1790-bp

1
Frequent somatic mutations of the transcription
factor ATBF1 in human prostate cancer Nature
Genetics 37 407-412, April 2005
???16? ??????? ?? (Oncogene 2001), ?? (Clin.
Can. Res 2005), ???? (Nat. Genet. 2005),
glioblastoma multiforme, medulloblastomas,
primitive neuroectodermal tumors, a primitive
neuroectodermal tumor of the pineal region,
primary ependymomas, primary ependymomas (57),
neurofibroma, acute myeloid leukaemia,
myofibromatosis, familial AML,pulmonary
adenocarcinoma, small cell lung carcinoma,
malignant adipose tissue tumors, malignant
peripheral nerve sheath tumor, nephroblastomas,
hepatocellular carcinomas, acute B-cell
lymphoblastic leukemia, gallbladder carcinoma,
multiple myeloma, tuberous sclerosis and sporadic
lymphangiomyomatosis, autosomal dominant
cerebellar ataxia, type I psoriasis.
ATBF1??????
100
200
300-kb
0
?????
11447
ATBF1-A
87548
60518
81331
17741
127
1312
4407-bp
6460
P1
P2
ATG
9
0
1
2
3
4
5
6
7
8
10
623
2769
498
232
81
133
201
5460
1790-bp
103
????

ATBF1-B J. Bio. Chem. (1995)
Nat.Genet. (April 2005)
P2??????????????? P1?ATBF1-B???????????????????? ?
???9????????????????DNA??????????????(??ATBF1?????
??????????---?????)