Title: PHYSIOLOGY OF CONTROL OF BREATHING
1PHYSIOLOGY OF CONTROL OF BREATHING
Prof. Sultan Ayoub Meo MBBS, M.Phil, Ph.D (Pak),
M Med Ed (Dundee), FRCP (London), FRCP (Dublin),
FRCP (Glasgow), FRCP (Edinburgh) Professor and
Consultant, Department of Physiology, College of
Medicine, King Saud University, Riyadh, KSA
2REGULATION OF RESPIRATION
- Respiration is regulated by three different
mechanisms - Nervous regulation
- Chemical regulation
- Peripheral chemoreceptor control system.
3NERVOUS REGULATION
- Dorsal respiratory group
- Ventral respiratory group
- Pneumotaxic center
- Apneustic center
4NERVOUS REGULATION
5NERVOUS REGULATION
Controls automatic breathing. Consists of
interacting neurons that fire either during
inspiration (I neurons) or expiration
(E neurons).
6NERVOUS REGULATION
I neurons Located primarily in dorsal
respiratory group (DRG) Regulate activity of
phrenic nerve. Project to and stimulate spinal
interneurons that innervate respiratory
muscles. E neurons Located in ventral
respiratory group (VRG) Passive
process. Controls motor neurons to the internal
intercostal muscles. E neurons inhibit the I
neurons. Rhythmicity of I and E neurons may be
due to pacemaker neurons.
7NERVOUS REGULATION
Apneustic center Promote inspiration by
stimulating the I neurons in the medulla.
Pneumotaxic center Antagonizes the apneustic
center. Inhibits inspiration.
8DORSAL RESPIRATORY GROUP OF NEURONS
Dorsal respiratory group of neurons are located
bilaterally in the dorsal portion of the medulla
oblongata in / close to the nucleus of the
tractus solitarius. Dorsal group of neuron is
made up of I neurons. They receive afferents
from the air ways and carotid and aortic bodies
which terminate in the nucleus of tractus
solitarius.
9DORSAL RESPIRATORY GROUP OF NEURONS
Functions On stimulation initiate normal
inspiration Rhythmically discharges inspiratory
signals Inspiratory signals begin weekly and
increase in ramp fashion for 2 seconds, then
cease for next 3 seconds and then begin another
cycle.
10VENTRAL RESPIRATORY GROUP OF NEURONS
Ventral respiratory group of neurons extend
through the nucleus ambigus and nucleus
retroambigus in the ventrolateral part of the
medulla oblongata. The ventral group has E
neurons at its caudal end I neurons in its mid
portion E neurons at its rostral ends. The
neurons in the rostral end of this group appear
to inhibit I neurons during expiration.
11FUNCTIONS OF VENTRAL RESPIRATORY GROUP OF NEURONS
- Ventral respiratory group neurons are inactive
during normal quiet respiration. - Normal quiet breathing is caused by repetitive
inspiratory signals from the dorsal respiratory
group, transmitted mainly to the diaphragm.
Expiration results from the elastic recoil of the
lungs. - These neurons provide active role / strong
discharge during forceful expiration.
12PNEUMOTAXIC CENTER
- Pneumotaxic center located dorsally in the
nucleus parabrachialis of the upper pons,
transmits impulses to the inspiratory area. - Functions Transmit signals to the dorsal
inspiratory areas to switch off the inspiratory
ramp signals, controlling the duration of the
filling phase of the lungs. When these signals
are strong inspiration lasts for 0.5 sec. When
weak, inspiration lasts as long as 5 seconds,
filling the lungs with excess air. - Â Stimulation of the pneumotaxic center limits the
period of inspiration, Â It increases the rate of
respiration
13APNEUSTIC CENTER
- Apneustic center Situated in lower pons.
- Functions It send signals to the dorsal
respiratory group of neurons to prevents the
switch off of inspiratory ramp signals - Stimulation of this centre prolongs the period of
inspiration. - An increase in the duration of inspiration result
in a deeper and more prolonged inspiratory
effort. - The rate of respiration becomes slow because of
the greater depth of inspiration
14CHEMICAL REGULATION OF RESPIRATION
15CHEMICAL REGULATION OF RESPIRATION
- Respiratory system maintain the concentration of
CO2 and O2 - CO2 is most important stimulus for regulating
respiratory rate. - Effects of H and CO2 on the chemosensitive area
Effects of blood H ions H ions that provide
the important stimulus for regulating the rate of
respiration, blood H ions cannot effect the
chemosensitive area alone because it cannot cross
the blood brain barrier and blood C.S.F barrier. - Effects of blood CO2 Blood CO2 can cross the
blood brain and blood C.S.F barriers, CO2 in
blood combines with H2O to form carbonic acid.
This CO2H2O form H2CO3
16CHEMICAL REGULATION OF RESPIRATION
Carbonic acid rapidly dissociates into H ions
and bicarbonate (HCO3-) ions. Increase in CO2
will increase the H, but on the other hand a
decrease in CO2 will cause a decrease in H ions.
H ions stimulate the chemosensitive areas.
17Chemoreceptors
2 groups of chemo-receptors that monitor changes
in blood PC02, P02, and pH. Central
Medulla. Peripheral Carotid and aortic bodies.
Control breathing indirectly via sensory nerve
fibers to the medulla (X, IX).
18PERIPHERAL CHEMORECEPTORS
19PERIPHERAL CHEMORECEPTORS
20PERIPHERAL CHEMORECEPTORS
Effects of oxygen The peripheral chemoreceptors
detect changes in PO2. The arterial PO2 falls
from 104 mm Hg, impulses from these receptors are
carried to the brain via the vagus and
glossopharyngeal nerves, result in an increased
rate and depth of respiration. Effect of
decreased pH (increased H ions) Increased
alveolar ventilation lowers the PCO2 in the
arterial blood and reduces the amount of acid,
which tends to return the arterial pH to normal.
21PERIPHERAL CHEMORECEPTORS
- Effects of CO2 CO2 stimulates the peripheral
chemoreceptors. - Peripheral chemoreceptors are stimulated by
decreased or increased CO2, increased H ion
concentration, and decreased pH and low O2. When
peripheral chemoreceptors are stimulated, the
impulses transmitted from these receptor sites to
the dorsal inspiratory area causes the switch off
of the inspiratory ramp signals. Since the period
of inspiration becomes limited there is an
increase in the rate of respiration.
22CHEMORECEPTOR CONTROL
Central chemoreceptors More sensitive to changes
in arterial PC02. H20 C02 H cannot cross the
blood brain barrier. C02 can cross the blood
brain barrier and will form H2C03. Lowers pH of
CSF. Directly stimulates central chemoreceptors.
23CHEMORECEPTOR CONTROL
- Peripheral chemoreceptors
- Are not stimulated directly by changes in
arterial PC02. - H20 C02 H2C03 H
- Stimulated by rise in H of arterial blood.
- Increased H stimulates peripheral
chemoreceptors.
24CHEMORECEPTOR CONTROL OF BREATHING
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