1
???????????

• ?????????????
• ?????

2
??

• ??????????????????????????????????????????????????
  ??????????????????????,???????????????????????????
  ?

3
??

• ?????????????????????, ????????????????????,??????
  ?????????,?????????????????????

4
?????????????(7-15???)
5
?????????

• ??????????????????????????(??1998?2002?)??????????
  ???????????????2007???????????????????????????????
  ??20.34?????
• ??2002?2003???????????????????????????????????????
  
• ????????2002???????????????????????,??2002????,???
  ?????????????????????????????????

6
????????

• ????????????????(minimum persistent
  inflammation)???????????,???????????????????,????
  ????????????????????,?????????????????,???????????
  ????

7
Allergy or oral tolerance ?????? TH1-TH2
???Jenmalm M.C., Björkstén B. - PAI 9 (11)
5-12 (1998) and many others
Immune responses to allergens, pathogens, etc
IF-?, - ? LPSendotoxines TGF-?
IL-4, IL-5 PGE 2
TH 0
TH-r
TH 1
TH 2
TH 3
IL-10TGF- ?

• Type I diseases
• Defense against infections
• Oral tolerance
• However Autoimmune
• diseases
• Typ I diabetes
• IBD Crohns disease
• Multiple Sclerosis

• Type II diseases
• IgE synthesis and therewith
• Allergies
• Defense of parasites
• However also
• Artherosclerosis
• Reumatoid athritis

8
????????????T??

• ??????????T??(Th2)?????????,???T?????????????????
  ??
• ???????Th2????
• ????? ???????????T??(Th1)??
• ????? ????Th2??

9
Annals of Allergy, Asthma, Immunology 1999
83426-430.
10
Development of Immune Function in The Newborn
Infant