Thymidylate PowerPoint PPT Presentations

Difficult to gain selectivity between enzymes using the same cofactor ... Possibility of better selectivity between different targets. De Novo Design. Notes ...

95 % of cervical cancers contain detectable HPV DNA ... GST/HPV L1 fusion protein. Produced in tobacco plants. Simple extraction and purification process ...

cells have a requirement for the synthesis of new DNA. ... Thymidylate synthase and dihydrofolate reductase, enzymes critical for ...

Chapter 26 Synthesis and Degradation of Nucleotides Synthesis of dTMP from dUMP is catalyzed by thymidylate synthase. This enzyme methylates dUMP at the 5-position to ...

Thymidylate synthase oxidizes N5,N10-methylenetetrahydrofolate to ... Fish and most terrestrial mammals oxidize uric acid further before excreting the ...

9. AICAR transformylase. 10. IMP synthase. Glu, PPi. Gln. PRPP ... (AICAR) (FAICAR) Trifunctional enzyme. Potent inhibitors of purine nucleotide synthesis ...

Nucleic Acid Metabolism Nucleotides Essential for all cells Carriers of activated intermediates in carbohydrate, lipids and proteins CoA FAD NAD NADP

(Use in alzheimer disease, glaucoma) ... Statins inhibit this enzyme, ... Clinical Enzymology Author: Haiza Last modified by:

... Dihydrofolate reductase ...

Title: Author: CS907 Last modified by: Jamie Created Date: 11/24/1999 2:01:16 AM Document presentation format: (4:3)

SAR Antidiabetic Agents X = O, S, or N

Title: Lecture 7-Enzyme Inhibition-Drug Discovery Meisenberg and Simmons pp: 48-51 Author: Suriender Kumar Last modified by: suriender kumar Created Date

Asparate Ribose 5-phosphate PRPP Phosphoribosyl amine IMP ... Nucleotidases Nucleoside phosphorylases Deaminases Xanthine oxidases 3. the final common ...

Pyrimidine synthesis

Isotropic temperature factors correct for the fact that atoms in ... in coot) ... (show protein in coot) The figure at rights shows. which segments move when ...

Synthesis and catabolism of nucleotides

26. Deoxyribonucleotide biosynthesis and nucleotide catabolism; drug design and testing ... Enzymes of nucleotide biosynthesis provide targets for cancer ...

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Enzymology

Colonoscopy in 1 y, repeat in 1 y if. abnormal or at least every 2-3 y if. negative for polyps. ... colonoscopy due to obstructing lesion, colonoscopy in 3-6 ...

Amino acids are glucogenic, ketogenic, or both. Table 15.2 ... Aromatic amino acids: glucogenic (alanine or fumarate) and ketogenic amino acids (acetoacetate) ...

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Finish up Tuesday's Leftovers. Brief Explanation of how dUMP is converted to dTMP. Some clinically relevant treatments based on these pathways that are used to combat: ...

PHARMACOLOGY PROJECT ANTIVIRAL & ANTIFUNGAL DRUGS Ppt by by: Dr gauri verma Dr. Prashant MD. phrmacology4students.com drprashantw@gmail.com Names of fungi ...

Supplies ribose for. nucleotide metabolism (to make nucleotides, NOT. to produce energy) ... Activated ribose (PRPP) base. Nucleotides. De Novo Pathway ...

About OMICS Group OMICS Group International is an amalgamation of Open Access publications and worldwide international science conferences and events.

Bio-informatique Structurale au Centre de Biochimie Structurale (Montpellier) http://www.cbs.cnrs.fr 22 Octobre 2003 Edition et Visualisation : ViTO.

Any slowing of DNA production marrow failure. MEGALOBLASTIC ANEMIA ... to be avoided unless hemodynamic compromise is present, or patient having angina ...

Title: PowerPoint Presentation Last modified by: Dokuz Eyl l niversitesi Created Date: 1/1/1601 12:00:00 AM Document presentation format: Ekran G sterisi

Biological and Molecular Targeted Therapy for HHC Sheng-Long Ye, MD, PhD Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai, China

To ribose phosphate. Precursors are Glutamine (NH2), Bicarbonate (C) ... Common side effects of DNA inhibitor chemotherapeutics: Gastrointestinal disturbances ...

