Blood flow to the uterus

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Blood flow to the uterus
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Fig. 28-19a, p. 1055
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Fig. 28-19b, p. 1055
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Fig. 29-3, p. 1080
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spiral arteries
Fig. 29-4, left, p. 1081
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Fig. 29-5a, part 1, p. 1083
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Fig. 29-5a, part 2, p. 1083
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Fig. 29-6, p. 1084
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Fig. 29-6a, p. 1084
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Changes in Cardiovascular Function During
Pregnancy

• ? blood volume
• ? cardiac output
• ? peripheral resistance
• ? arterial blood pressure

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Changes in Renal Function During Pregnancy

• ? renal blood flow
• ? GFR
• ? renin-angiotensin-aldosterone

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Preeclampsia

• usually develops during 3rd trimester
• ? peripheral resistance
• ? GFR
• proteinuria
• ? blood flow to the placenta

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The Rat Model
reduced uterine perfusion pressure
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Rats with occluded placental blood flow have
reduced response to vasodilators (Ach)
blood vessels remain constricted, causing an
increase in arterial pressure
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It seems that the hypertension may be due to
increased release of endothelin by the endothelium
endothelin levels are increased in women with
preeclampsia
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(No Transcript)
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A theory in search of some data