CD molecules

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CD molecules

• Disease

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  2000??????

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CD molecules disease

• Concept
• CD molecules,which are also called leukocyte
  differentiation antigen,are the surface markers
  appear or disappear on leukocytes (also include
  platelet,blood vessel endothelial cell etc)
  during the process of differentiation and
  activation.

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CD molecules disease

• According to monoclonal antibody identification
  method,the same differentiated antigen that can
  be recognized by monoclonal antibody coming from
  different labs are called CD (cluster of
  differentiation)

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CD molecules disease

• Structure
• Most CD molecules are transmembrane protein or
  glycoprotein,including extramembrancous,transmembr
  anous and intracellular areas.

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CD molecules disease

• Classifications
• CD molecules are numbered according to the
  time of discovery.So far,they have been named
  from CD1 to CD166.

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Classification CD Serial Number
T cell cd1cd8,cd27,cd28,cd60,cd98cdw101
B cell cd10,cd19cd24,cd37,cd39,cd40,cd72cd86
Activated cell cd25,cd26,cd30,cd69cd71,cd95cd97
Myeloid cell cd9,cd11bcd17,cd31cd36,cd64cd68,cd87cd93,cd115
NK cell cd11a,cd18,cd29,cd38,cd43,cd45cd48,cd52cd59,cd94
Platelet cell cd41,cd42,cd63,cd107
Endoepithelial cell cd105,cd106,cdw109
Adhesion molecule cd11a,cd44,cd49cd51,cd61,cd62,cd102 cd104,cdw108
Cytokine receptor cdw116,cd117,cd120cd122,cd124,cd126 cdw128,cdw130
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CD molecules disease

• All of them are classified approximately into
  9 groups
• T cell, B cell, activating cell, myeloid
  cell, NK/non-lineage cell, platelet,
  endoepithelial cell, adhesion molecule and
  cytokine receptor .

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CD molecules disease

• Function
• 1. CD molecules take part in the recognition
  between immune cells and Ag or other immune
  cells.They also participate the
  activation,proliferation differentiation and
  immune function.

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CD molecules disease

• 2.Regulate the differentiation and migration of
  hemopoietic cells.
• 3.Participate inflammation.
• 4.Cell migration.
• eg.cancer matastasis

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CD molecules disease

• Cdmolecules and disease
• 1.CD moleculesnormal functions
• 1)CD molecules related to activation of T
  cell ,TCR/CD3 Complex,CD4 Co-
  receptor,CD8,CD2,CD58,CD28- Co- stimulators

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CD molecules disease

• 2).CD molecules related to inflammatory
  reactions.
• FirstlyCDb2I and CDb2E mediate neutrophiles to
  roll and combine,the monoclonal Ab that
  until-selection can inhibit the reaction
  dramatically
• When passing through endothelium, CD4/CD18
  interacts with its ligand,playing an important
  role.

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CD molecules disease

• 3).CD associated with blood cloting
• eg GP16

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CD molecules disease

• 2.Disease
• 1)EB LFA-3 lacking
• 2)Paroxys nocturnal hemoglosinvia(?? ????? )
• CD6 CD28 T cell MHC
• CD8 CD28- inhibit antibody

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CD molecules disease

• 3)Disease associated with intracellular signals
  transmission of CD,CD3,CD45,CD115,CD125,CD117,CD13
  0,their signalsabnormal transduction cause
  hyperplastic disease,whats more,they are
  intimately involved in tumor,papillomas,psoriasis,
  etc.

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CD molecules disease

• 4)CD and tumors
• (1) CD44 and cancer (tumor) metastasis
• eg melanomatous cells express CD44
• The inflammayion products and some
  cytokines promotes local vessels endothelial
  cells to express more CAMs,which are helpful to
  the adhesion of tumor cells

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CD molecules disease

• (2)Stimulation of CD40 can inhibit the
  reproduction of tumor cells directly,promote
  apoptosis and Fasgene expression
• (3)The interaction between LFA-I and ICAM-1
  mediate the contant between NK cells and tumor
  cells.

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CD molecules disease

• ICAM-2 Mutations Affecting LFA-1 Binding
  

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CD molecules disease

• 5)CD and HIV.
• HIV enters the T cell by combining with CD4
  molecules on T cells.In the blood of the person
  infected by HIV-I,CD4 cell appears positive.The
  CD4 cellsobvious decrease is associated with
  the disease deterioration.

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CD molecules disease

• HIV infecting normal humans tissues

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CD molecules disease

• 6)CD and GSS (Granulomatous slack skin?????????)
• Mainly CD4 CD8- T cells and CD45RO T cells
  antigen loss in different measures.
• CD4/CD45RO T cells, CD3, CD5 and CD7
  (marker of T cells) loss.

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CD molecules disease

• 7)CD and CO poisoning
• CO poisoning damage the endothelial cells
• The activation of platelets increase and
  CD116, CD18 are highly expressed.
• Thrombus in cerebral microarterial vessels is
  induced to form.

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CD molecules disease

• 8)CD and diabetes -I
• Immune tolerance deficiency of insular
  specific T cells is due to blockage of
  ICAM-I/CFA-1 and loss CD8 T cells at the
  beginning of immune response,which lead to
  insular antigen tolerance deficiency.

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CD molecules disease

• 9)Others
• Increasing of activators of platelet-CD62P,CD61,
  and CD41,especially CD62P,are closely related to
  the disease such as coronary heart
  disease,cerebral infarction,hypertension,etc.

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CD molecules disease

• Associated with endometriosis.(??????)
• egPeriodical change of CD45 cell group
  become abnormal.
• The disease such as asthma,rhinitis,etc are
  possibly associated with actiration of CD8 and
  CD127 cells

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CD molecules disease

• Anusual expression of CAM and SLE
• SLE (systemic lupus erythematosus???????)
• CD11a and CD18 expression decline agree with
  CD4 T cell while increase with CD8 T cell.
• Expression of CD54 on CD20 cells increase

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CD molecules disease

• CD molecules and clinical treatment
• 1.CD34 and Aplastic anemia (???????)
• CD34 is expressed in most acute lympholeukemia
  (??????????)
• Detection of CD34 is helpful to the study of
  Aplastic anemia

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CD molecules disease

• 2.CD34 as marks of T cells
• MACS is used to select and separate CD34 T
  cells from peripheral blood
• Reduced T cell-load is good for autoimmune
  disease

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CD molecules disease

• 3.Application of anti-CD40 McAb
• anti-CD40 McAb can significantly inhibit the
  development of Osseous rheumatism(???????)

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CD molecules disease

• 4.Application of anti-CD3- Ab
• anti-CD3-Ab is now widely used to cure
  enograft rejection and is efficient
• bispecific anti-CD3-/HSV Ab for treatment of
  the immunodeficient newborn infected by HSV

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CD molecules disease

• 5.Anti-CD3 McAb
• 1)anti-CD3McAb in mice can reverse enograft
  rejection
• 2)Mechanism
• anti-CD3 McAb can bind with CD3 molecules on
  T cells

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CD molecules disease

• The interaction interfere with the transduction
  of activating signals which results in cytokine
  releasing
• The proliferation and functions of T cells be
  blocked

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