aap Implantate AG at a Glance

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aap Implantate AGat a Glance
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Overview
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Overview aap

• European MedTech company
• Based in Germany (aap) / The Netherlands (Fame)
• Listed at Frankfurt Stock Exchange
• Activities Biomaterials, Trauma/Orthopedics,
• Revenue comb. of approx. 33m (07p 40m),
  profitable
• Staff of 260, thereof 25 RD
• Founded 1990

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aap Business Segments
Orthopedis
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aap Traumatology Orthopedics

• Implants for fracture healing andjoint
  reconstruction
• Main offices in Berlin
• 100 employees (including group management)
• Fields of Expertise
• Trauma (plates, screws, nails, pins)
• Shoulder
• Hip
• Knee
• Surgical products for orthopedics
• In-house development and production
• Direct sales in Germany
• International network of distributors

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aap Biomaterials

• Main Offices in Dieburg (Germany) and Nijmegen
  (Netherlands)
• 160 employees
• Fields of Expertise
• Bone cements
• Bone substitutes
• Tissue regeneration
• Infection therapy
• In-house development and production
• Internationally leading OEM manufacturer in the
  area of bone cements
• International network of distributors

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Product OverviewTrauma
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Trauma Expertise at a Glance

• More than 25 years of experience in the
  development, manufacture, marketing and sales of
  trauma products
• In-house research and development accompanied by
  a scientific advisory board
• Company-owned modern production in Berlin
• Broad product spectrum both in standard
  productsand in patented or patentable innovative
  products
• Wide product portfolio for standard
  osteosynthesis Plates (T-, L-, quarter round
  and reconstruction plates, etc.) for mini-,
  small, and large fragments), cortical and
  spongiosa screws, cannulated screws
• Product portfolio with innovative products
  System of angle-stable plates (fixed angle
  round-hole plates, angle-stable sliding hole
  plates)
• Direct sales and marketing in Germany with 10
  regional District Managers
• Listed main supplier in several purchasing
  consortiums and conjoint clinics Helios, PEG,
  ProSpitalia, EKK, AGKMED, etc.
• Export activities to more than 25 countries with
  an extensive distributor network

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Trauma Expertise Spectrum of Services

• Products with good price-performance ratio
• A broad product spectrum for covering
  comprehensive indications in more than 60 of
  the following fracture areas
• Service Package
• Intensive customer care on site by company field
  service
• Various workshops and seminars directly at the
  clients location or in the company center
• With regard to our products, hospitalization
  options for our customers at our referral clinics

Foot Cranium 3 6
Neck 1 Chest 6 Lower Leg
Lower Back 22 8 Shoulder 12 Femu
r 21 Hand Lower Arm
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Source Federal Statistical Office Specialty
Series 12 / Volume 6.2.1 2003
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Standard plates
2.7 mm
2.0 mm
Reco plate
oblique L-plate
T-plate
straight
L-plate
straight
3.5 mm
Reco plate
T-support plate
Straight- plate
oblique T-plate
Clover plate
AC plate
4.5 mm
Reco plate
T-support plate
Halfround plate
L-support plate
Wide plate
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Standard screws

• Titanium and steel cortical screws
• Titanium and steel spongiosa screws

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Cannulated screws

• Extensive assortment for covering a wide spectrum
  of indications
• Material Titanium alloy
• Self-cutting, self-tapping
• Backward self-cutting
• A well-matched, color coded instrument set
• Small cannulated screw system
• CS 2.7 (TG, long short)
• CS 3.5 (VG, TG)
• CS 4.0 (VG, TG)
• CS 4.5 (VG, TG, 6 mm)
• Large perforated screw system
• CS 5.8 (16 mm)
• CS 6.5 (16 mm)
• CS 7.5 (8 mm, 16 mm, 32 mm)

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AcroPlate

• Anatomically matched hook plate for safe and
• uncomplicated care of AC joint injuries
• For AC luxations and lateral clavicle fractures
• 2 lengths 3 and 4 hole
• In steel and titanium

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Angle-stable Plates  Round hole WSP (1)

• Anatomically pre-formed
• Different plate lengths
• New type of spherical threading on the screw head
  and in the plate hole that even allows the use of
  standard screws
• Compact set with radius and humerus plates

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Angle-stable Plates  Round hole WSP (2)

