HongWen Deng, Ph'D'

1
???????????(part 2)

• Hong-Wen Deng, Ph.D.
• Osteoporosis Research Center
• Creighton University, Omaha, NE, USA
• ??? violet39 (DXY)

2
??????(1a)
3
??????(1b)
4
595????????(Koller et al. 2000) ???630??53???(Deng
et al. 2002)????(power)??

B???0.05
A???0
5
??????(2)
6
??????(3)
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??????(4)
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??????(5)
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????????(power)????80(?LOD?3.0?)
??
10
??QTL??
11
??????????????? ????QTL??
12
??????????????? ????QTL??
13
??????????????? ????QTL??
14
??????????????? ????QTL??
15
????(30cM?1cM)(Deng et al., 2000)????(Deng et
al., 2001)
16
???????

17
????????????

18
????????????(1)

• ??????????(NIDDM)(Ghosh et al. 2000)???20,11,2,10
  ?6
• ????(Watanabe et al. 2000) ???3(??C-?/???),???10(
  ???????),???13(?????2-h???),???17?19(?????????)?

19
????????????(2)

• ????(Broeckel et al., 2002)???14?
• ????(Broeckel et al., 2002)???1?6(???A),???14,17(
  ???????????),???1(???????????),???9(??????),???6(?
  -????),???6(??????),???1(??????)?

20
DNA?????
21
DNA???????

• ???????????????,?????????9?????EST?? (Vaes et
  al., 2002)?

22
???????

• 30,000??,150???
• ????????(??????????,??????-??????)
• ????????????????????????

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??
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