Semantic Web

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Semantic Web Medicine

• F????? ?a???????
• ???st??a? ???????
• ?at??p????? ??sta?

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??sa???? (1/4)

• ? a??pt??? t?? p????f???a??? ?a?
  t??ep????????a??? s?st?µ?t??
• ?fe?a? st? p??s????? ????? ?p??
• ?at???? p????f?????
• ??e?t??????? f??e??? ??e?a?
• t??e?at????
• ?at????? ß?se?? ded?µ????
• ??sa???? ?at????? ?????????

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??sa???? (2/4)

• St?? ???? t?? ?at????? ta te?e?ta?a ?????a ??e?
  ???e? s?µa?t???
• e?e???t??? p??sp??e?a µe st???
• s?????e?s? ?a? s?????t??s? t?? ?at?????
  p????f???a? se
• µe???e? d?as??dedeµ??e? ß?se?? ded?µ????
• ?µ??e???p???s? t?? ?at????? ???????a? se
  ??sa?????
• ap????e?s? ?at????? ded?µ???? t?? as?e???, µe t??
  µ??f?
• t?? at?µ????, ??e?t??????? ?a? ?ata?eµ?µ????
  fa????? ??e?a?
• ap?µa???sµ??? pa?a???????s? t?? p??e?a? t??
  ??e?a? t??
• as?e??? µ?s? t?? d?ad??t???
• a???t?s? ?at????? e?????? µe ß?s? t? pe??e??µe??
  t???

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??sa???? (3/4)

• St?? pe??ss?te?e? ap? t?? s??????e? ?at?????
  efa?µ???? ? ?????
• p?? d?ad?aµat??e? ? ap?te?esµat??? e????? ?a?
  ??????? d?a????s?
• ?a? a???t?s? p????f???a?, e??a? p??? ßas????.
• G?a t?? ???? a?t? ? p????f???a ?a p??pe? ?a e??a?
  ???a??µ???
• ?a? ?e?a???µ??? µe t??p? p?? ?a ?a??st? e?????
  t?? ?ata???s?
• t?? ap? t?? ?????p? ?a? ??????? t?? epe?e??as?a
  t?? ap? t??
• ?p?????st?.

S?µas????????? ?st??
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??sa???? (4/4)

• ???ß??µata t?? WWW

• S?µas????????? ?st??

?? a?a??t?se?? st? WWW e?et????? µ??? t? 20 t??
s?et???? ?st?se??d?? ?a? ep?st??f??? µe????
p?s?t?ta ?s?et?? p????f???a?
??p?as???eta? se µ??e??? ???e 6 µ??e?
? p????f???a st? d?ad??t?? e??a? ?a????sµ??? ?a?
s??dedeµ??? ?ts? ?ste ?a µp??e? ?a ???s?µ?p????e?
ap? t??? ?p?????st?? ??a t?? a?t?µat?p???s?, t??
e?s?µ?t?s? ?a? t?? epa?a???s?µ?p???s? ded?µ????
se p????? efa?µ????
? p????f???e? st? www de? µp????? e????a ?a
epe?e??ast??? ap? software agents
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S?µas????????? ?st?? ?a? ?at????

• National Library of Medicine (NLM)
• MeSH ??t?????a ?at????? ????
• MEDLINE ß?ß?????af??? ß?s? ded?µ????
• PubMed µ??a?? a?a??t?s??
• UMLS Unified Medical Language System
• The Visible Human Project
• MELISA MEdical Literature Search Agent
• ?pt???p???s? ?at????? p????f????? µe ???s?
  s?µas????????? µetaded?µ????
• ??t?????a ?at????? sfa?µ?t??
• ??t?????a as?e???? st?? ?at???? f??e??
• ???e? p??sp??e?e?

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? National Library of Medicine (NLM) e??a? ?
µe?a??te?? pa???sµ??? ?at???? ß?ß??????? ?a?
ed?e?e? st? National Institutes of Health st??
Bethesda t?? Maryland.
http//www.nlm.nih.gov
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• ? NLM pa???e?
• ?????f???e? ??e?a?
• MEDLINE/PubMed, MEDLINEplus, NLM Gateway
• ?p??es?e? ß?ß????????
• ?at??????, ??se?? ?ed?µ????, MeSH, ?st??????
  p????f???e?, ??µ?s?e?se??
• ??e???t??? p?????µµata
• Computational Molecular Biology, UMLS, Medical
  Informatics, Visible Human Project

