2, ??????PGs??,
28
AT???
  • ???AII??, ??????????????, ????
  • ????????????, ????????????
  • ??????????, ??????????, ??????, ?????, ????.

29
??????????? ( angiotensin converting enzyme
inhibitor, ACEI)
????
  • ?????ACE, ??AII??, ???????
  • ?????ACE????AII????, ?????AII???
  • ???????????????NE,?????????????, ????ACEI????????

30
  • ??
  • ????(captopril)
  • ????(enalapril)
  • ????(lisinopril)
  • ????(cilazapril)
  • ????(benazepril)
  • ????(delapril)

31
???? ????????????????????
? ????????????????,????????????????????????????
ß????????????? ? ?????????????,
???????????????????, ?????????????????????????????
? ???????????????, ??????????????, ????????????
? ???? A II??????,?????????,?????????,?????????
32
  • ????
  • ????????????,??????,?????????

?????????? ??????? ?AT1????,
??ATII???????????????
33
??? ???????????
1. ????????
  • ???????
  • ????,???????
  • ??????,???????????????
  • ?????,??????????????????????,?????????????
  • ?????,???????????????????????
  • ???????????,?????????,???????????????,??????????

34
??????????,???????,???????????,??,????????????????
?,?????????????????????????,
2.????
  • ????????????
  • ????a-????????????,???????????
  • ??????????????,?????????
  • ???????????????????????
  • ????????????? ß?????(????)?????????????

35
3.?????????
  • ???????????????????
  • ??????????????????????????,??? ß?????????
  • ????????????? ß?????
  • ????????????????????a-?????????
  • ?????????????,?????
  • ???????????????
  • ?????????????? a-????
  • ??????????? ß?????
  • ???????????????????

36
4.???????
  • ?????????????????????????,???????????????,??????
    ???,????????????????
  • ?????????????????????????
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