Leukocytes

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Leukocytes

• Leukopenia
• Leukocytosis

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Leukopenia(Agranulocytosis)

• Myeloid stem cell suppression
• Ineffective granulopoisis
• Heriditary disorders, kostmann syn.
• Immune destruction
• Spleenic sequestration
• Peripheral destruction

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Leukocytosis
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Normal Lymph node
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Lymphadenitis

• Acute nonspecific lym.
• Chronic non specific lym.
• Follicular hyperplasia
• Sinus histiocytosis
• Paracortical hyperplasis

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Neoplastic proliferation of leukocytes

• Lymphomas
• Leukemias
• Plasmacell dyskerasia
• Langerhans cell histiocytosis

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Lymphoproliferative disorders

• Lymphomas
• Leukemias
• Plasma cell dyscrasia

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Myeloid Neoplasms

• Acute Leukemias
• Chronic Leukemias
• Myelodysplastic disorders
• Myeloproliferative disorders

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Lymphomas

• Hodgkins lymphoma (HD)
• Non Hodgkins lymphoma (NHL)

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Hodgkin's Lymphoma
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Non Hodgkin's lymphoma
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LeukemiaClassification

• Acute Aml , ALL
• Chronic CML , CLL

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Myeloblast Lymphoblast

• Chromatin Fine Clamp
• Nucleoli 3 5 1- 2
• Granules Variable Non
• PA -
  
• Tdt 5
  95
• Sudan Black -
• Mpo -

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A.M.L
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A.L.L
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Myelo dysplastic syndromes

• Refractory anemia
• R.A with ring sideroblast
• R.A with excess blast
• Chronic myelomonocytic leukemia
• RAED in trans Formation
• CMML in trans Formation

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Chronic myeloproliferative disorders

• CML
• P.V
• MMM disease
• E.T

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Chronic lymphoproliferative disorders

• CLL
• PLL
• NHL
• HCL

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Plasma Cell neoplasms

• Multiple myeloma
• Solitary plasmacytoma
• Waldenstorm macroglobulinemia
• Heavy chain diseases
• Primary Amiloidosis
• Monoclonal Gamma pathy U.S

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HistiocytosesLangerhans H / HistiocytosisX

• Eosinophilic granuloma
• Acute disseminated H.
• ((Letterer Siwe synd))
• Hand schuller chrisrian disease

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Morphologic aspects

• HLA DR
• CDa
• Birbeck (HX) granules

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