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• ? MEDLINE e??a? ? p??t? ?a? p?? ???st?
  ß?ß?????af??? ß?s?
• ?at????? ded?µ????.
• ?a???e? p????f???s? se ??µata ?at?????,
  ??s??e?t????,
• ?d??t?at?????, ?t???at????? ?a? ??a t? s?st?µa
  pe???a???? ?a? ??e?a?.
• ?e????e? ß?ß?????af???? e???af?? ?a? pe?????e??
  ap? pe??p??
• 3.900 t?????ta ß???at???? pe???d??? p??
  e?d?d??ta? st?? ???µ??e? ????te?e? t?? ?µe?????
  ?a? se 70 ???e? ???e?.
• ???s?µ?p??e? t?? ?at???? ??t?????a MeSH

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• ???a? µ?a s?????? µetaded?µ???? ß???at?????
  p????f???a?
• ????afa
• pe????af??? ?a? s?µas???????? µetaded?µ??a

PMID Pubmed Identifier PT Publication Type
UID Unique Identifier DA Date of Acceptance
TI TItle DP Date of Publication
AU Author AB ABstract
LA LAnguage SO Source of Publication
MH MeSH term related (s?µas???????? µetaded?µ??a) MH MeSH term related (s?µas???????? µetaded?µ??a)
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• ? p??sßas? st? MEDLINE ???eta? µ?s? t??
• µ??a??? a?a??t?s?? PubMed.

http//www.ncbi.nlm.nih.gov/entrez/query.fcgi
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• ?? s?st?µa a?a??t?s?? PubMed a?apt?????e ap? t?
  National Center for Biotechnology Information
  (NCBI) se s??e??as?a µe e?d?te? ß???at?????
  ß?ß?????af?a?.
• ???a? ??a e??a?e?? a?a??t?s?? ß?ß?????af????
  pa?ap?µp?? ?a? ep?p???? ???s?µ?p??e?ta? ??
  s??desµ?? ??a t?t???? pe???d???? t?? e?d?t?? p??
  s?µµet?????.
• ?? e?d?te? p??µ??e???? st?? NLM ß?ß?????af????
  e???af??, ? ?p??a µet? t?? p??s??te? st? s?st?µa
  a?a??t?s?? PubMed.

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To PubMed ep?t??pe? d?af??et????? t?p???
a?a??t?s?? ??a ??a Keyword ???s?µ?p????ta?
pe?????sµ??? p?? ???µ????ta? Search modifiers
MAJR Mesh term as major topic
MHNOEXP Mesh term without searching the descendants
MH Like previous expanding the search through descendants
TI The term in the Title
TW The same, plus looking the term in the Abstract
PT This term as Publication Type
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• ?? MeSH (Medical Subject Headings) e??a? ?
  ??sa???? ?????????
• p?? ??e? a?apt??e? ? NLM.
• ?? ???????e? t?? MeSH e??a? ap????e?µ??e? se
  a?faß?t??? se??? a???
• ?a? se p???a????sµ??? ?e?a????? d?µ?.
• St? p?? ?e???? ep?ped? t?? ?e?a?????? d?µ??
  ?p?????? ?????e? ?p??
• ??at?µ?a ? ??????? ??ata?a???, e?? se
  e?d???te?a ep?peda
• ?p?????? ?????e? ?p?? ?st???a???, ??taµ??? C.
• ?p?????? 21.973 ???? sto MeSH.

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• ? ??sa???? MeSH ???s?µ?p??e?ta? ap? t?? NLM
  ??a indexing
• ??????.
• ?a ????a a?t? p???????ta? ap? ta 4.600 ????fa?a
  ß???at???? pe???d???
• ?a? ???s?µ?p?????ta? st? ß?s? MEDLINE.
• ?p?p???? t? MeSH ???s?µ?p??e?ta? se p????? ß?se??
  t?? NLM p??
• pe??????? ?ata?????? ß?ß???? ?a? a??e???.

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• ? ?d??? ???? eµfa???eta? se p???ap?? ??ad?? t??
  ?e?a??????
• p???d??d???

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• ???e ???? pe?????feta? ap? t?? pa?a??t? ?d??t?te?

Name Name of the term
Definition Medical Definition
Related Terms Other related terms
Subheadings Allowed Subheadings to modify and complement the meaning of this term
Position on the polytree Fathers and sons on all locations of the term
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• Unified Medical Language System
• ??e??????e? t?? a???t?s? p?????? p????f???a? ?
  ?p??a
• p?????eta? ap? ?ata?eµ?µ??e? p???? ?p??
  ß???at????
• ß?ß?????af?a, ?at?????? fa?????? ??e?a?, ß?se??
  ???s?? ?a?
• ?ata?????? ??a ?at?????? ???a??sµ???.

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• ????te?t????? ??e?? p???? ???s??
• The Metathesaurus ?e????e? s?µas????????
  p????f???a ??a ß???at????? ?????e?, ???µata ?a?
  s?s?et?se?? µeta?? t???.
• The Semantic Network ?p?te?e? ??a d??t??
  ?e????? ?at??????? ?a? s?µas????????? t?p?? ??a
  ????? t??? ????? t?? Metathesaurus.
• The Specialist Lexicon ?e????e? s??ta?t???
  p????f???a ??a ß???at?????? ?????.

