Cell-to-Cell Signaling

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Cell-to-Cell Signaling

• By Kristen Campbell
• 21 November 2002

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Goals

• Definition of Cell Signaling
• Why is it important
• Brief Discussion of the process
• Signaling Types

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What is Cell Signaling?

• Cell-Cell Communication
• Mediated by Signals
• Signaling Types
• Contact Signaling
• Long Range Signaling
• Short Range Remote Signaling

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Why is Cell Signaling Important ?

• For Development of a Multicellular Organism you
  must have
• Regulation of Growth
• Organization of tissues
• Coordination of Function

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Communication Involves 6 Steps

• Synthesis of a Signaling Molecule
• Release of the Signaling Molecule
• Transport of the Signal to Target Cell
• Detection by Specific Receptor Protein
• Change in Cellular Function or Development
• Removal of Signal

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Types of Signaling

• Contact Signaling
• Long Range Signaling
• Short Range Remote Signaling

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Contact Signaling

• Tight Junctions
• Desmosomes
• Gap Junctions

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Tight Junctions
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Desmosomes
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Gap Junctions
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Distant Signaling

• Endocrine Signaling
• Paracrine Signaling
• Autocrine Signaling
• Signaling by Plasma Membrane Proteins

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Endocrine Signaling
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Paracrine Signaling
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Autocrine Signaling
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Signaling by Membrane Proteins
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Summary

• Definition of Cell Signaling
• Why Cell Signaling is Important
• Steps involved in Cell Signaling
• Types of Cell Signaling

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Discussion