Resveratrolo

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Resveratrolo
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Antiestrogens can stop harmful effects of estrogen
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Ligand Induces a Conformational Change in the
LBD that Repositions helix 12
No Ligand
Agonist
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NR Antagonists Alter the Position of Helix 12
Agonist (ER)
Antagonist (ER)
No Ligand
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SERMs
(Selective Estrogen Receptor Modulators)
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PHENOL

• gt100,000 Compounds
• classified according to basic skeletal structure
• acidic
• Participates in oxidation-reduction reactions

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Polyphenol content
Total polyphenols
Red grape, ave. 5500 mg/kg
Red wine 7004000 mg/L
White grape, ave. 4000 mg/kg
White wine 150-400 mg/L
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Vascular benefits Quercetin, catechin,
resveratrol

• Inhibition of platelet aggregation
• Inhibition of LDL oxidation (plaque)
• Vasodilation
• Inhibition of vasoconstriction (tannins)

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Anti-carcinogenic properties

• Stilbenes inhibit cell proliferation
• Association with decreased colon cancer
• Inhibition of non-melanoma skin cancer
  -resveratrol
• Estrogenic effect-resveratrol /-

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Resveratrolo