North Carolina Biotechnology Center

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North Carolina Biotechnology Center Science
Technology Development Program
North Carolina Biotechnology Center Strengthening
North Carolinas Research Infrastructure
Science Technology
October 2006
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About NCBC
North Carolina Biotechnology Center Science
Technology Development Program

• Private, non-profit economic development
  organization.
• Created by the General Assembly in 1981 became a
  non-profit in 1984.
• MISSION
• To provide long-term economic benefit to North
  Carolina through support of biotechnology
  research, development and commercialization
  statewide.

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Center Programs Initiatives
North Carolina Biotechnology Center Science
Technology Development Program

• Core Programs
• Education Training
• Science Technology Development
• Business Technology Development
• Initiatives
• Institute for Forestry Biotechnology
• NC Genomics Bioinformatics Consortium

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North Carolina Biotechnology Center Science
Technology Development Program
Science Technology Development
Investing in University Development and Research
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North Carolina Biotechnology Center Science
Technology Development Program
North Carolina Biotechnology Center
biotech regions are leaders because they have
two necessary elements for industry growth
strong research capacity and the ability to
convert research into successful commercial
activity. Signs of Life, Brookings
Institute Report if you want excellence in
biotechnology, youd better put your backing
where youll winthe universities and places with
the infrastructure to support it. Max
Wallace, Biotechnology and Emerging Issues
report, section on Regional Initiatives
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Pyramid of Biotechnology Economic Development
North Carolina Biotechnology Center Science
Technology Development Program
Large-size Companies
Mid-size Companies
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Start-up Companies
IP, Tech Transfer, Licensing
Federal Research Funding
University Infrastructure
Science Math Education
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North Carolina Biotechnology Center Science
Technology Development Program
Our Mission

• The Science Technology Development Program
  works to strengthen North Carolina universities
  so they can serve as foundations for
  biotechnology economic development by
• Enhancing the ability of universities to attract
  federal funding
• Funding research of commercial interest

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North Carolina Biotechnology Center Science
Technology Development Program
Program Goals
Encourage multidisciplinary collaborative research
Move IP from lab to commercialization
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Provide core facilities equipment
Support faculty recruitment
University Infrastructure
Provide venues for intellectual exchange
Enhance high performance computing capabilities
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North Carolina Biotechnology Center Science
Technology Development Program
Development Tools

• Grant Programs
• Intellectual Exchange Groups

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North Carolina Biotechnology Center Science
Technology Development Program
Grant Programs
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North Carolina Biotechnology Center Science
Technology Development Program
Grant Programs
Overall Purpose Fund cutting-edge research in
its very early stages. Serve as a stepping stone
to larger sources of funding Enable researchers
to gather preliminary data and go on to secure
federal funding.
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North Carolina Biotechnology Center Science
Technology Development Program
Biotechnology Research Grant (BRG)

• Purpose Seed funding for novel research projects
  at non-profit research institutions in the early
  stages of building their research capacity.
• Funding to generate preliminary data to include
  in applications for federal grants.
• Support for junior faculty members.

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Biotechnology Research Grant (BRG)
North Carolina Biotechnology Center Science
Technology Development Program
Funding Level 75,000 max 10 minimum matching
requirement Application deadline February 7,
2006
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Note Investigators from the main campuses of
Duke, NC State and UNC-Chapel Hill are not
eligible to apply.
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North Carolina Biotechnology Center Science
Technology Development Program
Collaborative Funding Grant (CFG)
Purpose Support a postdoctoral fellow in a
university research laboratory who will perform a
project of commercial interest under the guidance
of a principal investigator.
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• Program encourages collaboration between academia
  and industry
• Helps to move technology from the lab to
  commercialization
• Leverages our money with the Kenan Institute

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North Carolina Biotechnology Center Science
Technology Development Program
Collaborative Funding Grant (CFG)
4-way partnership

• NCBC
• Kenan Institute
• University
• Company Partner

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Total package 60K in cash 20K in-kind 80K
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North Carolina Biotechnology Center Science
Technology Development Program
Collaborative Funding Grant (CFG)
Return on Investment Nearly 30 for every 1
awarded by NCBC
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Two deadlines per year July 12, 2006 January 17,
2007
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North Carolina Biotechnology Center Science
Technology Development Program
Institutional Development Grant (IDG)
Purpose Build research infrastructure via core
facilities and equipment.

• Funding core facilities and multi-user equipment
  allows us to leverage our resources to have as
  great an effect as possible.
• Requires
• No duplication of equipment
• Use by at least six investigators
• Administrative plan

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Institutional Development Grant (IDG)
North Carolina Biotechnology Center Science
Technology Development Program
Funding Level 250,000 max 25 minimum capital
costs matching requirement Application
deadline September 6, 2006
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IDG Examples
North Carolina Biotechnology Center Science
Technology Development Program
Patch clamp/ confocal imaging
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Visualsonics VS40 ultrasound system
ABI PRISM 3100 Genetic Analyzer
DNA Microarray System
Gnotobiotic Core Facility
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North Carolina Biotechnology Center Science
Technology Development Program
Faculty Recruitment Grant (FRG)
Purpose Aid recruitment of new faculty who will
further an academic institutions overall
biotechnology initiative.
Return on Investment Nearly 20 for every 1
awarded by NCBC
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To date there have been 36 successful
recruitments including Andrew Thorburn (WFU),
Jeffrey Wright (UNC-W), Ed Stellwag (ECU), Mary
J. Thomassen (ECU), Ken Bost (UNC-C). Duke, NC
State and UNC-Chapel Hill are not eligible to
apply.
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Faculty Recruitment Grant (FRG)
North Carolina Biotechnology Center Science
Technology Development Program
Funding Level 150,000 max 100 matching
requirement Application deadline Any time
after position has been formally advertised.
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Multidisciplinary Research Grant (MRG)
North Carolina Biotechnology Center Science
Technology Development Program
Purpose Seed funding to establish new,
innovative research collaborations.

