Bispecific Antibody by Creative Biolabs

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Bispecific Antibody by Creative Biolabs
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Professionals never cease their interests in
studying bi-specific antibody. How much of you
know about bispecific antibodies? These are
bioengineered antibodies that contain two
different binding sites within a single molecule,
which can specifically bind two different types
of antigen.   The most widely used application
of bi-specific antibody is in cancer
immunotherapy, which creates a therapeutic
treatment approach for diseases with specific
medical needs.
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Compared with traditional antibodies, bispecific
antibodies have many advantages. The two arms can
bring an antigen-expressing cell in close
proximity to a killing cell and thus destroy the
tumor cell the two binding sites can
significantly increase affinity or
internalization rates of particular antigens on a
cell's surface by binding to two different
epitopes on an antigen they usually have a
higher cytotoxic potential to bind to antigens
with low expression level. Binding tumor cells
using a bi-specific antibody-drug conjugate (ADC)
also holds great promise for the future
development of therapeutics for a variety of
diseases.
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With the development of antibody engineering,
many types of bispecific antibodies have been
designed to enable short half-life,
immunogenicity and side-effects caused by
cytokine liberation. They include tri-functional
antibodies, chemically linked Fabs, and various
types of bivalent and trivalent single-chain
variable fragments (scFvs), fusion proteins
mimicking the variable domains of two antibodies.
The furthest developed of these newer formats are
the bi-specific T-cell engagers (BiTEs) and
mAb2's, antibodies engineered to contain an Fcab
antigen-binding fragment instead of the Fc
constant region.   
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• As a leader in the field of antibody engineering,
  Creative Biolabs has developed CeativeAbTM
  antibodies in order to increase the efficacy of
  current therapeutic antibodies.
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• Various Types of bispecific antibodies Creative
  Biolabs offers
• Tri-functional antibodies and chemically linked
  Fabs
• Bivalent,and Bispecific scFvs (tandem scFv,
  diabodies)
• Bi-specific T-cell engagers (BiTEs) 
• scFv-Fab Fusion Proteins

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Based on various antibody formats such as IgGs,
Fabs and scFvs, Creative Discovery PlatformTM of
Creative Biolabs provides a series of bispecific
antibodies to satisfy various needs from its
customers. It provides construction, including
expression and purification as well as
recombinant antibody production at scales,
ranging from hundreds of micrograms to grams
level.    By visiting Creative Biolabs, you can
learn more about bispecific antibody.
Copyright of www.creative-biolabs.com. For more
information contact us info_at_creative-biolabs.com