Metabolism of nucleotides - PowerPoint PPT Presentation

About This Presentation
Title:

Metabolism of nucleotides

Description:

Synthesis and catabolism of nucleotides – PowerPoint PPT presentation

Number of Views:106

less

Transcript and Presenter's Notes

Title: Metabolism of nucleotides


1
Metabolism of Nucleotides
R. C. Gupta Department of Biochemistry National
Institute of Medical Sciences Jaipur, India
2
E M B - R C G
3
E M B - R C G
4
Digestion
E M B - R C G
5
E M B - R C G
6
E M B - R C G
7
Synthesis of nucleotides
E M B - R C G
8
(No Transcript)
9
E M B - R C G
10
De novo synthesis of purine nucleotides
E M B - R C G
11
E M B - R C G
12
E M B - R C G
13
E M B - R C G
14
(No Transcript)
15
E M B - R C G
16
(No Transcript)
17
(No Transcript)
18
(No Transcript)
19
(No Transcript)
20
(No Transcript)
21
(No Transcript)
22
Formation of ATP and GTP
E M B - R C G
23
(No Transcript)
24
Regulation of de novo synthesis
E M B - R C G
25
E M B - R C G
26
PRPP glutamyl amidotransferase catalyses the
first reaction unique to purine nucleotide
synthesis
E M B - R C G
This is the main regulatory enzyme
It is allosterically inhibited by GMP
27
E M B - R C G
28
E M B - R C G
29
Synthesis of purine nucleotides by salvage
pathway
  • Pre-existing purine bases and nucleosides may be
    salvaged to form new nucleotides
  • Conversion of purine bases into nucleotides is
    catalysed by two enzymes

Adenine phosphoribosyl transferase (APRT)
Hypoxanthine-guanine phosphoribosyl
transferase (HGPRT)
30
E M B - R C G
31
(No Transcript)
32
E M B - R C G
33
(No Transcript)
34
Regulation of salvage pathway
E M B - R C G
35
Catabolism of purines
E M B - R C G
36
E M B - R C G
37
NH2
N
Adenosine
Purine nucleoside phosphorylase
N
deaminase
H2O
NH3
Pi
Ribose-1-P
6
N
N

Ribose
R C G
Adenosine
Inosine
Hypoxanthine
Xanthine oxidase
Xanthine oxidase
H2O2
H2O2
O2 H2O
O2 H2O
Xanthine
Uric acid
38
Guanine
R C G
Guanosine
H2O
Guanase
NH3
Xanthine oxidase
H2O2
O2 H2O
Xanthine
Uric acid
39
E M B - R C G
40
E M B - R C G
41
E M B - R C G
42
De novo synthesis of pyrimidine nucleotides
E M B - R C G
43
E M B - R C G
44
E M B - R C G
45
(No Transcript)
46
Second reaction
Aspartate transcarbamoylase
E M B - R C G
Pi
Carbamoyl phosphate
Carbamoyl aspartate
Aspartate
Carbamoyl group transferred to aspartate
47
(No Transcript)
48
Fourth reaction
E M B - R C G
Dihydro-orotate
Orotate
Dihydro-orotate oxidized to orotate
49
(No Transcript)
50
(No Transcript)
51
E M B - R C G
52
E M B - R C G
53
(No Transcript)
54
Thymidylate
E M B - R C G
55
E M B - R C G
56
E M B - R C G
57
(No Transcript)
58
E M B - R C G
59
Regulation of de novo synthesis
E M B - R C G
60

E M B - R C G
61
Synthesis of pyrimidine nucleotides by salvage
pathway
E M B - R C G
62
E M B - R C G
63
(No Transcript)
64
(No Transcript)
65
Formation of deoxyribonucleotides
E M B - R C G
66
E M B - R C G
67
E M B - R C G
68
E M B - R C G
69
(No Transcript)
70
E M B - R C G
71
Catabolism of pyrimidines
E M B - R C G
72
(No Transcript)
73
E M B - R C G
74
(No Transcript)
75
Thank you
Write a Comment
User Comments (0)
About PowerShow.com