What is B cell sorting?

1
What is B cell sorting?
single B cell analysis technology to enable the
development of potential optimized antibody
candidates.
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2
What are B cell diseases?
About 80 distinct autoimmune diseases have been
described, such as multiple sclerosis (MS) ,
rheumatoid arthritis (RA) and systemic lupus
erythematosus (SLE).
3
How is B cell deficiency treated?
Intravenous immunoglobulin (IVIG) replacement
therapy is the treatment of choice for most
primary B-cell disorders with hypogammaglobulinemi
a.
4
How do you test for B cell deficiency?
The standard screening tests for antibody
deficiency starts with measurement of
immunoglobulin levels in the blood serum.
5
What are 3 genetic defects that could lead to B
cell deficiency
defects of genes that encode the B cell receptor,
the µ chain, Ig alpha chain (CD79a), Ig beta
chain (CD79b) and the surrogate light chain lead
to loss of single B cell sorting.
6
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