PHYSIOLOGY OF THE PANCREAS

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PHYSIOLOGY OF THE PANCREAS
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Actions of Insulin on the Liver

• Stimulates glucose uptake
• Stimulates glycogenesis
• Stimulates glycolysis
• Stimulates HMP shunt activity
• Inhibits glycogenolysis
• Inhibits gluconeogenesis
• Stimulates lipogenesis
• Inhibits lipolysis
• Stimulates cholesterol synthesis
• Increases VLD lipoprotein
• Increases potassium and phosphate uptake

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Actions of Insulin on Muscle

• Stimulates glucose uptake
• Stimulates glycogenesis
• Stimulates glycolysis
• Inhibits glycogenolysis
• Inhibits FFA uptake and oxidation
• Stimulates proteogenesis
• Inhibits proteolysis
• Stimulates uptake of potassium, phosphate and
  magnesium
• Increases blood flow

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Action of Insulin on Adipose Tissue

• Stimulates glucose uptake
• Stimulates glycolysis
• Stimulates lipogenesis
• Inhibits lipolysis and ketogenesis

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Actions of Glucagon on the Liver

• Stimulates glycogenolysis
• Stimulates gluconeogenesis
• Inhibits glycolysis
• Stimulates lipolysis and ketogenesis