Title: Master Track BIOMedical Imaging and Modeling
1Master TrackBIOMedical Imagingand Modeling
- Masters voorlichting
- 27 januari 2004
2Kiezen van afstudeeropdracht
- Leuk en ..
- Vaardigheidsblokken
- Koppeling onderwijs-onderzoek
- EHV LABORATORIUMBEZOEK 4 februari
- Programma op (individuele maat) 5 van de 8
vakken in divisie, diepgang - Begin bij de contactpersoon
- Hoe kom je aan de contactpersoon?
3- Methods and techniques from mathematics,
computer science, physics, electrical engineering
and medicine are used in the imaging, modelling
and interpretation of biomedical systems. - Numerous collaborations with more
- applicationally oriented groups.
4- 2 secties
- Sectie 1 Image analysis and interpretation
- Bart ter Haar Romeny
- Image Analysis
- Bart ter Haar Romeny
- Image Processing in Clinical Applications
- Frans Gerritsen
5- 2 secties
- Sectie 2 Biomodeling Peter Hilbers
-
- Biosignals and regulation
- Paul van de Bosch, Guid Oeij, Ton
Wagenmakers - Neurophysics
- Herman Kingma
- - Biomodeling and Bioinformatics
- Peter Hilbers
6- MAAR veel samenwerking over de grenzen van de
divisie - Voorbeelden
- Vital Imaging Dick Slaaf
- Spiermetabolisme Klaas Nicolay
- - Modelling of biochemical molecules Bert
Meijer
7Biomedical Image Analysis (ter Haar Romeny)
- Answering questions on images,
- and showing the answers
www.bmi2.bmt.tue.nl/image-analysis
- Research areas
- Multi-Scale Image processing
- Functions Library
- Image Processing in Clinical
- Applications
8Multi-Scale Image Processing
- Mathematical models based on the working of our
human visual system
- Image enhancement
- Image segmentation
- Motion detection
- Texture analysis
-
Functions Library in Mathematica
9Image Processing in Clinical Applications (Frans
Gerristen)
- Segmentation and Analysis
10Image Processing in Clinical Applications (Frans
Gerristen)
11Image Processing in Clinical Applications(Frans
Gerristen)
Courtesy of Stanford University
12Computer-Aided Diagnosis
- CT Thorax lung noduledetection
- Polyp detectionin the colon ( AZM)
13Auditory fMRI
Auditory cortex
Sound characteristics
14Neurophysics(Kingma)
- Physics of the senses, 4 Research topics
- Vestibular sense motion, balance control
- Auditive sense mechanisms of hearing
- Ophtalmology cornea
- Neurophysiology epileptics
15BioSignals and Regulation - BIOMIM
cardiac
bioregulation
bioregulation
physiology
Biosignals
Biosignals
Regulation
Regulation
biosignals
biosignals
skeletal muscle
physiology
signals and systems
signals and systems
physiology
physiology
16Biosignals
- Jan Bergmans
- Hans Blom
- Pierre Cluitmans
- Erik Korsten
- Guid Oei
17Fetal ECG monitoring
18Bioregulation
- Quantitative physiology
- System biology from an integral perspective
- Understanding regulatory mechanisms
- Influence bioregulation
opening the black box
19Bioregulation
- Paul van den Bosch
- Kenneth Meijer
- Natal van Riel
- Hans Savelberg
- Ger van der Vusse
- Ton Wagenmakers
20System identification and parameter estimation to
analyse changed calcium handling in diseased,
intact heart
- High frequency sampling (200 Hz) of
- Free calcium (using fluorescent dye)
- Left ventricular pressure
Model of calcium transients.
21Spatio-temporal models to understand
physiological mechanisms of uptake and transport
of Fatty Acids in myocardium
- Components
- Phospholipids
- Cholesterol
- Proteins
- Glycocalyx
22New experimental model to quantify insulin
sensitivity of muscle and liver in type 2 diabetes
Supported by Diabetes Fonds Nederland
Traditional methods either cannot generate the
sought answers or are invasive
Main determinants of high blood glucose
23Functional effects of muscle adaptation a
simulation in AnyBody
- Adaptive muscle models
- Multi-body modeling
- Simulation of therapeutic interventions and
training protocols
24Biomodelling and Informatics(Hilbers) 6 research
topics
Neural networks, gene expression and
clusteringsalgoritmes
Heart simulations
Cell, metabolic pathways
Bone simulations
Biomembranes
Genetic algorithms
25Lipids
- Biomembrane consists mainly of (phospho)lipids
stearic acid
dipalmitoylphosphatidylcholine (DPPC)
1-stearoyl-2-oleoylphosphatidylcholine (SOPC)
apolar hydrophobic
polar hydrophilic
26Vesicle formation
27Vital Imaging (Slaaf, van Zandvoort)
- Location Vital Imaging Unit CARIM / BME,
- dept of Biophysics,Maastricht
- Vital imaging applied to vascular and cellular
research atherosclerosis - EquipmentTwo-photon excitation (Lifetime)
Scanning Microscopy - Intercellular communication of blood cells and
vessel wall in vivo synchronization of images
with heart rate. - (De) differentiation and apoptosis in the
cardiovascular system - Tissue characterization (3D) of plaques in vivo
- Technical developments
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