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Carcinoma Stomach Carcinoma Colon Pleomorphic Adenoma

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Gastric fundal mucosa, with short pits lined by pale columnar mucus cells. Acute gastric ulcer ... Helicobacter pylori small curved to spiral rod-shaped ... – PowerPoint PPT presentation

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Title: Carcinoma Stomach Carcinoma Colon Pleomorphic Adenoma


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Carcinoma StomachCarcinoma ColonPleomorphic
Adenoma
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  • Stomach Cardia
  • Fundus
  • Body
  • Antrum
  • Pylorus
  • Cells Mucous secreting cells
  • Parietal cells or Oxyntic cells
  • Chief cells or Peptic cells
  • Endocrine cells-G cells

3
NORMAL STOMACH
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Gastric fundal mucosa, with short pits lined by
pale columnar mucus cells
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Acute gastric ulcer
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shallow gastric ulcerations known as "stress
ulcers"
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Complications of gastric ulcers (either benign or
malignant) include pain, bleeding, perforation,
and obstruction.
8
GASTRIC ULCER
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Helicobacter pylori small curved to spiral
rod-shaped bacterium methylene blue stain
10
Tumors of stomach
  • Benign tumors Adenomas, Polyps
  • Gastric Carcinoma
  • - Epithelial
  • - Non Epithelial
  • - Lymphoma

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Epithelial Malignant Tumors
  • Adeno carcinoma
  • -papillary
  • -Tubular
  • -Mucinous
  • -Signet ring cell type
  • -Undifferentiated
  • -Adenosquamous
  • -Small cell carcinoma
  • -Carcinoid Tumors

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Etiological factors
  • H. pylori
  • Smoked diet
  • Low socioeconomic status
  • Cigarette smoking
  • Chr. Gastritis
  • Barretts esophagitis
  • Blood group A
  • Family history, HNPCC syndrome

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Gross
  • Location
  • CLASSIFICATION
  • Depth of Invasion
  • Macroscopic pattern
  • Histologic subtype

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Classification
  • Early gastric ca
  • Advanced Gastric Ca
  • Exophytic growth
  • Flat growth
  • Excavated growth
  • Linitis plastica type
  • Intestinal type
  • Diffuse type

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Gastric adenocarcinoma.
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Stomach, early carcinoma - Gross, mucosal surface
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Stomach, advanced carcinoma - Gross, mucosal
surface
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linitis plastica stomach into a shrunken "leather
bottle" appearance.
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Gastric adenocarcinoma has infiltrated through
the wall and appears on the surface as irregular
tan masses.
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moderately differentiated gastric adenocarcinoma
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Signet ring cell adenocarcinoma
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signet ring cell pattern of adenocarcinoma
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NORMAL COLON
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POLYPS of COLON
  • Non Neoplastic Polyps
  • -Hyperplastic polyps
  • -Hamartomatous polyps
  • -Inflammatory polyps
  • -Lymphoid polyps

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Neoplastic Polyps
  • Adenomas
  • -Villous
  • -Tubular
  • -Tubulo villous adenomas
  • Adeno carcinomas

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Adenomatous polyp
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Adenomatous polyp
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Multiple adenomatous polyps of the cecum
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Familial polyposis coli.
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Familial polyposis coli.
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Adenocarcinoma of the colon
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Pleomorphic adenoma of parotid gland
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Normal salivary gland (submandibular)
53
Salivary gland, pleomorphic adenoma - Very low
power
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Pleomorphic adenoma (mixed tumor) of salivary
gland
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Pleomorphic adenoma of parotid gland
Mixed proliferation of both ductal epithelium and
a chondroid/myxomatous stroma
56
Epithelial elements dispersed within a background
of loose myxoid tissue containing islands of
fibrocartilage
57
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