• With straight plates double protection of the
  periosteum!
• No contact pressure due to angle stability
• Low contact surface by virtue of specially
  processed underside
• Angle-stable straight round hole plate
• Angle-stable reconstruction plate

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Angle-stable Plates  Sliding Hole WSG (3)

• Axial compression of 3 mm and angle-stable in one
• Minimized contact area
• Double protection of the periosteum
• No contact pressure due to angle stability
• Low contact surface by virtue of specially
  processed underside

Axial compression max. 3 mm compression
Fixed angle
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Product OverviewOrthopedics
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Field of Expertise Orthopedics at a Glance

• In-house research and development accompanied by
  a scientific advisory board
• Company-owned modern production in Berlin
• Well-rounded hip replacement program
• Cemented and cementless straight shaft system
• Cemented and cementless anatomical hip system
  with variable cone
• Cemented and cementless anatomical hip system
  with fixed cone
• Cemented and cementless anatomical revision hip
  system with variable cone
• Direct sales and marketing in Germany with 10
  regional District Managers
• Export activities with expandable network of
  distributors

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VarioFit and SM-Straight Stem

• VarioFit
• Split anatomically formed hip prosthesis
• Intraoperative variability and accuracy in the
  restoration of patient-specific hip anatomy
• 2 variants cemented and cementless
• SM-Straigt Stem
• Cemented hip replacement
• Combines clinical reliability with high economy
• A multitude of application options in the
  cemented area and in hybrid versions with
  cementless acetabular components

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Hip Replacement Systems cementless
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Hip Replacement Systems cemented
Mueller Cup Advance
Bipolar head
chromium-nickel head ceramic head
cobalt-chromium head
VarioFit cones
Mueller Straight stem
VarioFitClassic
VarioFit
absorbable cement stopper
non-absorbable cement stopper
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Hip Replacement Systems revision
cemented cementless Titanium cage
VarioCup
Biosphere I I Mueller Cup Advance
PE-Inlay
PE-Inlay with 10 Offset
ceramic inlay Chromium-nickel head
cobalt-chromium head
ceramic head
VarioFitcones
VarioFit
Revision
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Trauma Shoulder System

• Trauma prosthesis for functionally adapted care
  of comminuted fractures of the humerus head
• Modular prosthesis system for intra-operative
  adaptation to individual circumstances
• Adaptation of length (using intermediate plates),
  lateral offset (by means of different neck
  lengths) and rotation (using geared rims on the
  connection surfaces of the modules)
• Unique, individual, stabile fixation of the
  rotator cuff with pins without destruction of
  the residual blood supply in 72 possible fixation
  points

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Shoulder Replacement System

Short neck Long neck
Shoulder head Normal dimensions
Length 20 mm Narrow dimensions Length
25 mm Trauma shoulder module
Fixation screws
Spacer disk
Spacer disk with eyelets Long
Medium Short
Stem module
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Knee Replacement  Mebio Knee

• Proven uncoupled total surface replacement
• Cemented
• Constructionally identical to the Scan-Knee that
  is documented in the Swedish Knee Replacement
  Register
• Universal implant appropriate for the right and
  left knee
• All femur and tibia compo-nents combinable with
  each other
• Broad spectrum of tibia inlays (6  21 mm
  height) for all tibia components
• New instrument set

Femur components cementable
Plateau height PE-Inlay Patella
Tibia components
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Product OverviewBone Cements
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Bone cements

• Indication Fixation of endoprostheses
• Portfolio
• Cements
• Vacuum mixing systems
• High-pressure rinsing systems
• Filled product pipeline
• Potential for further OEM partnerships
• Global market approximately 250 million , of
  this the manufacturer part approx. 60 million
  (aap market share approx. 15), market growth in
  the case of joint reconstruction cements approx.
  8 10 p.a. and in the spine sector approx. 20
  
• Challenges Expanded application potential in the
  area of spine, combination products with better
  integration behavior, new antibiotic
  combinations, improved forms of
  application/administration (pre-packed)

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EASYMIX

• For mixing of bone cement with or without vacuum
• For the reduction of inhomogeneities and air
  inclusions in the cement
• For increased permanent mobility
• For reproducible cement quality
• For simple, retrograde application of the bone
  cement

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Lavage System Hi Speed Pulse Lavage

• Air pressure driven lavage system
• For cleaning the bone bed in implantations
• For clean-up of the bone in fractures
• For wound cleaning
• Minimizes the risk of fat embolism
• Minimizes the risk of aseptic loosening
• Optimizes micro-Interlocking between bone and
  cement