• As the field of science broadens, it incorporates
  expertise from a variety of disciplines.
• Often one person does not have all the knowledge.
  
• This program encourages 3 or more scientists from
  different disciplines to work together on big
  programs.

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North Carolina Biotechnology Center Science
Technology Development Program
Multidisciplinary Research Grant (MRG)

• Research must have
• Potential practical benefits
• 3 or more investigators (all NC-based)

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Funding level 250,000 max 10 matching
requirement Application deadline October 4, 2006
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North Carolina Biotechnology Center Science
Technology Development Program
MRG Project Examples
Development of a Method for Treatment of Brain
Injury using Embryonic Stem Cells (ECU)
Generation of a Zebrafish Model for Alzheimers
Disease (NCCU and Duke)
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Recovery of High Value Nutraceuticals Using a Gas
Anti-Solvent (GAS) Process (NC State and UNC
Pembroke)
Engineered Nanoparticles for Delivery of NO to
Decrease Ischemia/Reperfusion Injury in the Heart
(ECU) and (UNC-CH)
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North Carolina Biotechnology Center Science
Technology Development Program
Funding Rates for 2005-2006
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Only two FRG applications were submitted during
this time and both were funded.
Funding success rate for federal grants new R01
research grants at NIH during the 2005 fiscal
year was 17.9 and success rate for all new
grants was 18.8. Funding success rate for
federal grants is from the NIH Office of
Extramural Research data posted for Fiscal year
2005.
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IDG Funding Data
North Carolina Biotechnology Center Science
Technology Development Program
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Research Extensive
Research Intensive
Submission rate for research intensive
institutions is 20 for FY 2007.
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North Carolina Biotechnology Center Science
Technology Development Program
Intellectual Exchange Groups
Purpose Promote ongoing intellectual exchange
and collaboration among academic and industrial
researchers on basic and applied research
topics. Support Varies according to the needs
of the IEG.
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North Carolina Biotechnology Center Science
Technology Development Program
Intellectual Exchange Groups
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North Carolina Biotechnology Center Science
Technology Development Program
Other Grant Programs at NCBC

• Biotechnology Event Sponsorship
• Biotechnology Meeting Grant
• Education Enhancement Grant
• Regional Development Grant

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North Carolina Biotechnology Center Science
Technology Development Program
Biotechnology Event Sponsorship
Purpose Support events that advance the
understanding or application of biotechnology to
benefit North Carolina. Promote information
sharing and personal interaction focused on
biotechnology research, education or business.
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Funding level 3,000 max Application deadline 45
days prior to event
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North Carolina Biotechnology Center Science
Technology Development Program
Biotechnology Meeting Grant
Purpose This grant promotes and supports
national and international meetings which advance
the understanding or application of biotechnology
and focus national and international attention on
the North Carolina scientific community.
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Funding level 10,000 max Application deadline 3
months prior to event
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North Carolina Biotechnology Center Science
Technology Development Program
Education Enhancement Grant
Purpose To assist development of activities,
programs, resources, and personnel necessary for
biotechnology education and training in
well-defined educational settings statewide.
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Funding level 100,000 max Application
deadline August 9, 2006
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North Carolina Biotechnology Center Science
Technology Development Program
Regional Development Grant
Purpose To assist in early stage life science
economic development initiatives in communities
statewide. Types of projects that can be funded
include but are not limited to strategic
planning, marketing, infrastructure building, and
other activities that build regional and
community collaborations to foster growth of
biotechnology companies, related industries, and
their service providers.
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North Carolina Biotechnology Center Science
Technology Development Program
Regional Development Grant
Funding level Up to 75,000 may be requested 50
matching requirement
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Application deadline Pre-proposal August 2,
2006 January 24,
2007 Proposal September 27, 2006
March 21, 2007
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North Carolina Biotechnology Center Science
Technology Development Program
NIH Regional Seminar
A grantsmanship seminar to be held on April
24-26, 2007 at the Sheraton Imperial Hotel
located in RTP Jointly sponsored by
Duke North Carolina Biotechnology Center, North
Carolina Central University North Carolina State
University RTI International University of North
Carolina at Chapel Hill
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For more information please go to
http//grants1.nih.gov/grants/seminars.htm
OR Coming soon to the NCBC website (November 06)
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North Carolina Biotechnology Center Science
Technology Development Program
Contact Information
Maria Rapoza, Vice President maria_rapoza_at_ncbiote
ch.org Sandra Santulli-Marotto, Manager
sandra_santulli-marotto_at_ncbiotech.org
Nicki Williams, Program Specialist
nicki_williams_at_ncbiotech.org Ginny DeLuca, Core
Programs Specialist virginia_deluca_at_ncbiotech.org
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Staff Directory www.ncbiotech.org/contact/staffd
ir.cf