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Master Track BIOMedical Imaging and Modeling

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Methods and techniques from mathematics, computer science, physics, ... Polyp detection. in the colon (& AZM) Computer-Aided Diagnosis. Auditory fMRI. Auditory ... – PowerPoint PPT presentation

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Title: Master Track BIOMedical Imaging and Modeling


1
Master TrackBIOMedical Imagingand Modeling
  • Masters voorlichting
  • 27 januari 2004

2
Kiezen van afstudeeropdracht
  • Leuk en ..
  • Vaardigheidsblokken
  • Koppeling onderwijs-onderzoek
  • EHV LABORATORIUMBEZOEK 4 februari
  • Programma op (individuele maat) 5 van de 8
    vakken in divisie, diepgang
  • Begin bij de contactpersoon
  • Hoe kom je aan de contactpersoon?

3
  • Methods and techniques from mathematics,
    computer science, physics, electrical engineering
    and medicine are used in the imaging, modelling
    and interpretation of biomedical systems.
  • Numerous collaborations with more
  • applicationally oriented groups.

4
  • 2 secties
  • Sectie 1 Image analysis and interpretation
  • Bart ter Haar Romeny
  • Image Analysis
  • Bart ter Haar Romeny
  • Image Processing in Clinical Applications
  • Frans Gerritsen

5
  • 2 secties
  • Sectie 2 Biomodeling Peter Hilbers
  • Biosignals and regulation
  • Paul van de Bosch, Guid Oeij, Ton
    Wagenmakers
  • Neurophysics
  • Herman Kingma
  • - Biomodeling and Bioinformatics
  • Peter Hilbers

6
  • MAAR veel samenwerking over de grenzen van de
    divisie
  • Voorbeelden
  • Vital Imaging Dick Slaaf
  • Spiermetabolisme Klaas Nicolay
  • - Modelling of biochemical molecules Bert
    Meijer

7
Biomedical Image Analysis (ter Haar Romeny)
  • Answering questions on images,
  • and showing the answers

www.bmi2.bmt.tue.nl/image-analysis
  • Research areas
  • Multi-Scale Image processing
  • Functions Library
  • Image Processing in Clinical
  • Applications

8
Multi-Scale Image Processing
  • Mathematical models based on the working of our
    human visual system
  • Image enhancement
  • Image segmentation
  • Motion detection
  • Texture analysis

Functions Library in Mathematica
9
Image Processing in Clinical Applications (Frans
Gerristen)
  • Segmentation and Analysis

10
Image Processing in Clinical Applications (Frans
Gerristen)
  • Visualization

11
Image Processing in Clinical Applications(Frans
Gerristen)
  • Therapy Simulation
  • Computer Aided Diagnosis

Courtesy of Stanford University
12
Computer-Aided Diagnosis
  • CT Thorax lung noduledetection
  • Polyp detectionin the colon ( AZM)

13
Auditory fMRI
Auditory cortex
Sound characteristics
14
Neurophysics(Kingma)
  • Physics of the senses, 4 Research topics
  • Vestibular sense motion, balance control
  • Auditive sense mechanisms of hearing
  • Ophtalmology cornea
  • Neurophysiology epileptics

15
BioSignals and Regulation - BIOMIM
cardiac
bioregulation
bioregulation
physiology
Biosignals

Biosignals

Regulation
Regulation
biosignals
biosignals
skeletal muscle
physiology
signals and systems
signals and systems
physiology
physiology
16
Biosignals
  • Jan Bergmans
  • Hans Blom
  • Pierre Cluitmans
  • Erik Korsten
  • Guid Oei

17
Fetal ECG monitoring
18
Bioregulation
  • Quantitative physiology
  • System biology from an integral perspective
  • Understanding regulatory mechanisms
  • Influence bioregulation

opening the black box
19
Bioregulation
  • Paul van den Bosch
  • Kenneth Meijer
  • Natal van Riel
  • Hans Savelberg
  • Ger van der Vusse
  • Ton Wagenmakers

20
System identification and parameter estimation to
analyse changed calcium handling in diseased,
intact heart
  • High frequency sampling (200 Hz) of
  • Free calcium (using fluorescent dye)
  • Left ventricular pressure

Model of calcium transients.
21
Spatio-temporal models to understand
physiological mechanisms of uptake and transport
of Fatty Acids in myocardium
  • Components
  • Phospholipids
  • Cholesterol
  • Proteins
  • Glycocalyx

22
New experimental model to quantify insulin
sensitivity of muscle and liver in type 2 diabetes
Supported by Diabetes Fonds Nederland
Traditional methods either cannot generate the
sought answers or are invasive
Main determinants of high blood glucose
23
Functional effects of muscle adaptation a
simulation in AnyBody
  • Adaptive muscle models
  • Multi-body modeling
  • Simulation of therapeutic interventions and
    training protocols

24
Biomodelling and Informatics(Hilbers) 6 research
topics
Neural networks, gene expression and
clusteringsalgoritmes
Heart simulations
Cell, metabolic pathways
Bone simulations
Biomembranes
Genetic algorithms
25
Lipids
  • Biomembrane consists mainly of (phospho)lipids

stearic acid
dipalmitoylphosphatidylcholine (DPPC)
1-stearoyl-2-oleoylphosphatidylcholine (SOPC)
apolar hydrophobic
polar hydrophilic
26
Vesicle formation
27
Vital Imaging (Slaaf, van Zandvoort)
  • Location Vital Imaging Unit CARIM / BME,
  • dept of Biophysics,Maastricht
  • Vital imaging applied to vascular and cellular
    research atherosclerosis
  • EquipmentTwo-photon excitation (Lifetime)
    Scanning Microscopy
  • Intercellular communication of blood cells and
    vessel wall in vivo synchronization of images
    with heart rate.
  • (De) differentiation and apoptosis in the
    cardiovascular system
  • Tissue characterization (3D) of plaques in vivo
  • Technical developments

28
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