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Product OverviewBiomaterials
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Field of ExpertiseBiomaterials at a Glance

• Focus on B2B Development, Production, Clinical
  Marketing
• One of the internationally leading manufacturers
  of bone cements
• High-growth niche markets
• High development intensity (new supporting and
  active materials, thereby creating interfaces to
  the pharmaceutical industry)
• Central nano-technology platform (nanoparticles
  analogous to bone)
• Collaborations with large joint reconstruction
  companies

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Overview aap Biomaterials (incl. Fame Group)

• Roots at Merck Biomaterials, gt30yrs experience
• Focus areas bone cements, bone graft
  substitutes, infection care, tissue regeneration
• Indications in orthopedics, trauma, spine, dental
  and soft tissue (new)
• 2006 revenue of 25m (incl. analytics), 2007p
  32m
• Focus B2B, but range of own products via
  international distribution network
• Emphasis on development, regulatory, clinical
  network, production
• Excellent technology and IP position
• Relationships with global players on product /
  production level (Biomet, Smith Nephew,
  Synthes, Wright, JJ Depuy, Aesculap more to
  come)

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Portfolio Pipeline aap Biomaterials
Bone Cements
Infection Care
Orthopedic bone cements C-Ment OEM
Biomet BonOs OEM SN div. OEM
Pre-loaded Collagen 1 fleece Jason G
Synth. AB-Carrier PerOssal
Vertebroplasty BonOs Inject Vebroplast Vertelast
div. OEM/PL
Bone Plugs C-Plug div. OEM C-Plug G
Vac-Mixing Easymix C-Vac Prepack
div. OEM Septopal Osteoset
Multiantibiotic Cement
aap Biomaterials FAME
Spacer
Bone Graft Substit.
Tissue Regeneration
Combinations with collagen peptides
Xenografts Cerabone
Collagen 1- based membranes fleeces
Haemostyptika
Synthetics Ostim Artosal Osteocem OEM
Allografts Osnatal Processing
Adhesions-Barriers Rebasol
div. OEM Adcon
CE-approved
Approval process
Further products in urology and medical esthetics
Development
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Bone substitutes

• Portfolio
• Xenografts (bovine origin)
• Synthetic materials
• Global market approximately 750 mio. with
  approx. 15  market growth
• Pipeline 2007 Allografts (human origin)
• Pipeline 2010 Biologics (peptides)
• Challenges Increased need for synthetic
  materials due to legislative changes by the EU
  Bone Bank-Legislature (closure of approx. 80 
  of all bone banks)

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Infection therapy / tissue regeneration

• Indication Local antibiotic therapy in bone
  infections and infection of soft tissue adjacent
  to bone
• Pipeline
• Collagen matrices
• Membranes
• Hemostyptics
• Adhesive barriers
• Leading OEM manufacturer
• Complete portfolio of synthetic materials with
  added value
• Relevant partial market Europe approx. 50 million
  , market leaders Biomet  Resorba
• Challenges increasing resistance, new areas of
  application, paradigm change form human to
  synthetic materials

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Cerabone

• Hydroxyapatite ceramic
• Structure and porosity identical to human bone
• Osteoconductive
• After osteointegration, mechanical stability
  comparable to human bone
• Cerabone blocks in three sizes
• Cerabone granule in three different
  granulometries
• Radiologically positive

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Ostim

• Paste bone substitute material that is
  completely absorbed or replaced by bone
• Nanocrystals equivalent in size to the HA
  crystals in human bone
• Stimulation of osteoneogenesis
• Ostim35 35 HA in water

Status 5 months post-op
Status pre-op
Status immediately post-op
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PerOssal

• Synthetic bone replacement material with HA
  (Ostim) and calcium sulfate (pellets)
• Completely absorbable
• The Ostim component stimulates osteoneogenesis
• Permits uptake of fluids (e.g. antibiotic
  solutions)
• In concomitant administration of antibiotics,
  inclusion in contaminated bone defects is
  possible
• Makes antibiogram-compatible local antibiosis

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Contact address
aap Implantate AG Lorenzweg 5 12099
Berlin www.aap.de Customer Service Annett
Backert Tel. [phone] Fax [phone]
19 222 E-Mail a.backert_at_aap.de