Physiology of leukocytes. Immunity

1
Physiology of leukocytes. Immunity
2
Function of leukocytes

• 1. Protective
• 2. Transport
• 3. Metabolic
• 4. Regenerator

3
Quantity of leukocytes and their changes

• White cells are nucleated and somewhat variable
  in size and shape. Their numbering is 4-9Giga
  per liter. The number of lymphocytes are 18-37
  ,
• monocytes 3-11 ,
• eosinophils 0,5-5 ,
• basophils 0-1 ,
• juvenile neutrophile 0-1 ,
• relating to stab (rod-shaped) neutrophil 1-6 ,
  
• segmented neutrophil 47-72 .
• The number of leukocytes may increase or
  decrease.

4
Development of monocytes

• common progenitor cell
• uncommited stem cell
• commited stem cell
• monoblast
• promonocyte
• monocyte
• tissue macrophage.

5
(No Transcript)
6
(No Transcript)
7
Development of lymphocytes

• common progenitor cell
• bone marrow lymphocytes precursor
• lymphoblast
• prolymphocyte
• large lymphocyte
• small lymphocyte.
• Lymphocytes in the fetus are thought to arise
  first in the thymus. Later they are found in
  lymph nodes, spleen, and other lymphoid tissues
  as well as in bone marrow.

8
Development of gtanulocytes

• common progenitor cell
• uncommited stem cell
• commited stem cell
• myeloblast (basophil, neutrophil, eosinophil)
  promyelocyte
• myelocyte
• metamyelocyte
• juvenile
• rod-shaped neutrophil (basophil, eosinophil),
• segmented neutrophil, basophil, eosinophil.

9
(No Transcript)
10
Physiological role of T-lymphocytes

• 1. Immune memory.
• 2. Anti viruses immunity.
• 3. Anti tissue immunity.
• 4. Regulate phagocytosis.
• Function of ?-lymphocytes
• 1. Immune memory.
• 2. Specific immunity. B-lymphocytes syntheses the
  immunoglobulins such as IgM, IgN, IgA, IgG, IgB,
  IgE.

11
(No Transcript)
12
System of mononucleares phagocytes

• These is the system, which common the cells with
  one nucleus,
• common origin from red bone marrow, common
  function of high specific phagocytosis

13
(No Transcript)
14
(No Transcript)
15
(No Transcript)
16
The index of nuclears changing of neutrophyls,
it interpretation

• NCN(MJS1)/S2, where
• M myelocytes,
• J juvenile,
• S1 stab neutrophils,
• S2 segmented neutrophils
• Norm is 0,06-0,09

17
Thank you!