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• Entity
• Physical Object
• Substance
• Chemical
• Chemical Viewed Structurally
• Organic Chemical
• Lipid
• Steroid

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• ?e t?? a??pt??? s???????? µe??d?? t??sd??stat??
• ?pt???p???s?? e??a? d??at? ? 3D a?apa??stas? t??
  a?at?µ????
• d?µ?? t?? a????p???? s?µat??.
• ?p???d?p?te ?p?s????? ap? ta 3D a?t??e?µe?a
  µp??e? ?a
• a?apa?asta?e? e?te µ??? t?? e?te ?? µ???? µ?a?
  µe?a??te???
• ?µ?da?.

??µ?????e?ta? ? a????? ??a ??a e??a?e?? p?? ?a
d?e??????e? t?? p??sßas? sta 3D a?t??e?µe?a.
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• ??µ?????????e ??a s?st?µa p?????s?? se 3D e????e?
  
• a?at?µ?a?. ??t?? s?s?et????ta? µe ?????e?
  a?at?µ?a? t??
• ?p??e? s??d?e? µ?a s?µas???????? ??t?????a.

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??????a µe t? µ???? t?? s?µat?? p?? ape??????e? ?
3D e????a, pa???s???eta? t? a?t?st???? tµ?µa t??
??t?????a?

• ? ?e???? ?a? ??e? ?? ?p????pe? ?at?????e?
  ?st?? e??a? IsA t?? ?e????te??? ???s?? BONES
• ta ?st? COCCYX, OS COXAE, SACRUM e??a? IsA t??
  ???s?? BONES PELVIS

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Medical Literature Search Agent (1/3) (MELISA)

• ????t??a? a???t?s?? ?at????? p????f?????
  ßas?sµ???? st??
• ?at???? ??t?????a

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Medical Literature Search Agent (2/3) (MELISA)
???s?µ?p??e? t?? ?at???? ??t?????a t?? MeSH
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Medical Literature Search Agent (3/3) (MELISA)
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?pt???p???s? ?at????? p????f?????

• ???s? t?? ?e?a???a? t?? p???d??d??? t?? ?esh
• ???s? t?? s?µas????????? µetaded?µ???? t?? Mesh
• ?µf???s? t?? p?????? t?? s?et???? µe ???e ???
  ??????
• Ta µp????se ?a ?pt???p????e? µe ???s? 3D d??d??
• SIMS 247 Project, Berkley

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?pt???p???s? ?at????? p????f?????
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?pt???p???s? ?at????? p????f?????
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??t?????a ?at????? sfa?µ?t?? (1/2)

• ?at???? sf??µata
• s????
• ep?ß?aß?
• µp????? ?a ap?fe??????
• S?????? ?fe????ta? se
• ???e??? p????f???a?
• p??ß??µata st?? ep????????a

??µ?????e?ta? ? a????? µ?a? ??t?????a? p?? ?a
s?s?et??e? ta ?at???? ????, t?? ???e???
p????f???a? ?a? t?? ep????????a
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??t?????a ?at????? sfa?µ?t?? (2/2)
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??t?????a as?e???? st?? EHR (1/2)
???te??p???s? t?? e???af?? st?? EHR ap? µ?a
?at???? ep?s?e??
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??t?????a as?e???? st?? EHR (2/2) (DAMLOIL)
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???e? s?µa?t???? p??sp??e?e?

• Domain Specific Markup Languages
• ????at????? ??t?????e? (GO,MGED)
• ??9 ??a t?? ?µ??e??p???s? ?at????? ????
• HYGEIA NET

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??9 (?µ??e??p???s? ?at????? ????)

• X??s? t?? µe??d?????a? ONIONS (?ntologic
  Integration on Naïve Sources) ??a t?? a????s? ?a?
  ?µ??e??p???s? ??t??????? s???e???µ???? ped???
• ?ed?µ??a ap? 5 (ete???e??) s?st?µata ?at?????
  ???????a?
• UMLS-SN (MeSH, ICD9-CM, SNOMED II)
• ICD 10
• GMN
• SNOMED III
• CORE (GALEN project)

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HYGEIA net (1/3)

• Integrated Health Telematics Network of Crete

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HYGEIA net (2/3)
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HYGEIA net (3/3)
?at?????e? pa?e??µe??? ?p??es???

• ded?µ??a as?e???
• d?a?es?µ?t?ta ?a? ?ata??µ? p????
• s??e??as?a
• st????? ap?f?se??
• e?pa?de?s?
• ?p??es?e? p??st???µe??? a??a?

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Domain Specific Markup Languages
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????at????? ??t?????e?(RDF/RDFS/DAMLOIL)
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?????