Protein Folding

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Protein Folding

• By Manisha Shrestha

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Protein Folding

• Introduction
• - What is a protein?
• - Diverse Function

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What is a Protein?

• Biomolecule composed of one or more polypeptide
  chains containing amino acid residues linked
  together via peptide bonds.

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Proteins Have Diverse Function

• Some functions
• Transport
• Storage
• Catalytic
• Structural
• Active component of immunity

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Protein Folding

• A protein must fold properly to attain its
  three-dimensional structure.
• Properly folded protein can sustain its function.
  

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Forces Stabilizing Protein Structure

• Covalent Bonds
• - Disulfide
• Noncovalent interactions
• - Hydrophobic Effect
• - Ionic
• - Hydrogen Bonding
• - Van der Waals

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Protein Folding

• http//www.cs.ucl.ac.uk/staff/D.Jones/t42morph.htm
  l

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Haemoglobin
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My Research

• Studying the expression and refolding of human
  beta defensin-3.

• Human Beta Defensin-3
• Found in human.
• Antimicrobial activity.

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Resources

• Three dimensional structure of proteins accessed
  from http//www.rcsb.org/pdb/home/home.do