Figure 1'

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Figure 1.
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• Figure 1. A pictorial representation of a
  nanoscale process with supramolecular unit
  operations, scaffold and transport mechanisms.
  The two units are nanoreactors (top left --
  Richeter and Rebek, 2004 bottom right Kang and
  Rebek, 1997). The structural scaffold can be made
  of (a) crossed semiconductor nanowires (Zhong et
  al., 2003) or (b) DNA tiles (Park et al., 2005).
  Between the supramolecular unit operations,
  molecules may be transported selectively through
  (a) shuttles (Balzani et al., 2000), (b) motors
  (Sherman and Seeman, 2004) and (c) nanotubes
  (Blau and Fleming, 2004).

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Figure 2.
4

• Figure 2. A pictorial representation of nanoscale
  signaling and energy use. In the first
  nanoreactor unit, a signaling network similar to
  (a) Gianneschi et al., 2004 occurs, where a
  signal, P1, triggers a conformation change in S1.
  This change catalyzes the reaction of R1 and R2
  to form P2 and P3. P3 is then transported to the
  second nanoreactor unit, where it is a trigger
  for a reaction similar to (b) Meijer and van
  Genderen, 2003. P3 triggers the dendrimer to
  self-destruct and release its cargo, P5. One can
  envision the dendrimer, R3, being an energy
  storage unit that releases energy-providing P5
  molecules when they are needed in the system.

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• References
• Reactor (top left) Richeter, S., J. Rebek, Jr.,
  Catalysis by a Synthetic Receptor Sealed at One
  End and Functionalized at the Other, Journal of
  the American Chemical Society, 126, 16280 (2004).
• Reactor (bottom right) Kang, J., J. Rebek,
  Acceleration of a Diels-Alder reaction by a
  self-assembled molecular capsule, Nature, 385,
  50 (1997).
• Transport (a) Balzani, V., A. Credi, F. M.
  Raymo, J. F. Stoddart, Artificial Molecular
  Machines, Angewandte Chemie International
  Edition, 39, 3348 (2000).
• Transport (b) Sherman, W. B., N. C. Seeman, A
  Precisely Controlled DNA Biped Walking Device,
  Nano Lett., 4, 1203 (2004).
• Transport (c) Blau, W. J., A. J. Fleming,
  Designer Nanotubes by Molecular Self-Assembly,
  Science, 304, 1457 (2004).
• Scaffold (a) Zhong, Z., D. Wang, Y. Cui, M. W.
  Bockrath, C. M. Lieber, Nanowire Crossbar Arrays
  as Address Decoders for Integrated Nanosystems,
  Science, 302, 1377 (2003).
• Scaffold (b) Park, S. H., P. Yin, Y. Liu, J. H.
  Reif, T. H. LaBean, H. Yan, Programmable DNA
  Self-Assemblies for Nanoscale Organization of
  Ligands and Proteins, Nano Letters, 5, 729
  (2005).

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P1
P3
S1
S1
R3
P4 P5
R1 R2
P2 P3
Signaling and Energy
Scaffold Flowsheet
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Transport
Reactor
(b)
(a)
(c)
Reactor
Scaffold
(a)
(b)
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(b)
(a)
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• References
• Reactor (top left) Richeter, S., J. Rebek, Jr.,
  Catalysis by a Synthetic Receptor Sealed at One
  End and Functionalized at the Other, Journal of
  the American Chemical Society, 126, 16280 (2004).
• Reactor (bottom right) Kang, J., J. Rebek,
  Acceleration of a Diels-Alder reaction by a
  self-assembled molecular capsule, Nature, 385,
  50 (1997).
• Transport (a) Balzani, V., A. Credi, F. M.
  Raymo, J. F. Stoddart, Artificial Molecular
  Machines, Angewandte Chemie International
  Edition, 39, 3348 (2000).
• Transport (b) Sherman, W. B., N. C. Seeman, A
  Precisely Controlled DNA Biped Walking Device,
  Nano Lett., 4, 1203 (2004).
• Transport (c) Blau, W. J., A. J. Fleming,
  Designer Nanotubes by Molecular Self-Assembly,
  Science, 304, 1457 (2004).
• Scaffold (a) Zhong, Z., D. Wang, Y. Cui, M. W.
  Bockrath, C. M. Lieber, Nanowire Crossbar Arrays
  as Address Decoders for Integrated Nanosystems,
  Science, 302, 1377 (2003).
• Scaffold (b) Park, S. H., P. Yin, Y. Liu, J. H.
  Reif, T. H. LaBean, H. Yan, Programmable DNA
  Self-Assemblies for Nanoscale Organization of
  Ligands and Proteins, Nano Letters, 5, 729
  (2005).