Antibody conjugation service

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One-stop ADC Development Service
www.creative-biolabs.com/adc
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Introduction
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Three major components define an ADCthe
monoclonal antibody, a cytotoxic payload, and a
molecular linker that covalently bridges the
other two components. A successful ADC should be
chemically and physiologically stable in blood
stream, exert similar antigen binding pattern
compared with the unconjugated antibody, and
exhibit desired payload toxicological effects
once internalized.
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ADC mode of action. ADC molecules travel to the
tumor site via systematic circulation, bind to
tumor surface antigens, and enter the tumor cells
via receptor mediated endocytosis
(internalization). The payload is released in the
cytosol or lysosome to eliminate the cancer cell
by disrupting important cellular pathways
(microtubule assembly, DNA transcription, mRNA
processing).
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Antibody Conjugation Service
A flow chart summarizing the design of an ADC.
Correlations between different components in an
ADC intertwine, making the ADC design a
challenging yet interesting process.
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ADC manufacturing process
Antibody screening services including the
consultation in antigen selection,
antigen-specific antibody screening,
internalizing antibody selection, as well as
proof-of-concept feasibility validation using
"Anti-Ab ADCs".
After ADC assembly, its biochemical
characteristics (purity, stability,
drug-to-antibody ratio) and in vitro efficacy is
adequately analyzed in ADC in vitro Analysis
while the ADC's pre-clinical pharmacological
parameters will be assayed in ADC in vivo
Analysis before clinical evaluation and
applications.
A suitable payload drug will be selected and
coupled with a linker with desired releasing
mechanism in DrugLnk to assemble the chemical
warhead for an ADC, which is subsequently
conjugated with the desired antibody using
Antibody Design and Conjugation services.
The conjugation of various molecular probes to
antibodies to form Antibody-based Probes and we
offer this service to facilitate the requirements
for the exponentially developing fields such as
high-resolution imagery and fast, accurate
diagnostics.
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Thanks
Reference https//www.creative-biolabs.com/adc/an
tibody-drug-conjugate-adc.htm