The Immune System

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• The Immune System

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What is Immunity?
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Immunity

• Immunity
• The ability of the body to fight infection and/or
  foreign invaders by producing antibodies or
  killing infected cells.
• Immune System
• The system in the body responsible for
  maintaining homeostasis by recognizing harmful
  from nonharmful organisms and produces an
  appropriate response.

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Foreign Invaders

• Called Pathogens
• Viruses, bacteria or other living thing that
  causes disease/immune response.
• Antigens
• Toxins that pathogens produce that cause harm to
  an organism.

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Parts of the Immune System

1. Blood - White Blood Cells in particular.
2. Lymph nodes
3. Thymus Gland Produces T Lymphocytes
4. Bone Marrow Produces B Lymphocytes

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How does the body fight infection/foreign
invaders?

• The Bodys THREE lines of Defense
• First Line of Defense The Skin
• Provides Physical and Chemical barriers
• Physical hard to penetrate, made of
  indigestible keratin
• Chemical tears, sweat

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Second Line of Defense Nonspecific Immune
Response

• These are defenses the body uses no matter what
  the invader may be. These defenses include
• Phagocytosis done by Macrophages
• Natural Cell Killers
• Inflammation - caused by release of Histamine
  from leukocytes
• Fever caused by histamines. The fever (high
  temp) kills invaders by denaturing their proteins.

Macrophage A phagocytic cell found in the
liver, spleen, brain and lungs. Travels to all
areas of the body to find and eat pathogens.
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Third Line of Defense Specific Immune Response

• This is a specific response to a specific
  pathogen/antigen.
• The response involves the creation of Antibodies.

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Antibodies

• Y-shaped protein molecule.
• Produced by B-Lymphocytes
• Function Recognize antigens, bind to and
  deactivate them.

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How an antibody operates/works?
Deactivation of a bacterium by an antibody.
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The Pathway of Specific Immune Response
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Cellular Immunity .vs. Antibody Immunity
Cellular Immunity Antibody or Humoral
Immunity

• Carried out by T-Cells
• Infected cells are killed by Cytotoxic T Cells.

• Carried out by B-cells
• Antibodies are produced and dumped into blood
  stream.
• Antibodies bind to antigens and deactivate them.

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Immune Response Explained

1. Antigen infects cells.
2. Macrophage ingests antigen and displays portion
   on its surface.
3. Helper T- Cell recognizes antigen on the surface
   of the macrophage and becomes active.
4. Active Helper T-Cell activates Cytotoxic T-Cells
   and B-Cells.
5. Cytotoxic T-Cells divide into Active Cytotoxic
   T-cells and Memory T Cells.
6. Active Cytotoxic T-Cells kill infected cells.
7. At the same time, B-Cells divide into Plasma
   Cells and Memory B- Cells.
8. Plasma cells produce antibodies that deactivate
   pathogen.
9. Memory T and Memory B cells remain in the body to
   speed up the response if the same antigen
   reappears.
10. Supressor T-Cells stop the immune response when
    all antigens have been destroyed.

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Immune Response Summary
Displays copy of antigen on surface of cell
Antibody Immunity
Cellular Immunity
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Primary .vs. Secondary Immune Response

• Primary Immune Response
• This is a response to an invader the First time
  the invader infects the body.
• No measurable immune response for first few days.
• Next 10 15 days antibody production grows
  steadily
• Secondary Immune Response
• A more rapid response to an invader the 2nd time
  it invades the body.
• Antibody production increases dramatically and in
  a much shorter time period..

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Primary .vs. Secondary Immune Response
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Passive .vs. Active Immunity

• Active Immunity
• This is immunity where the body is actively
  producing antibodies to fight infection.
• Ex You have a throat infection and you are
  actively creating antibodies to fight it.
• Vaccination An injection of a weakened strain
  of an infectious microbe (pathogen) that causes
  the body to undergo active immunity (produce
  antibodies).
• Passive Immunity
• This is immunity where antibodies are given to a
  person from the blood of another person or
  animal.
• This immunity only lasts for a short period of
  time.
• ex Breastfeeding mothers pass antibodies to
  their children through the milk.

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Autoimmune Disease

• Autoimmune diseases are diseases where the immune
  system begins to attack itself.
• Ex
• Rheumatoid Arthritis crippling disease of the
  joints.
• Lupus disease of blood and organs.
• Multiple Sclerosis disease of nervous system
• Cause(s) unknown
• Cures/Treatments No known cures. Usually
  treated with drugs.

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Allergies

• Allergy
• - An exaggerated response by the immune system
  to an allergen.
• Allergen a normally harmless substance that
  causes an allergic reaction.
• ex dust, pollen, mould, food, insect stings
• Types of Allergic reactions
• There are two types of allergic reactions.
• a. Immediate occurs within seconds and
  normally lasts for about 30 mins.
• b. Delayed takes longer to react and can last
  for a much longer time.

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What happens during an allergic reaction?

• During an allergic reaction antibodies cause
  histamines to be released from certain cells.
• Histamines cause
• a. Swelling of tissues
• b. Release of fluids (runny noses and eyes)
• c. muscle spasms (some cases)
• Anaphylaxis or anaphylactic shock
• This is the sudden and severe allergic reaction
  to a substance that can cause death.
• Treatments for Allergies
• Avoidance of material especially food.
• Epinephrine epi pen
• Antihistamines -- benadryl