Biophysics 101

1
Biophysics 101

• 22 February 2007

2
ApoE assignment

• Merging input files Mike
• Downloading multiple sequences Christopher
• Nucleotide level mutations Katie, Resmi, Xiaodi
• Mutations in introns or extrons - Zachary
• Protein level mutations Katie, Resmi, Tiffany,
  Xiaodi
• Selective pressures on synonymous codon frequency
  - Kay

3
Final project ideas

• Application
• Alzheimers desease
• Identify causal relationships gene?desease
  genome level
• Bioenergy cellulosic fuel
• Agroplanning and modelling
• Genotype Expressiontype
• Genotype ? RISK OMIM
• Desease outbreak BIOMAP
• Personal diagnosis - webMD
• Input
• 1 gene (ApoE)
• Particular desease genomes
• Random genomes or exonic sequences

• Characterization
• Identify variation (Coding and Non Coding)
• Codon usage
• Analysis
• Evolutionary processes (Codon bias selective
  pressure)
• Well known desease associations
• Action
• Medical / dietary action
• Directing research efforts

4
OMIM

• Online Mendelian Inheritance in Man
  http//www.ncbi.nlm.nih.gov/entrez/query.fcgi?dbO
  MIM
• OMIN Stats http//www.ncbi.nlm.nih.gov/Omim/mimsta
  ts.html