Genetic Diseases and Blood typing

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Genetic Diseases and Blood typing
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Most genetic diseases are recessive

• Sickle Cell Anemia-most common in those whose
  ancestors lived near equator. Ss-not susceptible
  to malaria!
• Cystic Fibrosis (CF)-most common in Europeans,
  Cc-more likely to survive Cholera. RIP young-30s?

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More Recessive Diseases

• PKU-phenylketonuria-cant digest amino acid
  phenylalanine, treat, special diet
• Tay-Sachs-most common in those of Jewish decent,
  RIP young, cant prevent.Missing an enzyme to
  break down GM2-becomes toxic, no cure

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Few Dominant Diseases? Why?

• Huntingtons-dominant, appears mid-late life
• nervous system degeneration
• dance-like movements
• memory loss
• death-5-10 yrs later

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Why isnt incest best?

• The blue people-recessive disorder
• blue people kept passing blue gene by
  intermarriage
• Most people carry genes for a recessive disease
• More likely for relatives to carry same recessive
  disease

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Interesting recessive traits

• albinism

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Blood types

• What is different?
• Antigen-nametag, it ids the cell type
• You can accept blood that has fewer antigens,
  but not different or more

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Whose blood can you get?

• Type A-gets Type A or Type O blood
• Type B-gets Type B or Type O blood
• Type AB-can accept ALL (univeral acceptor)
• Type O-can only get O (universal donor)

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How blood Works

• Give the genotypes for these blood phenotypes
• Type A
• Type B
• Type AB
• Type O

• A and B CODOMINATE
• A will dominate O
• B will dominate O

AA or AO
BB or BO
AB
OO
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Try this

• Henrietta has Type A blood and Earl has Type B.
  What are ALL of the possible blood types that
  their kids can have?

Type A, Type B, Type AB, Type O
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Rh Factor

• Rh factor is another antigen that is or is not on
  your blood cells

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Rh incompatibility

• Mom is Rh-, baby is Rh
• If mom is exposed to babys blood, she makes
  antibodies against babys blood
• Prevent-drugs to stop antibodies