Normal Ageing Vs Parkinson's Ageing

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(No Transcript)
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What is Parkinsons?

• Chronic and degenerative brain disorder
• Impairs muscle control, balance, and movement
• Causes the cells in substantia nigra (in the
  basal ganglia) to deteriorate
• Inhibits the brains ability to produce dopamine
  (the happy hormone)
• Although anyone is at the risk of getting PD, age
  is still the largest risk factor.

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Main symptoms of Parkinsons

• Tremor uncontrollable and unintended shaking
  that affects a body part
• Dystonia or stiffness muscles contract and
  become tighter and shorter than normal
• Bradykinesia or slowed movement caused by loss
  of muscle control, muscle weakness and
  deterioration

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Other symptoms

• Reduced blinking
• Drooling
• Hypomimia or masked face
• Dysphagia
• Micrographia or small handwriting
• Hypophonia or unusually soft voice
• Dyskinesia or involuntary movement such as
  jerks, twitches, and twisting movements that are
  uncontrollable
• Dizzy spells (attributed to levodopa-based
  treatments)
• Stooped posture
• Shuffling of feet, stopping short or inability to
  take steps ahead (freezing), and quickened pace
  with short steps.
• Difficulty in standing up after sitting for a
  long duration and vice versa

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Age-related progression

• Age plays an important role in the clinical
  progression of Parkinsons.
• As the patient grows older, they may experience
  -- Decline in motor function- Dementia-
  Cognitive impairment- Lowered responsiveness to
  levodopa

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Age-wise and stage-wise progression of
Parkinsons vs normal ageing


















Middle to Later stages of PD Mild PD symptoms Old age
Tremor Present even in rest Absent in 90 of patients Absent
Stiffness Typical cogwheel and lead pipe rigidity Variable Musculoskeletal stiffness
Slowness Typical with fatigue Variable General age-related slowness
Gait and balance disturbance Appears in later stages Appears at early onset Age-related axial impairment
Symmetry Asymmetrical Symmetrical Symmetrical
Dementia risk Increased Slightly increased Age related memory problems
Levodopa response Good Poor None
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Growing old is inevitable!

• And in the case of Parkinsons, growing old
  results in impairment of dopamine production.
• As the somatic nervous system begins to decline
  in function (due to age) the degeneration of
  cellular function, balance, coordination, and
  other motor symptoms progresses rapidly.

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Plexus Parkinsons Disease Rehabilitation Program

• At Plexus Neuro and Stem Cell Research Center, we
  use only autologous mesenchymal stem cells taken
  from the patients own body. As Indias leading
  stem cell specialists, we assure you of a safe
  treatment with absolutely no adverse effects.
• Stem cell therapy for Parkinsons involves - Stem
  cells are injected directly into the basal
  ganglia
• These cells have the potential to develop into
  dopamine-secreting neurons
• This slows down the progression of Parkinsons
• To know more about Parkinsons Regenerative
  Rehabilitation Program, call us on91 89048
  42087 080-2546 0886080-2547 0886 080-2549
  0886