The Organic Chemistry of Drug Design and Drug Action Chapter 5 Enzyme Inhibition and Inactivation Enzyme Inhibition and Inactivation Categories of Enzyme Inhibitors ...

Folic Acid. HMDB00121. ONE CARBON POOL BY FOLATE. In Homo sapiens ... 5,10- methenyl THF. HMDB01354. Phosphoribosylglycinamide. formyltransferase. A8KA32 ...

Irreversible inhibitors bind at the active site of the enzyme and form a ... Doxycycline. competitive inhibitor of collagenase- control of periodontal disease ...

Title: Sulfonamides,Trimethoprim and Quinolones Last modified by: Sushike Created Date: 5/26/2003 11:39:43 PM Document presentation format ...

Pharmacology of Chemotherapy David W. Hedley MD Dept Medical Oncology and Hematology Division of Applied Molecular Oncology Chemotherapy Cytotoxic agents - generally ...

Anti-Viral Therapies. HIV- Human Immunodeficiency Virus. HSV- Herpesvirus ... Acyclovir as an Anti-HSV Agent. Acyclovar (acycloguanosine)- purine analog ...

anticancer agent and recent advances

Title: PowerPoint Presentation Author: Marc Tischler Last modified by: shahnaz_khaghani Created Date: 12/5/2002 11:36:09 PM Document presentation format

Watson & Crick elucidated DNA structure based on X-ray diffraction studies ... DNA Structure. Sugar-phosphate backbone. Pairing between complimentary N-bases ...

information about blood and anticoagulant drugs.

Inhibit pyrimidine de novo synthesis. Inhibits phosphoribosylamine formation ... De novo synthesis. Incorporated into RNA/DNA termination ...

Marine chemistry (corals, bacteria, fish etc) Chemical synthesis (traditional) ... mass spectrum infra red ultra violet nmr (1H, 13C, 2D) X-ray crystallography ...

Title: PowerPoint Presentation Author: agrippo Last modified by: Srinivas Created Date: 2/13/2006 5:07:38 PM Document presentation format: On-screen Show (4:3)

From there, it recurs in the genital area. ... Diseases include cold sores, genital herpes, chickenpox, shingles, mononucleosis, etc. ...

Classification of antifungal drugs: Can be classify to six groups. 1- Antibiotics [ Amphotricin B,(AMB), Nystatin, Greiofulvin] 2- Antimetabolities [ 5- Flucytosine,(5-FC), inhibition nucleic acid synthesis] 3- Azoles: a-Imidazoles: Bifonazole, Clotrimazole, Econazole, Ketoconazole, Miconazol. b- Triazoles: Fluconazole, Itraconazole, Voriconazole Inhibition of ergosterol synthesis. 4- Allylamine [Terbinafine, Naftifine ] Inhibition of Lanosterol and Ergosterol synthesis. 5- Echinocandins Inhibit fungal cell wall biosynthesis 6- Miscellaneous Antifungals [Tolnaftant, Undecylenic acid, Benzoic acid, Ciclopirox olamine.]

All you need to know about Chemotherapy. Lynne Cormode What is Chemotherapy? Systemic treatment against malignant cells to try and prevent growth, invasion ...

It is the science dealing with the development of congenital malformations. A teratogen ( terat = monster or ugly animal): It is a substance that alters embryonic or ...

Chapter 8 Manipulating Proteins, DNA, and RNA

Title: No Slide Title Author: Michael Terns Last modified by: Mike Terns Created Date: 11/23/1998 8:19:44 PM Document presentation format: On-screen Show (4:3)

In fungi: ergosterol in membranes: higher affinity than. mammalian ... Impair synthesis of ergosterol; inhibit sterol 14 a-demethylase (of cyt. P450) ...

Lecture 6: Computer aided drug design: structure-based approach. Chen Yu Zong Department of Computational Science National University of Singapore

'A surgeon who uses the wrong side of the scalpel cuts his own fingers and ... Proband ( /-) An anecdote-how interesting!? 524 stage IV patients. IFL: Irinotecan ...

LEA-3D, FlexX, ViTO, Fitter. meta-server. RESCUE, Fireman. From molecular ... V. Catherinot (CDD INSERM) FITTER,ViTO. L. Chiche (DR CNRS) SFE, Knottins ...

Used to treat intestinal helminth infections, especially those caused by nematodes and cestodes ... used in China for over 200 years to treat fever and chills ...